Lisa C. Heather

Department of Physiology, University of Oxford

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Cardiovascular research\| PubMed ID: 17034771	2006
In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18689683	2008
Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19329759	2009
Critical role of complex III in the early metabolic changes following myocardial infarction. Cardiovascular research\| PubMed ID: 19666902	2010
Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society\| PubMed ID: 19826179	2009
Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart. Endocrinology\| PubMed ID: 19940039	2010
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Human molecular genetics\| PubMed ID: 20660115	2010
Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS. NMR in biomedicine\| PubMed ID: 20799252	2011
Metabolism, hypoxia and the diabetic heart. Journal of molecular and cellular cardiology\| PubMed ID: 21262230	2011
A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart. Basic research in cardiology\| PubMed ID: 21318295	2011
Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate. NMR in biomedicine\| PubMed ID: 21387444	2011
Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis. PloS one\| PubMed ID: 22028857	2011
Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic research in cardiology\| PubMed ID: 22538979	2012
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Cardiovascular research\| PubMed ID: 22593200	2012
A practical guide to metabolomic profiling as a discovery tool for human heart disease. Journal of molecular and cellular cardiology\| PubMed ID: 23231771	2012
Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion. Circulation. Heart failure\| PubMed ID: 23940308	2013
Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin. Cardiovascular diabetology\| PubMed ID: 24063408	2013
Investigating mitochondrial metabolism in contracting HL-1 cardiomyocytes following hypoxia and pharmacological HIF activation identifies HIF-dependent and independent mechanisms of regulati... Journal of cardiovascular pharmacology and therapeutics\| PubMed ID: 24607765	2014
Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. The Journal of physiology\| PubMed ID: 25172947	2014
Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. Circulation. Cardiovascular imaging\| PubMed ID: 25201905	2014
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. Cell transplantation\| PubMed ID: 25751158	2016
Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study. Diabetes\| PubMed ID: 25795215	2015
Increased oxidative metabolism following hypoxia in the type 2 diabetic heart, despite normal hypoxia signalling and metabolic adaptation. The Journal of physiology\| PubMed ID: 26574233	2016
Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization. Biochimica et biophysica acta\| PubMed ID: 27090938	2016
On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27103577	2016
The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27422990	2016
Assessment of Metformin-Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate. Diabetes\| PubMed ID: 27561726	2016
Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS. NMR in biomedicine\| PubMed ID: 27779334	2016
An essential cell-autonomous role for hepcidin in cardiac iron homeostasis. eLife\| PubMed ID: 27897970	2016
Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation. Cardiovascular research\| PubMed ID: 28419197	2017
The 'Goldilocks zone' of fatty acid metabolism; to ensure that the relationship with cardiac function is just right. Clinical science (London, England : 1979)\| PubMed ID: 28739841	2017
Bernard and Joan Marshall Awards at the autumn meeting of the British Society for Cardiovascular Research 2017. Heart (British Cardiac Society)\| PubMed ID: 29925542	2018
Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes. JACC. Basic to translational science\| PubMed ID: 30175272	2018
Hypoxia-inducible factor 1 signalling, metabolism and its therapeutic potential in cardiovascular disease. Biochimica et biophysica acta. Molecular basis of disease\| PubMed ID: 30266651	2019
The long non-coding RNA is a post transcriptional regulator of mitochondrial complex I catalytic activity. eLife\| PubMed ID: 31045494	2019
Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized C magnetic resonance spectroscopy. NMR in biomedicine\| PubMed ID: 31090979	2019
Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus. Diabetologia\| PubMed ID: 32728894	2020
Positioning Metabolism as a Central Player in the Diabetic Heart. Journal of lipid and atherosclerosis\| PubMed ID: 32821724	2020
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol. JCI insight\| PubMed ID: 32879143	2020
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI. Communications biology\| PubMed ID: 33214680	2020
Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in t... NMR in biomedicine\| PubMed ID: 33458907	2021
Rapid, -insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux. Magnetic resonance in medicine\| PubMed ID: 33538063	2021
Peritransplant Cardiometabolic and Mitochondrial Function: The Missing Piece in Donor Heart Dysfunction and Graft Failure. Transplantation\| PubMed ID: 33617201	2021
L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI. Metabolites\| PubMed ID: 33806953	2021
Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes. Scientific reports\| PubMed ID: 33833285	2021
Activation of HIF1α Rescues the Hypoxic Response and Reverses Metabolic Dysfunction in the Diabetic Heart. Diabetes\| PubMed ID: 34526367	2021
Acute intermittent hypoxia drives hepatic lipogenesis in humans and rodents. Metabolism open\| PubMed ID: 35313531	2022
Guidelines on models of diabetic heart disease. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 35657616	2022
Post-translational palmitoylation of metabolic proteins. Frontiers in physiology\| PubMed ID: 36909239	2023
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury. Experimental physiology\| PubMed ID: 37184360	2023
Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities. British journal of cancer\| PubMed ID: 37563220	2023
CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease. Physiological reviews\| PubMed ID: 37882731	2024
Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology. Diabetes\| PubMed ID: 38387045	2024
AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats. Journal of molecular and cellular cardiology\| PubMed ID: 38643934	2024
Targeting glucose metabolism with dichloroacetate (DCA) reduces zika virus replication in brain cortical progenitors at different stages of maturation. Antiviral research\| PubMed ID: 38851593	2024
Cardiometabolic risk factors vary with age differently in females and males. Nature cardiovascular research\| PubMed ID: 39196078	2022
FoxO1-zDHHC4-CD36 S-Acylation Axis Drives Metabolic Dysfunction in Diabetes. Circulation research\| PubMed ID: 40357580	2025
Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets. Nature reviews. Cardiology\| PubMed ID: 40544173	2025
Systems Biology and Functional Assessments of Human iPSC-Cardiomyocyte Models of Insulin Resistance Capture Key Hallmarks of Diabetic Cardiomyopathy. Diabetes\| PubMed ID: 40956683	2025
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration. Nature cardiovascular research\| PubMed ID: 41034455	2025
The metabolic balancing act between fatty acid and glucose substrate use for optimal myocardial function: key role for membrane substrate transporters. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 41784153	2026
Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart. Cellular and molecular life sciences : CMLS\| PubMed ID: 41886090	2026