effects-ecological-momentary-interventions-on-glycated-hemoglobin

Effects of Ecological Momentary Interventions on Glycated Hemoglobin, Body Mass Index, and Quality of Life in People with Type 2 Diabetes: A Review

The global prevalence of type 2 diabetes mellitus (T2DM) continues to rise. Effective blood glucose and weight management are crucial for disease control ...

Chengdu University of Traditional Chinese Medicine

Based on life-course theory, adverse childhood experiences (ACEs) have emerged as risk factors for health in later life. This study aimed to explore the association between ACEs and frailty.

The Association between Adverse Childhood Experiences and Frailty: A Systematic Review.

[Not Available].

Music Therapy (MT) is reported to alleviate anxiety and depression in patients with lung cancer, but there is a lack of conclusive studies on the effects of MT. The purpose of this study is to explore the effects of MT on anxiety, depression, pain, sleep quality, and quality of life in lung cancer patients.

The effect of music therapy on anxiety, depression, pain and sleep quality of lung cancer patients: a systematic review and meta-analysis.

Depression is a serious and common complication of diabetes, with a well-established link between the two conditions. Recent studies indicate that activation of the NLRP3 inflammasome in hippocampal microglia plays a key role in the pathogenesis of diabetes complicated with depression (DD). While environmental enrichment (EE) has demonstrated significant anti-neuroinflammatory effects, its potential to alleviate neuroinflammation specifically induced by DD remains unclear. The DD rat model was established using a combination of a high-fat diet, streptozotocin injection, and chronic unpredictable mild stress. The effects of EE on NLRP3 inflammasome activation in the hippocampal microglia of DD rats were examined through a series of behavioral tests (open field test, forced swim test, and elevated plus maze), along with enzyme-linked immunosorbent assays, hematoxylin and eosin staining, TdT-mediated dUTP nick-end labeling staining, Western blot analysis, and immunofluorescence. Compared to the control group, DD rats exhibited impaired glucose metabolism and increased depressive-like behaviors, alongside hippocampal neuronal damage and elevated apoptosis rates. Activation of the NLRP3 inflammasome in hippocampal microglia was observed, with upregulation of the NLRP3 signaling pathway and inhibition of the PI3K/AKT signaling pathway. EE significantly mitigated these effects, reducing hippocampal neuroinflammation and alleviating depressive behaviors in DD rats. Neuroinflammation in the hippocampus is a key mechanism underlying the pathogenesis of DD. This study demonstrated that EE reduces neuroinflammation, likely by inhibiting the activation of the NLRP3 inflammasome in hippocampal microglia.

Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats.

To systematically evaluate the factors associated with multidimensional frailty assessed by the Tilburg Frailty Indicator among community-dwelling older adults.

Article	Year
The Association between Adverse Childhood Experiences and Frailty: A Systematic Review. Journal of the American Medical Directors Association\| PubMed ID: 38796164	2024
[Not Available]. Journal of the American Medical Directors Association\| PubMed ID: 39674572	2025
The effect of music therapy on anxiety, depression, pain and sleep quality of lung cancer patients: a systematic review and meta-analysis. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer\| PubMed ID: 39928168	2025
Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats. Scientific reports\| PubMed ID: 40269100	2025
Influencing factors for multi-dimensional frailty of older adults in community: A systematic review and meta-analysis. Archives of gerontology and geriatrics\| PubMed ID: 40516420	2025

Shuyang Ji

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