development-validation-rapid-lc-msms-method-for-carfilzomib

Development and Validation of a Rapid LC-MS/MS Method for Carfilzomib Quantification in Plasma from Multiple Myeloma Patients

Carfilzomib, a second-generation proteasome inhibitor, requires therapeutic drug monitoring (TDM). This study aimed to develop and validate a sensitive ...

Second Affiliated Hospital of Naval Medical University

Diarrhea is the primary dose-limiting side effect of capecitabine(Cap) hindering its clinical application, but the mechanism is unclear. Clarifying this mechanism may enhance the patient compliance and improve the treatment outcome.

Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway.

To establish a rapid and universal quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) method for measuring the exposure levels of five triazole antifungal drugs in human plasma, including voriconazole, fluconazole, posaconazole, itraconazole, and hydroxyitraconazole.

A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients.

To develop a simple, rapid, and sensitive LC-MS/MS method for quantifying 23 tyrosine kinase inhibitors (TKIs) in plasma samples, and evaluate the relationship between the trough concentration of anlotinib(ANL) and its toxicities.

LC-MS/MS method for quantification of 23 TKIs in Plasma: Assessing the relationship between anlotinib trough concentration and toxicities.

Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism is obscure. This study was designed to explore the mechanism of Sch B against colorectal cancer (CRC).

Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway.

Corrigendum to "Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway" [J. Adv. Res. 72 (2025) 591-604].

The purpose of this study was to investigate the exposure-toxicity relationship between anlotinib (ANL) and the hand-foot syndrome (HFS) and to establish an early warning model of ANL-induced HFS based on exposure level and metabolomics. The cancer patients treated with ANL were enrolled in a prospective cohort study. Plasma samples were collected at baseline and steady-state trough concentration points. Exposure concentrations of ANL were examined and the exposure-toxicity relationship was analyzed. The untargeted metabolomics was carried out and the early warning model was constructed using binary logistic regression. Totally 65 lung cancer patients were enrolled and the steady-state trough concentration of ANL was 13.8 ± 7.8 (mean±SD). The occurrence of HFS wasn't associated with ANL exposure concentration. Untargeted metabolomics revealed 6 differential metabolites in baseline samples from patients with or without HFS, and 28 differential metabolites were identified in baseline samples from patients with grade ≥ 2 or grade < 2 HFS, allowing to distinguish between patients with or without grade ≥ 2 HFS. A logistic regression model Y= 0.107*Tromethamine-1.447*(6,9-Dioxo-Decanoic acid) + 5.697*(9-O-Acetylneuraminic acid) + 161.586 (AUC=0.958, 95 % CI: 0.878-1.000, P < 0.0001) for early warning of grade ≥ 2 HFS was constructed. HFS didn't correlated to ANL steady-state trough concentration. Disturbed baseline metabolic profiles showed close association with ANL-induced HFS, resulting an early warning model which may improve the clinical application of ANL after verification with large sample size.

Article	Year
Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway. Journal of advanced research\| PubMed ID: 39048073	2025
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients. Journal of pharmacological and toxicological methods\| PubMed ID: 39321943	2024
LC-MS/MS method for quantification of 23 TKIs in Plasma: Assessing the relationship between anlotinib trough concentration and toxicities. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 39547553	2025
Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway. Cancer cell international\| PubMed ID: 40089741	2025
Corrigendum to "Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway" [J. Adv. Res. 72 (2025) 591-604]. Journal of advanced research\| PubMed ID: 40592668	2025
Discovery of a predictive model for anlotinib-induced hand-foot syndrome based on metabolomics. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 41167105	2026
Exploring potential biomarkers and constructing prediction models of osimertinib based on a retrospective study. European journal of clinical pharmacology\| PubMed ID: 41724848	2026

Mao Tang

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