Jochen H. M. Prehn

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland

Affiliated withRoyal College of Surgeons in Ireland

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Endonuclease-G and the pathways to dopaminergic neurodegeneration: a question of location? The EMBO journal\| PubMed ID: 24162725	2013
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17670970	2007
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. The Journal of biological chemistry\| PubMed ID: 18522940	2008
Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein. Biochimica et biophysica acta\| PubMed ID: 18590777	2008
Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects. PloS one\| PubMed ID: 18665234	2008
Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiology of disease\| PubMed ID: 18804535	2008
Control of motoneuron survival by angiogenin. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19109488	2008
Effects of transient focal cerebral ischemia in mice deficient in puma. Neuroscience letters\| PubMed ID: 19159665	2009
Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. Biochimica et biophysica acta\| PubMed ID: 19167459	2009
Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19261894	2009
Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays. Biochimica et biophysica acta\| PubMed ID: 19285159	2009
Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells. Molecular pharmacology\| PubMed ID: 19713356	2009
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 19890018	2010
Expanding the substantial interactome of NEMO using protein microarrays. PloS one\| PubMed ID: 20098747	2010
Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death. BMC systems biology\| PubMed ID: 20132548	2010
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. The Journal of cell biology\| PubMed ID: 20351066	2010
Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation. Journal of cell science\| PubMed ID: 20356928	2010
The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics. Journal of neurochemistry\| PubMed ID: 20405578	2010
Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability. Journal of neurochemistry\| PubMed ID: 20477911	2010
NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: an in vitro model for the study of neural precursor cell p... Brain research\| PubMed ID: 20478273	2010
BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor. Journal of neurochemistry\| PubMed ID: 20646170	2010
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes\| PubMed ID: 20682686	2010
Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons. Antioxidants & redox signaling\| PubMed ID: 20712420	2011
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. The Journal of biological chemistry\| PubMed ID: 20841353	2010
Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. Molecular and cellular biology\| PubMed ID: 20921277	2010
Mathematical modelling of the mitochondrial apoptosis pathway. Biochimica et biophysica acta\| PubMed ID: 20950651	2011
Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. The European journal of neuroscience\| PubMed ID: 21198986	2011
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. Molecular systems biology\| PubMed ID: 21364572	2011
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 21364604	2011
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mu... The Journal of biological chemistry\| PubMed ID: 21628466	2011
Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer. International journal of cancer\| PubMed ID: 21960357	2012
Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy. Gut\| PubMed ID: 22082587	2012
A structured approach to the study of metabolic control principles in intact and impaired mitochondria. Molecular bioSystems\| PubMed ID: 22218564	2012
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22302823	2012
'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity. Biochimica et biophysica acta\| PubMed ID: 22336583	2012
Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling. The Journal of biological chemistry\| PubMed ID: 22408249	2012
Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22496549	2012
Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization. The Journal of biological chemistry\| PubMed ID: 23038270	2012
Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-ÎºB signaling in neurons. Journal of cell science\| PubMed ID: 23097049	2012
Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase. Frontiers in neuroscience\| PubMed ID: 23181008	2012
AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1. Journal of neurochemistry\| PubMed ID: 23199202	2013
Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy. Cancer research\| PubMed ID: 23329644	2013
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures. Brain : a journal of neurology\| PubMed ID: 23361066	2013
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme. Molecular imaging\| PubMed ID: 23490442	2013
Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions. Methods (San Diego, Calif.)\| PubMed ID: 23607991	2013
Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary. Drug discovery today\| PubMed ID: 23792334	2013
Angiogenin induces modifications in the astrocyte secretome: relevance to amyotrophic lateral sclerosis. Journal of proteomics\| PubMed ID: 23920243	2013
Glucose-starved cells do not engage in prosurvival autophagy. The Journal of biological chemistry\| PubMed ID: 24014036	2013
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons. Cells\| PubMed ID: 35626675	2022
Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis. Journal of cell science\| PubMed ID: 24284067	2014
Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches? Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 24477766	2014
Increased expression of microRNA-29a in ALS mice: functional analysis of its inhibition. Journal of molecular neuroscience : MN\| PubMed ID: 24696165	2014
Validation of an imageable surgical resection animal model of Glioblastoma (GBM). Journal of neuroscience methods\| PubMed ID: 24952322	2014
The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes. Neurobiology of disease\| PubMed ID: 24956542	2014
Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles. Cellular and molecular life sciences : CMLS\| PubMed ID: 25006059	2015
Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25080581	2014
Hsp27 binding to the 3'UTR of bim mRNA prevents neuronal death during oxidative stress-induced injury: a novel cytoprotective mechanism. Molecular biology of the cell\| PubMed ID: 25187648	2014
Anti-apoptotic BCL-2 family proteins in acute neural injury. Frontiers in cellular neuroscience\| PubMed ID: 25324720	2014
"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice. Neurobiology of aging\| PubMed ID: 25443289	2015
Bax regulates neuronal Ca2+ homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25632145	2015
MicroRNA-224 is Readily Detectable in Urine of Individuals with Diabetes Mellitus and is a Potential Indicator of Beta-Cell Demise. Genes\| PubMed ID: 26110317	2015
Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Frontiers in neuroscience\| PubMed ID: 26136652	2015
Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis. The European journal of neuroscience\| PubMed ID: 26750440	2016
Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions. PloS one\| PubMed ID: 26840769	2016
Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers. European journal of nuclear medicine and molecular imaging\| PubMed ID: 26975402	2016
Caspase 6 has a protective role in SOD1(G93A) transgenic mice. Biochimica et biophysica acta\| PubMed ID: 26976329	2016
Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer. European journal of pharmacology\| PubMed ID: 26997367	2016
Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27098698	2016
Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia. eNeuro\| PubMed ID: 27257617	2016
Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer. Journal of translational medicine\| PubMed ID: 27369741	2016
Erratum to: Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer. Journal of translational medicine\| PubMed ID: 27459847	2016
A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice. Disease models & mechanisms\| PubMed ID: 27491077	2016
Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications. Microarrays (Basel, Switzerland)\| PubMed ID: 27600244	2015
A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27649552	2017
BCL-2 system analysis identifies high-risk colorectal cancer patients. Gut\| PubMed ID: 27663504	2017
Advances in immunotherapy for the treatment of glioblastoma. Journal of neuro-oncology\| PubMed ID: 27743144	2017
In the Middle of a Chain Interaction. Molecular cell\| PubMed ID: 27768869	2016
miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions. Bioinformatics (Oxford, England)\| PubMed ID: 27797767	2017
MicroRNAs in epilepsy: pathophysiology and clinical utility. The Lancet. Neurology\| PubMed ID: 27839653	2016
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient... Oncotarget\| PubMed ID: 28178667	2017
NF-κB regulates neuronal ankyrin-G via a negative feedback loop. Scientific reports\| PubMed ID: 28181483	2017
Time-lapse imaging of p65 and IκBα translocation kinetics following Ca-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons. Molecular and cellular neurosciences\| PubMed ID: 28238890	2017
Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok. Neurochemistry international\| PubMed ID: 28315370	2017
Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. Oncotarget\| PubMed ID: 28487489	2017
Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus. Scientific reports\| PubMed ID: 28607431	2017
A constitutively-active IKK-complex at the axon initial segment. Brain research\| PubMed ID: 29079505	2018
Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice. Neuroscience\| PubMed ID: 29129795	2018
Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform. PloS one\| PubMed ID: 29145487	2017
