the-trajectory-retinal-microcirculation-imaging-from-angiography-to

The Trajectory of Retinal Microcirculation Imaging: From Angiography to Artificial Intelligence

Retinal and choroidal microcirculation are highly specialized vascular networks essential for vision and are increasingly recognized as indicators of ...

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Medical Sciences

Beyond altitude: reevaluating microvascular adaptations through sexual dimorphism and ethnic diversity.

The prevalence of diabetes and its association with microcirculatory dysfunction presents a significant challenge in contemporary global health. Addressing this nexus is crucial for developing targeted therapeutic interventions.

Interdisciplinary perspectives on diabetes and microcirculatory dysfunction: A global bibliometric analysis.

The integrity and functionality of the hepatic microcirculation are essential for maintaining liver health, which is influenced by sex and genetic background. Understanding these variations is crucial for addressing disparities in liver disease outcomes.

Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice.

The potential for microbial modulation to serve as both a therapeutic and prophylactic strategy against type 2 diabetes mellitus (T2DM)-induced microvasculopathy remains underexplored. We therefore compared the efficacy of the gut-centric herbal formulation Intestinal Flora Balance (IFB, BNFF™), when used for therapeutic reversal, synergistic rescue, or prophylactic protection.

Modulation of gut microbiota by the herbal formulation Intestinal Flora Balance rescues pancreatic and intestinal microvascular dysfunction to alleviate type 2 diabetes mellitus.

Recent research has challenged the viewpoint that pancreatic islets operate independently of surrounding exocrine tissues, revealing a bidirectional blood flow between the endocrine and exocrine pancreas. However, a methodology for simultaneous evaluation of pancreatic microhemodynamics and oxygen profiles remains elusive.

Algorithm-Based Common Microcirculatory Framework for Monitoring and Visualizing the Integrated Pancreatic Microcirculation in Type 2 Diabetes Mellitus Mice.

Renal microvascular dysfunction is a central driver of diabetic kidney disease, yet the potential for rapid therapeutic reversal remains obscure. We investigated the effect of short-term liraglutide on early changes in the renal microcirculation post-induction of diabetes.

Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction.

The microcirculation is a determinant of organ function, translating systemic signals into local physiological responses. However, whether the regulation of microhemodynamics is sexually dimorphic within the pancreas has remained unknown. Here, using a multi-scale approach in healthy mice, we report a sexual dimorphism in pancreatic microhemodynamics that is anatomically restricted to the exocrine compartment, defined by divergent expression of the endothelial marker CD31 and estrogen receptor ERβ, whereas the endocrine islet microvasculature remains conserved between sexes. We demonstrate that microhemodynamic dimorphism is functionally coupled to divergent systemic steroid hormone profiles, a male signature characterized by elevated androgens and steroidogenic precursors, and a female signature dominated by glucocorticoids and estrogen metabolites. The distinction manifests as fundamentally different regulatory principles for vascular control, where pancreatic blood flow in males is directly coupled to systemic blood pressure, whereas in females, the relationship is defined by correlations between blood pressure and the oscillatory components of microhemodynamics. Collectively, our data identify the pancreatic microcirculation as a primary site of physiological sexual dimorphism and establish its role as a fundamental conduit for translating the systemic hormonal milieu into sex-specific organ homeostasis.

Functional Segregation of Pancreatic Microcirculation Reveals Sex-Dependent Microhemodynamic Signatures.

The integrity of the pancreatic islet microvasculature is critical for endocrine function, yet it is progressively compromised by glucotoxicity in diabetes. While matrix metalloproteinases are implicated, the role of stromelysin-1 as a potential upstream driver of endothelial dysfunction remains poorly defined. The aim of our study was to elucidate the role of stromelysin-1 in mediating glucotoxic injury to islet microvascular endothelial cells (IMECs). To this end, we employed a CRISPR/Cas9-mediated knockout of stromelysin-1 in IMECs. Cellular functions, including proliferation, migration, and angiogenesis, were assessed using IncuCyte ZOOM live-cell imaging, while endothelial barrier integrity was quantified via a 40 kDa dextran flux assay. Additionally, the secretome was profiled using a cytokine antibody array. We found that genetic ablation of stromelysin-1 conferred protection against glucotoxicity. Stromelysin-1 KO IMECs exhibited significantly enhanced proliferation, migration, and angiogenic capacity compared to wild-type controls. Furthermore, stromelysin-1 deficiency restored endothelial monolayer integrity by attenuating high-glucose-induced hyperpermeability. These functional improvements were linked to a remodelling of the secretome, characterised by decreased secretion of the pro-degradative MMP-2 and increased secretion of the anti-inflammatory cytokine IL-10 and the endogenous inhibitor TIMP-2. Overall, our findings establish stromelysin-1 as a crucial mediator of glucotoxic injury in islet microvascular endothelial cells.

Article	Year
Beyond altitude: reevaluating microvascular adaptations through sexual dimorphism and ethnic diversity. Lancet regional health. Americas\| PubMed ID: 39816627	2025
Interdisciplinary perspectives on diabetes and microcirculatory dysfunction: A global bibliometric analysis. World journal of diabetes\| PubMed ID: 39959278	2025
Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice. World journal of gastroenterology\| PubMed ID: 40309233	2025
Modulation of gut microbiota by the herbal formulation Intestinal Flora Balance rescues pancreatic and intestinal microvascular dysfunction to alleviate type 2 diabetes mellitus. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 41544466	2026
Algorithm-Based Common Microcirculatory Framework for Monitoring and Visualizing the Integrated Pancreatic Microcirculation in Type 2 Diabetes Mellitus Mice. Journal of diabetes\| PubMed ID: 41635279	2026
Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction. Diabetes, obesity & metabolism\| PubMed ID: 41749403	2026
Functional Segregation of Pancreatic Microcirculation Reveals Sex-Dependent Microhemodynamic Signatures. Comprehensive Physiology\| PubMed ID: 41846427	2026
Consequences of CRISPR-Cas9-Mediated Stromelysin-1 Knockout in Pancreatic Islet Microvascular Endothelial Cells. Journal of cellular and molecular medicine\| PubMed ID: 41860163	2026

Weiqi Liu

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