Weiwei Li

Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University

Affiliated withGuizhou Medical University

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences\| PubMed ID: 28477535	2017
Development of Polyclonal Antibodies for Detection of Diosbulbin B-Derived cis-Enedial Protein Adducts. Chemical research in toxicology\| PubMed ID: 29569913	2018
A Difference in Internal Exposure Makes Newly Weaned Mice More Susceptible to the Hepatotoxicity of Retrorsine Than Adult Mice. Chemical research in toxicology\| PubMed ID: 30427168	2018
In Vitro DNA Adduction Resulting from Metabolic Activation of Diosbulbin B and 8-Epidiosbulbin E Acetate. Chemical research in toxicology\| PubMed ID: 30520628	2019
Clinical Characteristics of 1378 Inpatients with Spinal Tuberculosis in General Hospitals in South-Central China. BioMed research international\| PubMed ID: 30941375	2019
Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial-mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling. Molecular carcinogenesis\| PubMed ID: 30977227	2019
SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. Gene\| PubMed ID: 31357026	2019
Analysis of the Volatile Components in Selaginella doederleinii by Headspace Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry. Molecules (Basel, Switzerland)\| PubMed ID: 31892247	2019
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 32315674	2020
Immunochemical Detection of Protein Modification Derived from Metabolic Activation of 8-Epidiosbulbin E Acetate. Chemical research in toxicology\| PubMed ID: 32347100	2020
Metabolic Activation of Pirfenidone Mediated by Cytochrome P450s and Sulfotransferases. Journal of medicinal chemistry\| PubMed ID: 32643929	2020
and Evidence for RNA Adduction Resulting from Metabolic Activation of Methyleugenol. Journal of agricultural and food chemistry\| PubMed ID: 33296206	2020
Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine. Journal of environmental science and health. Part C, Toxicology and carcinogenesis\| PubMed ID: 33382013	2020
Ultrasonic-Assisted Ionic Liquid Extraction of Two Biflavonoids from . ACS omega\| PubMed ID: 33403273	2020
Mechanistic study of bergamottin-induced inactivation of CYP2C9. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 34019943	2021
Mushroom Poisoning Outbreaks - China, 2010-2020. China CDC weekly\| PubMed ID: 34594925	2021
Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties. Biomedical chromatography : BMC\| PubMed ID: 34727371	2022
RNA adduction derived from electrophilic species in vitro and in vivo. Chemico-biological interactions\| PubMed ID: 34801539	2022
Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases. Toxicology letters\| PubMed ID: 35331839	2022
A Metabolic Activation-Based Chemoproteomic Platform to Profile Adducted Proteins Derived from Furan-Containing Compounds. ACS chemical biology\| PubMed ID: 35353477	2022
DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo. Toxicology and applied pharmacology\| PubMed ID: 35367474	2022
Metabolic Activation of Militarine In Vitro and In Vivo. Chemical research in toxicology\| PubMed ID: 35476398	2022
2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene. Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 35575452	2022
Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 35660353	2022
Characteristics and Outcomes of Shared Bicycle-Related Injuries from a Large Emergency Medical Centre in China, 2017-2021. Emergency medicine international\| PubMed ID: 35784642	2022
Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate and . Chemical research in toxicology\| PubMed ID: 35839447	2022
Hepatic RNA adduction derived from metabolic activation of retrorsine in vitro and in vivo. Chemico-biological interactions\| PubMed ID: 35917946	2022
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN. Journal of receptor and signal transduction research\| PubMed ID: 36043996	2022
2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo. Chemico-biological interactions\| PubMed ID: 36332690	2022
Evaluating and predicting the correlations of hepatic concentration and pyrrole-protein adduction with hepatotoxicity induced by retrorsine based on pharmacokinetic/pharmacodynamic model. Toxicology letters\| PubMed ID: 36464202	2023
Configurational Alteration Results in Change in Hepatotoxicity of Asarone. Journal of agricultural and food chemistry\| PubMed ID: 36584355	2023
Correlational Analysis of the Physicochemical Indexes, Volatile Flavor Components, and Microbial Communities of High-Temperature in the Northern Region of China. Foods (Basel, Switzerland)\| PubMed ID: 36673417	2023