Riluzole does not improve lifespan or motor function in three ALS mouse models. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 29221425	2018
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell death and differentiation\| PubMed ID: 29229998	2018
Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease\| PubMed ID: 29352235	2018
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell death and differentiation\| PubMed ID: 29362479	2018
The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer. Cell death & disease\| PubMed ID: 29374142	2018
Pleiotropic activity of systemically delivered angiogenin in the SOD1 mouse model. Neuropharmacology\| PubMed ID: 29486168	2018
Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer. EBioMedicine\| PubMed ID: 29605508	2018
Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. Journal of neuroinflammation\| PubMed ID: 29720226	2018
Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 29792754	2018
BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Oncotarget\| PubMed ID: 29899841	2018
Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. Scientific reports\| PubMed ID: 30046049	2018
Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 30069746	2018
Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1. Frontiers in cell and developmental biology\| PubMed ID: 30255019	2018
Author Correction: Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. Scientific reports\| PubMed ID: 30262882	2018
ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch". The Journal of biological chemistry\| PubMed ID: 30287689	2018
Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Nature communications\| PubMed ID: 30291241	2018
Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy. EBioMedicine\| PubMed ID: 30396857	2018
Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers. Cancer metastasis reviews\| PubMed ID: 30680581	2019
Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate. Proteomics. Clinical applications\| PubMed ID: 30768761	2019
Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons. Aging cell\| PubMed ID: 30793475	2019
A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic. JCO clinical cancer informatics\| PubMed ID: 30995124	2019
Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y Receptor in Experimental Epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31048325	2019
Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression. Brain stimulation\| PubMed ID: 31208877	2019
Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model. Disease models & mechanisms\| PubMed ID: 31383794	2019
The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia. Frontiers in immunology\| PubMed ID: 31396238	2019
Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform. PLoS computational biology\| PubMed ID: 31553717	2019
Mucin Pools Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Marker of Response or Epiphenomenon? The American journal of surgical pathology\| PubMed ID: 31567193	2020
Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease. Scientific reports\| PubMed ID: 31659197	2019
System-based approaches as prognostic tools for glioblastoma. BMC cancer\| PubMed ID: 31718568	2019
Mucinous adenocarcinoma of the colon and rectum: A genomic analysis. Journal of surgical oncology\| PubMed ID: 31729037	2019
Elevated Plasma microRNA-206 Levels Predict Cognitive Decline and Progression to Dementia from Mild Cognitive Impairment. Biomolecules\| PubMed ID: 31766231	2019
Mucinous adenocarcinoma is a pharmacogenomically distinct subtype of colorectal cancer. The pharmacogenomics journal\| PubMed ID: 31819162	2020
Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis. Autophagy\| PubMed ID: 31826695	2020
Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma. Cancers\| PubMed ID: 31842413	2019
Systems biology analysis identifies molecular determinants of chemotherapy-induced diarrhoea. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 31848663	2020
Circulating miR-330-3p in Late Pregnancy is Associated with Pregnancy Outcomes Among Lean Women with GDM. Scientific reports\| PubMed ID: 31969632	2020
C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis. Aging cell\| PubMed ID: 32100453	2020
Loss of angiogenin function is related to earlier ALS onset and a paradoxical increase in ALS duration. Scientific reports\| PubMed ID: 32111867	2020
Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration. Acta pharmacologica Sinica\| PubMed ID: 32144338	2020
The apoptosome molecular timer synergises with XIAP to suppress apoptosis execution and contributes to prognosticating survival in colorectal cancer. Cell death and differentiation\| PubMed ID: 32341447	2020
Quantification of tRNA fragments by electrochemical direct detection in small volume biofluid samples. Scientific reports\| PubMed ID: 32371908	2020
AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 32393534	2020
Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer. Scientific reports\| PubMed ID: 32555399	2020
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 32581127	2020
Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway. Carcinogenesis\| PubMed ID: 32628753	2020
Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer. International journal of cancer\| PubMed ID: 32700762	2020
Mucinous Adenocarcinoma of the Rectum: A Whole Genome Sequencing Study. Frontiers in oncology\| PubMed ID: 32984045	2020
Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models. Cancers\| PubMed ID: 33066609	2020
Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells. Frontiers in cell and developmental biology\| PubMed ID: 33240888	2020
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell death & disease\| PubMed ID: 33257690	2020
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study. Cell death and differentiation\| PubMed ID: 33328572	2021
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science advances\| PubMed ID: 33523897	2021
5'ValCAC tRNA fragment generated as part of a protective angiogenin response provides prognostic value in amyotrophic lateral sclerosis. Brain communications\| PubMed ID: 33543130	2020
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 33609732	2021
Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer. The FEBS journal\| PubMed ID: 33660894	2021
AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling. Journal of neurochemistry\| PubMed ID: 33694332	2021
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling. BMC biology\| PubMed ID: 33761951	2021
Resistance to Cell Death in Mucinous Colorectal Cancer-A Review. Cancers\| PubMed ID: 33808549	2021
The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL. Blood advances\| PubMed ID: 33830207	2021
Mucinous Colorectal Cancer is Associated With Expression of the TIM-3 Immune Checkpoint Independently of Microsatellite Instability (MSI) Status. Annals of surgical oncology\| PubMed ID: 33876348	2021
An Insight Into the Driver Mutations and Molecular Mechanisms Underlying Mucinous Adenocarcinoma of the Rectum. Diseases of the colon and rectum\| PubMed ID: 33955407	2021
Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells\| PubMed ID: 34066147	2021
BCL(X)L and BCL2 increase mitochondrial dynamics in breast cancer cell: Evidence from functional and genetic studies. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 34214511	2021
tRNA-derived fragments: A new class of non-coding RNA with key roles in nervous system function and dysfunction. Progress in neurobiology\| PubMed ID: 34245849	2021
tsRNAsearch: a pipeline for the identification of tRNA and ncRNA fragments from small RNA-sequencing data. Bioinformatics (Oxford, England)\| PubMed ID: 34255836	2021
Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 34426441	2021
Patients with mesenchymal tumours and high prevalence have worse prognosis in colorectal cancer (CRC). Gut\| PubMed ID: 34497144	2022
TRAIL signaling promotes entosis in colorectal cancer. The Journal of cell biology\| PubMed ID: 34546352	2021
FLINO: a new method for immunofluorescence bioimage normalization. Bioinformatics (Oxford, England)\| PubMed ID: 34601553	2022
Mitochondrial Carrier Homolog 2 Functionally Co-operates With BH3 Interacting-Domain Death Agonist in Promoting Ca-Induced Neuronal Injury. Frontiers in cell and developmental biology\| PubMed ID: 34708044	2021
Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 34732839	2022
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution. Cell death and differentiation\| PubMed ID: 34754079	2022
Comparative analysis of CI- and CIV-containing respiratory supercomplexes at single-cell resolution. Cell reports methods\| PubMed ID: 35474694	2021
Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis. Molecular and cellular biochemistry\| PubMed ID: 35583632	2022
Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain. American journal of physiology. Cell physiology\| PubMed ID: 35613354	2022
Apoptotic and Necroptotic Mediators are Differentially Expressed in Mucinous and Non-Mucinous Colorectal Cancer. Frontiers in oncology\| PubMed ID: 35912268	2022
BOK controls ER proteostasis and physiological ER stress responses in neurons. Frontiers in cell and developmental biology\| PubMed ID: 36060797	2022
Effect of deficiency and signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study. Frontiers in cell and developmental biology\| PubMed ID: 36238683	2022
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications. Cell death & disease\| PubMed ID: 36261424	2022
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer. Molecular cancer therapeutics\| PubMed ID: 36279564	2023
Multiplexed Immunofluorescence Imaging Reveals an Immune-Rich Tumor Microenvironment in Mucinous Rectal Cancer Characterized by Increased Lymphocyte Infiltration and Enhanced Programmed Cell... Diseases of the colon and rectum\| PubMed ID: 36525395	2023
Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuron... Computational and structural biotechnology journal\| PubMed ID: 36618980	2023
