is-teicoplanin-resistance-detected-automated-system-staphylococcus

Is Teicoplanin Resistance Detected By The Automated System In <em>Staphylococcus</em> spp Strains Reliable?

A total of 467 Staphylococcus aureus (S. aureus) and 66 coagulase-negative Staphylococcus (CoNS) isolates collected between June 2022 and December 2024 ...

changes-lower-respiratory-tract-bacterial-isolates-icu-patients

Changes In Lower Respiratory Tract Bacterial Isolates In ICU Patients Before and After the COVID-19 Pandemic

To compare the distribution of bacterial pathogens isolated from lower respiratory tract specimens in COVID-19&#8211;negative intensive care unit patients ...

Harran University

University of Harran Faculty of Medicine

Hyperkeratotic cutaneous leishmaniasis: A rare presentation.

There are limited data on the prevalence of the hepatitis B virus (HBV) infection in the agricultural population worldwide.

Epidemiology of hepatitis B in the reproductive-age female farmworkers of southeastern Turkey.

Cutaneous leishmaniasis (CL) is endemic in Southeastern Anatolia, mainly in Sanliurfa and Hatay provinces, and the causative agents are mostly Leishmania tropica and less frequently L. infantum. Here, we report the first MALDI-TOF analyses of Leishmania promastigotes obtained from the cultures of two CL cases from Osmaniye and Hatay provinces who were initially diagnosed by microscopy, culture and identified as L. infantum with Real-Time PCR (RT-PCR).

Leishmaniasis in Turkey: Determination of Leishmania Species by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS).

The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria.

Detection of Plasmodium using filter paper and nested PCR for patients with malaria in Sanliurfa, in Turkey.

Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility.

Cardiovascular risk may be increased in women with unexplained infertility.

 Four novel thymol-benzimidazolium-chalcone hybrids were designed based on a molecular hybridization strategy that integrates bioactive scaffolds known for their antimicrobial and antioxidant properties. This approach aims to enhance biological activity through synergistic effects and multi-target interactions, as supported by previous studies on phenolic and benzimidazole derivatives. The inclusion of both antioxidant and antibacterial evaluations was motivated by the well-established role of oxidative stress in bacterial pathogenicity and resistance mechanisms.  Their antibacterial potential was initially screened using the disk diffusion method and subsequently evaluated by determining MIC and MBC values against eight clinical  isolates.  Among the tested compounds, compound  emerged as the most potent derivative, exhibiting MIC values ranging from 0.25 to 1 µg/mL. Morphological analysis confirmed significant disruption of bacterial cell integrity, and further investigation demonstrated strong antibiofilm activity accompanied by downregulation of key biofilm- and resistance-associated genes (, , and ). Molecular docking studies were performed against selected target proteins, including 1MWT, 3VSL, 3ZG5 (sortase A), and 2ZCS, which are associated with bacterial cell wall biosynthesis, DNA replication, virulence, and metabolic pathways. Compound  exhibited the highest binding affinity, with a docking score of -11.953 kcal/mol against 2ZCS.  Overall, these findings highlight the potential of thymol-based benzimidazolium-chalcone hybrids as promising multifunctional agents with combined antibacterial, antibiofilm, and antioxidant properties.

Antibacterial and Antibiofilm Potential of Thymol-Benzimidazolium-Chalcone Hybrids Against Clinical MRSA Strains: Insights from Gene Expression Profiling and Molecular Docking.

ArticleTotal : 2	Year
Publication title	2026
Publication title	2026

Article	Year
Hyperkeratotic cutaneous leishmaniasis: A rare presentation. Balkan medical journal\| PubMed ID: 25207085	2013
Epidemiology of hepatitis B in the reproductive-age female farmworkers of southeastern Turkey. Hepatitis monthly\| PubMed ID: 25598790	2014
Leishmaniasis in Turkey: Determination of Leishmania Species by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS). Iranian journal of parasitology\| PubMed ID: 25848391	2014
Detection of Plasmodium using filter paper and nested PCR for patients with malaria in Sanliurfa, in Turkey. Malaria journal\| PubMed ID: 27234320	2016
Cardiovascular risk may be increased in women with unexplained infertility. Clinical and experimental reproductive medicine\| PubMed ID: 28428941	2017
Antibacterial and Antibiofilm Potential of Thymol-Benzimidazolium-Chalcone Hybrids Against Clinical MRSA Strains: Insights from Gene Expression Profiling and Molecular Docking. Antibiotics (Basel, Switzerland)\| PubMed ID: 42192699	2026

Fadile Yildiz Zeyrek

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