mapping-knowledge-landscape-muscle-disorders-rheumatoid-arthritis

Mapping the Knowledge Landscape of Muscle Disorders in Rheumatoid Arthritis: A Bibliometric and Bioinformatics Study

This study conducted a bibliometric analysis of publications related to the comorbidity between rheumatoid arthritis (RA) and Muscle Disorders, sourced ...

China-Japan friendship hospital

Kudiezi (KDZ) injection is commonly used in traditional Chinese medicine as treatment for cerebral infarction and angina pectoris. The present study investigated the therapeutic effects of KDZ injection on myocardial injury induced by acute cerebral ischemia and the possibly protective mechanisms.

Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats.

Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to observe the effect of Chinese medicine Wentong decoction (WTD) in EOS apoptosis in asthmatic rats. This work also explored the mechanism of WTD regulation in EOS apoptosis and provided a new target for clinical treatment of asthma.

Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS.

 Immune checkpoint inhibitors (ICIs) have previously been reported to have a promising potential in terms of the improvement of outcomes in non-small cell lung cancer (NSCLC). Fatal adverse events (FAEs) of ICIs are relatively uncommon, and the incidence and risk in NSCLC remain unclear. In the present study, we conducted a systematic review and meta-analysis to evaluate the risk of FAEs in NSCLC patients administered with ICIs.  Potentially relevant studies were identified in PubMed, EMBASE, and Cochrane library database from inception to September 16, 2020. The systematic review and meta-analysis included randomized controlled trials that reported treatment-related FAEs in NSCLC. The pooled incidence and risk ratios (RRs) were calculated to evaluate prospective risk.  Twenty clinical trials that included a total of 13,483 patients were selected for the meta-analysis. The overall incidence of FAEs was 0.65% [95% confidence interval (CI) = 0.31-1.07,   = 50.2%] in ICI monotherapy, 1.17% (95% CI = 0.74-1.69,   = 56.3%) in chemotherapy, and 2.01% (95% CI = 1.42-2.69,   = 5.9%) in the combination therapy (ICI and chemotherapy). ICI monotherapy was associated with lower incidence of FAEs caused by blood system disorders (RR = 0.23, 95% CI = 0.07-0.73,  = 0.013,   = 0%) and infectious diseases (RR = 0.29, 95% CI = 0.13-0.63,  = 0.002,   = 0%). The incidence of pneumonitis significantly increased in immunotherapy (RR = 5.72, 95% CI = 1.14-28.80,  = 0.03,   = 0%).  The results of the present study demonstrate that ICI monotherapy decreases the risk of FAEs, whereas the combined regimens with chemotherapy have the opposite tendency as compared to conventional chemotherapy. While the patients who received chemotherapy suffered the risks of death mainly from myelosuppression and infection, those who received immunotherapy were mainly threatened by immune-related pneumonitis.

Fatal Adverse Events Associated With Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

 To investigate the impact of different baseline characteristics on the efficacy of immune checkpoint inhibitors (ICIs) for advanced lung cancer.  In order to identify eligible randomized controlled trials (RCTs), a systematic search was conducted in PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases. The primary outcomes were hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS). To explore the potential interaction during the administration of ICI, patients were stratified by baseline characteristics.  The meta-analysis included 24 RCTs. ① Compared with non-ICI therapy, patients with lung cancer benefitted more from immunotherapy (HR, 0.78;  < 0.0001). ② Patients without liver metastases could get more survival benefits than those with liver metastases (HR, 1.20;  = 0.0139). Similar outcomes were also observed in the following subgroups: small-cell lung cancer (HR, 1.20;  = 0.0433), subsequent line (HR, 1.40;  = 0.0147), and ICI monotherapy (HR, 1.40;  = 0.0147). ③ Subgroup analysis showed that tumor type affected the efficacy of immunotherapy in patients with brain metastases (HR, 0.72 vs. 1.41; interaction,  < 0.01). Among patients with smoking history (HR, 0.87 vs. 1.23; interaction,  = 0.05) and brain metastases (HR, 0.69 vs. 1.21; interaction,  = 0.05), the type of therapy (i.e., monotherapy or combination therapy) had potential influences on the efficacy of immunotherapy.  Some critical baseline characteristics could indicate the efficacy of ICI therapy. Liver metastasis status could predict the efficacy of ICI therapy for lung cancer. Compared with small-cell lung cancer, patients with brain metastases might have durable OS in non-small-cell lung cancer. The smoking history or brain metastasis status of patients could indicate the potential clinical benefits of monotherapy or combination therapy.

The influence of baseline characteristics on the efficacy of immune checkpoint inhibitors for advanced lung cancer: A systematic review and meta-analysis.

Balloon pulmonary angioplasty (BPA) is an effective intervention for patients with chronic thromboembolic pulmonary disease (CTEPD). We aimed to identify the patient group with a low success rate or high complication rate of BPA, which is still unclear.

Article	Year
Kudiezi injection mitigates myocardial injury induced by acute cerebral ischemia in rats. BMC complementary and alternative medicine\| PubMed ID: 28056927	2017
Wentong decoction cures allergic bronchial asthma by regulating the apoptosis imbalance of EOS. Chinese medicine\| PubMed ID: 29713367	2018
Fatal Adverse Events Associated With Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis. Frontiers in medicine\| PubMed ID: 33659263	2021
The influence of baseline characteristics on the efficacy of immune checkpoint inhibitors for advanced lung cancer: A systematic review and meta-analysis. Frontiers in pharmacology\| PubMed ID: 36176428	2022
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Disease: Success Rate and Complications among Different Patient Populations. Respiration; international review of thoracic diseases\| PubMed ID: 39137746	2025

Ting Yao

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