Fluorescence Time-lapse Imaging of Entosis Using Tetramethylrhodamine Methyl Ester Staining. Bio-protocol\| PubMed ID: 36620081	2022
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications\| PubMed ID: 37059720	2023
Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell death and differentiation\| PubMed ID: 37100955	2023
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 37171483	2023
Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors. Journal of neuro-oncology\| PubMed ID: 37237151	2023
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes. Purinergic signalling\| PubMed ID: 37453017	2024
Corrigendum: Mucinous adenocarcinoma of the rectum: a whole genome sequencing study. Frontiers in oncology\| PubMed ID: 37456242	2023
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers. British journal of cancer\| PubMed ID: 37620410	2023
Chlorpromazine affects autophagy in association with altered Rag GTPase-mTORC1-TFEB signaling. Frontiers in cell and developmental biology\| PubMed ID: 37745295	2023
Integrated analysis of transcriptomic and proteomic alterations in mouse models of ALS/FTD identify early metabolic adaptions with similarities to mitochondrial dysfunction disorders. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 37779364	2024
Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics. Scientific reports\| PubMed ID: 37952048	2023
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells. International journal of molecular sciences\| PubMed ID: 37958662	2023
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle. Neuron\| PubMed ID: 38266647	2024
Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients. bioRxiv : the preprint server for biology\| PubMed ID: 38352309	2024
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development. Cellular & molecular biology letters\| PubMed ID: 38448800	2024
Identification of unique rectal cancer-specific subtypes. British journal of cancer\| PubMed ID: 38532103	2024
Meta-analysis of SATB2 immunohistochemical expression in colorectal cancer versus primary ovarian mucinous neoplasms. Annals of diagnostic pathology\| PubMed ID: 38642469	2024
Spatial transcriptomic analysis reveals local effects of intratumoral fusobacterial infection on DNA damage and immune signaling in rectal cancer. Gut microbes\| PubMed ID: 38709233	2024
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice. Brain, behavior, and immunity\| PubMed ID: 38777288	2024
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction. Acta pharmaceutica Sinica. B\| PubMed ID: 38799643	2024
Distinct fingerprints of tRNA-derived small non-coding RNA in animal models of neurodegeneration. Disease models & mechanisms\| PubMed ID: 39552337	2024
Effects of ALS-associated 5'tiRNA on the transcriptomic and proteomic profile of primary neurons in vitro. Experimental neurology\| PubMed ID: 39719207	2025
Protective role of Angiogenin in muscle regeneration in amyotrophic lateral sclerosis: Diagnostic and therapeutic implications. Brain pathology (Zurich, Switzerland)\| PubMed ID: 39731449	2025
SATB2 Expression Affects Chemotherapy Metabolism and Immune Checkpoint Gene Expression in Colorectal Cancer. Clinical colorectal cancer\| PubMed ID: 39794188	2025
Corrigendum to "Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice" [Brain Behav. Immun. 120 (2024) 121-140]. Brain, behavior, and immunity\| PubMed ID: 40713463	2025
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure. Nature communications\| PubMed ID: 40721560	2025
Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin. The pharmacogenomics journal\| PubMed ID: 41044076	2025
Serum small non-coding RNA define molecular subtypes in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 41175163	2026
In vitro identification of kainic acid-induced, concentration-dependent responses in human cortical neuronal networks. Neuroscience\| PubMed ID: 41290070	2026
Loss of SATB2 in colorectal cancer is associated with inferior survival and adverse clinicopathologic features: a meta-analysis. American journal of clinical pathology\| PubMed ID: 41317386	2026
Modeling the microRNA regulation of TGF-β/SMAD signaling pathways for seizure control in temporal lobe epilepsy. NPJ systems biology and applications\| PubMed ID: 41540052	2026
p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control. Aging cell\| PubMed ID: 41674118	2026
Biofluid-specific variations in circulating 5' transfer RNA fragments during ictal and interictal states in experimental temporal lobe epilepsy. Epilepsia\| PubMed ID: 41973185	2026
A pipeline of machine learning-driven multi-modal data fusion methods for prognostic risk analysis in bevacizumab-treated metastatic colorectal cancer. Scientific reports\| PubMed ID: 41974756	2026
Neuronal vulnerability in Parkinson's disease: insights from murine α-synuclein pathology models. Neuroscience\| PubMed ID: 42002068	2026
Small RNA sequencing identifies serum tDR-1:34-Gly-GCC tiRNA levels as a biomarker for survival in amyotrophic lateral sclerosis. iScience\| PubMed ID: 42063547	2026