enhancement-intestinal-recombinant-adeno-associated-virus-absorption

Enhancement of Intestinal Recombinant Adeno-Associated Virus Absorption by a Traditional Chinese Medicine Formula

Oral recombinant adeno-associated virus (rAAV) delivery holds significant therapeutic potential but is limited by inefficient intestinal absorption. ...

Naval Medical University

Ginsenoside Rh1 (G-Rh1) has been confirmed to inhibit the growth of breast cancer and colon cancer, but its therapeutic effect on hepatocellular carcinoma (HCC) is unclear. This study investigates the therapeutic effect of G-Rh1 on HCC as well as the underlying mechanism.

Ginsenoside Rh1 regulates the immune microenvironment of hepatocellular carcinoma via the glucocorticoid receptor.

Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited efficacy of current immunotherapeutic strategies. Immunogenic cell death (ICD), characterized by the release of damage-associated molecular patterns (DAMPs), offers a promising approach to enhance antitumor immunity. Arsenic trioxide (ATO), an ICD inducer, may synergize with PD-1 inhibitors to overcome therapeutic resistance, though the underlying mechanisms remain unclear.

Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway.

ChatGPT-4.0 and the ChatGLM series are novel conversational large language models (LLMs). ChatGLM includes 3 versions: ChatGLM4 (with internet connectivity but no knowledge base pretraining), ChatGLM4+Knowledge base (combining internet search capabilities with knowledge base pretraining), ChatGLM3-6B (offline knowledge base pretraining but no internet connectivity). The ability of ChatGPT-4.0 and ChatGLM to apply medical knowledge in the Chinese environment has been preliminarily verified, but the potential of the 2 models for clinical assistance in traditional Chinese medicine (TCM) is still unknown.

Performance Assessment of ChatGPT-4.0 and ChatGLM Series in Traditional Chinese Medicine for Metabolic Associated Fatty Liver Disease: Comparative Study.

Article	Year
Ginsenoside Rh1 regulates the immune microenvironment of hepatocellular carcinoma via the glucocorticoid receptor. Journal of integrative medicine\| PubMed ID: 39455405	2024
Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway. Immunity, inflammation and disease\| PubMed ID: 40504080	2025
Performance Assessment of ChatGPT-4.0 and ChatGLM Series in Traditional Chinese Medicine for Metabolic Associated Fatty Liver Disease: Comparative Study. JMIR formative research\| PubMed ID: 40854301	2025

Tianxiao Zheng

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