Heiko Dussmann

Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland

Affiliated withRoyal College of Surgeons in Ireland

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. The EMBO journal\| PubMed ID: 16932741	2006
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17670970	2007
Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation. The Journal of biological chemistry\| PubMed ID: 18522940	2008
Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein. Biochimica et biophysica acta\| PubMed ID: 18590777	2008
Bid and calpains cooperate to trigger oxaliplatin-induced apoptosis of cervical carcinoma HeLa cells. Molecular pharmacology\| PubMed ID: 19713356	2009
ALISSA: an automated live-cell imaging system for signal transduction analyses. BioTechniques\| PubMed ID: 20041856	2009
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes\| PubMed ID: 20682686	2010
Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release. Molecular systems biology\| PubMed ID: 21364572	2011
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mu... The Journal of biological chemistry\| PubMed ID: 21628466	2011
A structured approach to the study of metabolic control principles in intact and impaired mitochondria. Molecular bioSystems\| PubMed ID: 22218564	2012
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22302823	2012
Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22496549	2012
Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization. The Journal of biological chemistry\| PubMed ID: 23038270	2012
AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1. Journal of neurochemistry\| PubMed ID: 23199202	2013
Single-cell imaging of the heat-shock response in colon cancer cells suggests that magnitude and length rather than time of onset determines resistance to apoptosis. Journal of cell science\| PubMed ID: 24284067	2014
Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25080581	2014
Bax regulates neuronal Ca2+ homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25632145	2015
Versatile Conjugated Polymer Nanoparticles for High-Resolution O2 Imaging in Cells and 3D Tissue Models. ACS nano\| PubMed ID: 25858428	2015
Time-lapse imaging of p65 and IκBα translocation kinetics following Ca-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons. Molecular and cellular neurosciences\| PubMed ID: 28238890	2017
Single-cell time-lapse imaging of intracellular O in response to metabolic inhibition and mitochondrial cytochrome-c release. Cell death & disease\| PubMed ID: 28569778	2017
Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform. PloS one\| PubMed ID: 29145487	2017
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell death and differentiation\| PubMed ID: 29229998	2018
Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells. Cell death & disease\| PubMed ID: 29352235	2018
BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose. Oncotarget\| PubMed ID: 29899841	2018
Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1. Frontiers in cell and developmental biology\| PubMed ID: 30255019	2018
ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch". The Journal of biological chemistry\| PubMed ID: 30287689	2018
The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia. Frontiers in immunology\| PubMed ID: 31396238	2019
AMPK Preferentially Depresses Retrograde Transport of Axonal Mitochondria during Localized Nutrient Deprivation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 32393534	2020
Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant. Cell death & disease\| PubMed ID: 33257690	2020
BCL(X)L and BCL2 increase the metabolic fitness of breast cancer cells: a single-cell imaging study. Cell death and differentiation\| PubMed ID: 33328572	2021
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science advances\| PubMed ID: 33523897	2021
AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling. Journal of neurochemistry\| PubMed ID: 33694332	2021
Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM. Cells\| PubMed ID: 34066147	2021
BCL(X)L and BCL2 increase mitochondrial dynamics in breast cancer cell: Evidence from functional and genetic studies. Biochimica et biophysica acta. Molecular cell research\| PubMed ID: 34214511	2021
TRAIL signaling promotes entosis in colorectal cancer. The Journal of cell biology\| PubMed ID: 34546352	2021
Mitochondrial Carrier Homolog 2 Functionally Co-operates With BH3 Interacting-Domain Death Agonist in Promoting Ca-Induced Neuronal Injury. Frontiers in cell and developmental biology\| PubMed ID: 34708044	2021
BOK controls ER proteostasis and physiological ER stress responses in neurons. Frontiers in cell and developmental biology\| PubMed ID: 36060797	2022
Effect of deficiency and signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study. Frontiers in cell and developmental biology\| PubMed ID: 36238683	2022
Fluorescence Time-lapse Imaging of Entosis Using Tetramethylrhodamine Methyl Ester Staining. Bio-protocol\| PubMed ID: 36620081	2022
Increased Fusobacterium tumoural abundance affects immunogenicity in mucinous colorectal cancer and may be associated with improved clinical outcome. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 37171483	2023
Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors. Journal of neuro-oncology\| PubMed ID: 37237151	2023
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture. EMBO reports\| PubMed ID: 37501540	2023
Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients. bioRxiv : the preprint server for biology\| PubMed ID: 38352309	2024
Spatial transcriptomic analysis reveals local effects of intratumoral fusobacterial infection on DNA damage and immune signaling in rectal cancer. Gut microbes\| PubMed ID: 38709233	2024
Spatial effects of infiltrating T cells on neighbouring cancer cells and prognosis in stage III CRC patients. The Journal of pathology\| PubMed ID: 39092716	2024
Serine-arginine protein kinase 1 (SRPK1) is under-expressed in mucinous colorectal cancer, and may mediate resistance to oxaliplatin. The pharmacogenomics journal\| PubMed ID: 41044076	2025