Metabolic Activation of Pesticide Isoprocarb Mediated by CYP3A4 and the Possible Correlation with Its Cytotoxicity. Journal of agricultural and food chemistry\| PubMed ID: 36706223	2023
Inflammation Intensifies Monocrotaline-Induced Liver Injury. Journal of agricultural and food chemistry\| PubMed ID: 36753335	2023
In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A. Chemical research in toxicology\| PubMed ID: 36795936	2023
Glycyrrhetinic acid ameliorates diosbulbin B-induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B. Journal of applied toxicology : JAT\| PubMed ID: 36807597	2023
Formation of RNA adducts resulting from metabolic activation of spice ingredient safrole mediated by P450 enzymes and sulfotransferases. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 36841326	2023
Mechanistic Study of Xanthotoxin-Mediated Inactivation of CYP1A2 and Related Drug-Drug Interaction with Tacrine. Chemical research in toxicology\| PubMed ID: 36892569	2023
DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo. Toxicology letters\| PubMed ID: 36905973	2023
Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo. Chemical research in toxicology\| PubMed ID: 36976707	2023
Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 36990007	2023
Difference in hepatotoxicity of furan-containing components in cortex dictamni correlates the efficiency of their metabolic activation. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 36996529	2023
Metabolic activation and cytotoxicity of 4-methylquinoline mediated by CYP3A4 and sulfotransferases in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 37268085	2023
Recent Advances in Mass Spectrometry-Based Spatially Resolved Molecular Imaging of Drug Disposition and Metabolomics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 37295949	2023
Evidence for the Metabolic Activation of Deferasirox and . Chemical research in toxicology\| PubMed ID: 37435843	2023
Metabolic activation and cytotoxicity of metaxalone mediated by cytochrome P450 enzymes and sulfotransferases. Chemico-biological interactions\| PubMed ID: 37442290	2023
Etiological Survey and Traceability Analysis of a Foodborne Disease Outbreak of Senftenberg in Guizhou Province. Foodborne pathogens and disease\| PubMed ID: 37471209	2023
Glutathione conjugation and protein modification resulting from metabolic activation of pesticide metalaxyl in vitro and in vivo. Pesticide biochemistry and physiology\| PubMed ID: 37945228	2023
Dihydrotanshinone I-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 38123940	2024
Mechanism-Based Inactivation of CYP2D6 by Phellopterin and Related Drug-Drug Interaction with Metoprolol. Journal of agricultural and food chemistry\| PubMed ID: 38214270	2024
Mechanism-based cytotoxicity trend prediction of furan-containing pollutants present in a mixture. Environmental pollution (Barking, Essex : 1987)\| PubMed ID: 38325514	2024
Chelerythrine Chloride is an Affinity-Labeling Inactivator of CYP3A4 by Modification of Cysteine239. Journal of medicinal chemistry\| PubMed ID: 38330258	2024
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A. Archives of toxicology\| PubMed ID: 38369618	2024
LC-MS based untargeted metabolomics studies of the metabolic response of Ginkgo biloba extract on arsenism patients. Ecotoxicology and environmental safety\| PubMed ID: 38471343	2024
Metabolic Activation and Cytotoxicity of Gramine Mediated by CYP3A in Rats. Journal of agricultural and food chemistry\| PubMed ID: 38691522	2024
Identification of an Epoxide Metabolite of Amitriptyline and . Chemical research in toxicology\| PubMed ID: 38761382	2024
Arsenite-Induced Drug-Drug Interactions in Rats. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 38849209	2024
CYP3A4-Mediated Metabolic Activation and Cytotoxicity of Chlortoluron. Chemical research in toxicology\| PubMed ID: 38885202	2024
RNA Adduction Resulting from the Metabolic Activation of Myristicin by P450 Enzymes and Sulfotransferases. Journal of agricultural and food chemistry\| PubMed ID: 38959404	2024
Correlation of Vanillin-Induced Cytotoxicity with CYP3A-Mediated Metabolic Activation. Journal of agricultural and food chemistry\| PubMed ID: 39196852	2024
Enhancing Aromaticity of Alkenylbenzenes May Decrease Their Metabolic Activation and Reduce Their Potential Cytotoxicity: Lessons Learnt from the Investigation of Myristicin and Elemicin. Journal of medicinal chemistry\| PubMed ID: 39442078	2024
Metabolic Activation and Cytotoxicity of Donepezil Induced by CYP3A4. Chemical research in toxicology\| PubMed ID: 39545607	2024
Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes. Toxicology letters\| PubMed ID: 39793773	2025
