structured-exercise-regimen-pulmonary-hypertension-right-ventricular

Structured Exercise Regimen in Pulmonary Hypertension-Right Ventricular Failure in an Ovine Model

Right heart failure (RHF) is a significant cause of morbidity and mortality from pulmonary hypertension (PH). To better understand the pathophysiology and ...

Vanderbilt University Medical Center

Orthotopic liver transplantation has been rarely associated with myocardial calcification; no prior cases of asymptomatic calcification have been documented. We present the unique finding of asymptomatic myocardial calcification following orthotopic liver transplantation.

Extensive Myocardial Calcification Rapidly Progressing After Orthotopic Liver Transplantation.

Local surgeon recovery of donor livers and kidneys is common and well-studied. This practice is rare and poorly studied in cardiac transplantation. We examined clinical outcomes of cardiac allografts recovered by local surgeons vs. recipient institution surgeons.

Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons.

The lung composite allocation score (CAS) aims to improve waitlist outcomes for lung transplant candidates by prioritizing characteristics that reflect transplant urgency, including extracorporeal membrane oxygenation bridge to lung transplant (ECMO-BTT). Whether ECMO-BTT has been impacted by CAS is unknown. We analyzed the Organ Procurement and Transplant Network database to examine differences in ECMO-BTT utilization and characteristics and outcomes between transplant recipients who were transplanted one year before and one year after CAS implementation. Lung transplant recipients who received ECMO-BTT in the post-CAS era were younger ( < 0.01), more likely to be on ECMO at transplant listing rather than be initiated after ( < 0.05), and had shorter waitlist time ( < 0.01). Waitlist time was shorter in the post-CAS era among recipients (even non-ECMO) with high allocation scores only. This may have contributed to decreased use of ECMO-BTT in the post-CAS era ( = 0.03). One-year post-transplant survival did not differ between eras for ECMO-BTT patients, though was significantly better in the CAS era for non-ECMO-BTT patients (92% vs 90%,  < 0.01). We report initial results of ECMO-BTT utilization in the post-CAS era.

Extracorporeal membrane oxygenation bridge to transplant in the era of the lung composite allocation score.

Successful extracorporeal membrane oxygenation bridge to lung transplant with a patient transported from Hawaii to Nashville, Tennessee.

Comparison of Cellular and Acellular Perfusate in the Dynamic Organ Storage System Using a Porcine Donation After Circulatory Death Model.

Providing adequate, awake and ambulatory mechanical circulatory support to patients with rapidly progressive advanced intersitial lung disease (ILD) remains challenging. In a subset of ILD patients with refractory hypoxemia or hemodynamic instability, despite optimal veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) support, the addition of a veno-arterial (V-A) ECMO circuit may avoid the need for mechanical ventilation and protect against right ventricular dysfunction and subsequent end-organ dysfunction.

Rescuing lung transplant candidates with rapidly progressive interstitial lung disease who fail V-V ECMO: A case series of dual veno-arterial and veno-venous extracorporeal membrane oxygenation circuits.

Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic end stage lung disease. There are few long-term treatment options for end stage COPD due to donor lung scarcity. Durable artificial lung therapies may provide alternatives for long-term respiratory support. Veno-venous extracorporeal membrane oxygenation can provide physiologic support, but current cannulation configurations are suboptimal for durable support.

Determining an optimal central cannulation strategy for ambulatory veno-venous extracorporeal life support.

Extracorporeal membrane oxygenation as a bridge to lung transplant in the composite lung allocation score era: A single-center experience.

Donation after circulatory death (DCD) donors have expanded the heart transplant donor pool. Current DCD recovery strategies typically require donor heart reanimation but remain limited by logistical complexity, cost, and ethical concerns. These challenges are further amplified in heart-lung transplantation. Although brain-dead donors (DBD) have historically been the primary source of heart-lung blocs, successful DCD heart-lung transplantation has recently been reported. However, most cases rely on thoracoabdominal normothermic regional perfusion (TA-NRP), which has limited global adoption and raises concerns regarding ethical considerations and lung utilization. Rapid recovery with extended ultra-oxygenation preservation (REUP) has recently emerged as an alternative strategy for DCD heart recovery without pre-implant reanimation. In this report, we describe the first application of the REUP technique in concert with direct lung procurement to recover an en bloc heart-lung, enabling successful combined heart-lung transplantation with excellent early graft function.

Expanding the Donor Pool Further-Rapid Recovery Without Pre-implant Reanimation for Combined Heart-Lung Donation After Circulatory Death Transplantation.

Article	Year
Extensive Myocardial Calcification Rapidly Progressing After Orthotopic Liver Transplantation. JACC. Case reports\| PubMed ID: 39691877	2024
Save a trip: Clinical outcomes of cardiac allografts recovered by local surgeons compared to recipient center surgeons. JHLT open\| PubMed ID: 40144840	2025
Extracorporeal membrane oxygenation bridge to transplant in the era of the lung composite allocation score. JHLT open\| PubMed ID: 40475035	2025
Successful extracorporeal membrane oxygenation bridge to lung transplant with a patient transported from Hawaii to Nashville, Tennessee. JTCVS techniques\| PubMed ID: 40814650	2025
Comparison of Cellular and Acellular Perfusate in the Dynamic Organ Storage System Using a Porcine Donation After Circulatory Death Model. ASAIO journal (American Society for Artificial Internal Organs : 1992)\| PubMed ID: 40853322	2026
Rescuing lung transplant candidates with rapidly progressive interstitial lung disease who fail V-V ECMO: A case series of dual veno-arterial and veno-venous extracorporeal membrane oxygenat... JHLT open\| PubMed ID: 41716217	2026
Determining an optimal central cannulation strategy for ambulatory veno-venous extracorporeal life support. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 41949527	2026
Extracorporeal membrane oxygenation as a bridge to lung transplant in the composite lung allocation score era: A single-center experience. JTCVS open\| PubMed ID: 41960062	2026
Expanding the Donor Pool Further-Rapid Recovery Without Pre-implant Reanimation for Combined Heart-Lung Donation After Circulatory Death Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 42069072	2026

Enock Adjei

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