enhancement-intestinal-recombinant-adeno-associated-virus-absorption

Enhancement of Intestinal Recombinant Adeno-Associated Virus Absorption by a Traditional Chinese Medicine Formula

Oral recombinant adeno-associated virus (rAAV) delivery holds significant therapeutic potential but is limited by inefficient intestinal absorption. ...

Fudan University

Phthalate esters (PAEs) are a group of endocrine disrupting compounds, which have been widely used as plasticizers. To alleviate the environmental and health threats from water resources polluted by PAEs, we prepared phenyl functionalized mesoporous silica materials (ph-SBA-15) were synthesized by a simple post-modification approach for rapid and efficient removal of low concentration of di-n-butyl phthalate (DBP) from aqueous solution. Mesostructure, texture, surface chemistry and surface charges were systemically characterized. The obtained ph-SBA-15 possesses a highly ordered mesostructure, a high surface area (418m/g), uniform mesopores (6.5nm) and high-density organic groups around 11wt.%. Batch adsorption experiments revealed that phenyl modified SBA-15 had an excellent ability to remove DBP with the maximum adsorption capacity up to ∼40mg/g at 25°C. The thermodynamics and kinetics for the adsorption were also investigated, demonstrating an exothermic, multi-layer and fast adsorption process. In addition, DBP adsorption was found to be sensitive to the pH and the uptake was observed to be greatest at around pH 7.0. Furthermore, this material can be effectively regenerated by ethanol.

Phenyl-functionalized mesoporous silica materials for the rapid and efficient removal of phthalate esters.

Malignant ascites (MA) is a common manifestation in advanced gastric cancer with peritoneal carcinomatosis and usually indicates a poor prognosis. However, lack of in vitro models that can faithfully recapitulate the characteristics of tumour cells in ascites hinders related researches. Tumour organoids have emerged as a robust in vitro model for tumour research and drug screening. Hence, we aimed to generate a 3-D in vitro organoid cultures from malignant ascites of gastric cancer for disease modelling and drug screening.

Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening.

Ferroptosis is a novel iron-dependent cell death, and an increasing number of studies have shown that long non-coding RNA (lncRNAs) are involved in the ferroptosis process. However, studies on ferroptosis-related lncRNAs in lung squamous cell carcinoma (LUSC) are limited. In addition, the prognostic role of ferroptosis-related lncRNAs and their relationship with the immune microenvironment and methylation of LUSC is unclear. This study aimed to investigate the potential prognostic value of ferroptosis-related lncRNAs and their involved biological functions in LUSC.

Article	Year
Phenyl-functionalized mesoporous silica materials for the rapid and efficient removal of phthalate esters. Journal of colloid and interface science\| PubMed ID: 27794236	2017
Malignant ascites-derived organoid (MADO) cultures for gastric cancer in vitro modelling and drug screening. Journal of cancer research and clinical oncology\| PubMed ID: 31598791	2019
Systematic analysis of ferroptosis-related long non-coding RNA predicting prognosis in patients with lung squamous cell carcinoma. Translational lung cancer research\| PubMed ID: 35529787	2022

Huawei Xu

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