Mechanistic Understanding of Differences in Cytotoxicity Induced by Food Additives Methyleugenol and Methylisoeugenol. Journal of agricultural and food chemistry\| PubMed ID: 39836452	2025
Metabolic Activation of Stiripentol Correlates with Cytotoxicity. Chemical research in toxicology\| PubMed ID: 39924957	2025
Metabolic activation and cytotoxicity of ibudilast mediated by CYP3A4. Archives of toxicology\| PubMed ID: 40021515	2025
Metabolic Activation of -Anethole Plays a Role in Hepatic Cytotoxicity in Mice. Journal of agricultural and food chemistry\| PubMed ID: 40069955	2025
Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2. Autophagy\| PubMed ID: 40205686	2025
Disruption of Acetyl-CoA Acyltransferase 2 Resulting from Exposure to Diosbulbin B. Chemical research in toxicology\| PubMed ID: 40213991	2025
Metabolic activation and cytotoxicity of carvedilol mediated by cytochrome P450s in vitro and in vivo. Archives of toxicology\| PubMed ID: 40380998	2025
Histones H2B/H3 Selectively Modified by a -Enedial Metabolite Resulting from the Metabolic Action of Diosbulbin B: Potential Target Proteins for the Antitumor Agent Design. Journal of medicinal chemistry\| PubMed ID: 40576305	2025
Epidemiological features of nontyphoidal Salmonella infections reported to foodborne disease surveillance system in china, 2013-2022. BMC public health\| PubMed ID: 40604662	2025
Metabolic activation and cytotoxicity of bavachin mediated by CYP3A in mice. Chemico-biological interactions\| PubMed ID: 40609922	2025
8-Epidiosbulbin E acetate triggers apoptosis via metabolic activation-mediated crosstalk between mitochondria and endoplasmic reticulum. Ecotoxicology and environmental safety\| PubMed ID: 40627913	2025
Mechanistic Insights into CYP2A6 Inactivation by Visnagin and Its Impact on Pharmacokinetic Properties of Tegafur. Chemical research in toxicology\| PubMed ID: 40696501	2025
Laboratory-Simulated UV-Triggered Transformation of Ambroxol in Aquatic Environments: Photoproduct Characterization and Ecological Risk to Model Aquatic Species. Environmental science & technology\| PubMed ID: 40925874	2025
Updated efficacy and predictive biomarkers of QL1706, a bifunctional PD-1/CTLA-4 dual blocker in advanced solid tumors-A phase 1/1b study. Cell reports. Medicine\| PubMed ID: 41045933	2025
Metabolic activation, hepatic protein covalent binding, and cytotoxicity of arctigenin. Toxicology letters\| PubMed ID: 41325899	2025
Mechanistic Insight into Difference in Hepatotoxicity of Methyleugenol and Safrole. Journal of agricultural and food chemistry\| PubMed ID: 41605223	2026
Pyrazinamide-induced hepatotoxicity mediated by aldehyde oxidase and xanthine oxidase. Archives of toxicology\| PubMed ID: 41653207	2026
Protein covalent modification and hepatic cytotoxicity of atorvastatin resulting from its metabolic activation. Archives of toxicology\| PubMed ID: 41677906	2026
Mechanism-based inactivation of CYP2C19 by bicuculline and related alteration in pharmacokinetics of clopidogrel. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 41689871	2026
Predicting Postoperative Survival in Patients With Malignant Biliary Obstruction Using an Interpretable Machine Learning Model: A Multicenter Study. Cancer medicine\| PubMed ID: 41789602	2026
Lysine- and cysteine-based protein adduction resulting from metabolic activation of fraxinellone in Dictamni Cortex. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 41855595	2026
Retrorsine Induces Hepatotoxicity through ATF3-Mediated Ferroptosis in Mouse Primary Hepatocytes and -HepG2 Cells. Journal of agricultural and food chemistry\| PubMed ID: 41891845	2026
In vitro and in vivo metabolic activation of diaveridine mediated by CYP3A. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 41935817	2026
Mechanism-Based Inactivation of CYP2C19 by Anwuligan Resulting in Changes in Pharmacokinetic Properties of Amitriptyline. Chemical research in toxicology\| PubMed ID: 41968488	2026
pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy. iScience\| PubMed ID: 42006369	2026
Evidence for endogenous amine conjugation and cytotoxicity arising from metabolic activation of trazodone. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 42025144	2026
Exploring the components of hepatotoxicity induced by Buch.-Ham. based on integrated network toxicology, metabolomics, and experiments. Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 42091236	2026
Rosiglitazone hepatotoxicity resulting from hepatic protein covalent binding derived from its aldehyde metabolite. Archives of toxicology\| PubMed ID: 42128922	2026