changes-lower-respiratory-tract-bacterial-isolates-icu-patients

Changes In Lower Respiratory Tract Bacterial Isolates In ICU Patients Before and After the COVID-19 Pandemic

To compare the distribution of bacterial pathogens isolated from lower respiratory tract specimens in COVID-19&#8211;negative intensive care unit patients ...

University of Harran Faculty of Medicine

The genito-urinary system is one of the most common areas of involvement in brucellosis. To present the epidemiological, clinical, and laboratory characteristics of patients with testicular involvement associated with brucellosis, together with the diagnostic and therapeutic approaches.

Testicular involvement of Brucellosis: A 10-year, multicentre study.

To investigate the prevalence of hematologic findings and the relationship between hemogram parameters and brucellosis stages in patients.

Investigation of hematologic findings related to brucellosis in Anatolian region.

To identify possible drug-drug interactions in patients taking medications for other comorbidities while on antiviral therapy for chronic hepatitis B.

Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B.

Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis.

Predictive Significance of Laboratory Tests in Bacteremic Brucellosis.

Extrapulmonary tuberculosis (EPTB) is an important public health problem due to its diverse clinical presentations, diagnostic complexities, and significant impact on patient outcomes and public health. Our study aimed to understand the sociodemographic, clinical, and laboratory characteristics as well as diagnostic and treatment modalities of adult patients with EPTB. This is a multicentric retrospective study that covers patients with EPTB cases followed up from January 2015 to December 2022 among tuberculosis (TB) dispensaries and Infectious Diseases and Clinical Microbiology clinics of 15 hospitals located in various regions of Turkey. The study included 64.6% women with a mean age of 44 years and a mortality rate of 3.5% within 1 year of diagnosis. Initial constitutional symptoms were predominantly fatigue (57%) and anorexia (53.7%). The most commonly affected sites were the lymph nodes (49.1%) and pleura (9.7%). The lumbar region was particularly involved in cases with spinal TB. Diagnostic findings included acid-fast bacilli positivity in 27.5% of cases, tuberculosis polymerase chain reaction positivity in 41%, elevated adenosine deaminase levels in 91.2% (especially in pleural and peritoneal fluids), and mycobacterial culture positivity in 40.9%. Pathology slides showed granulomatous inflammation in 97.7%. Increased C-reactive protein (CRP) levels correlated with the number of organs affected. Anti-TB treatment-related hepatotoxicity was detected in 8.9% of patients. In this study, it is important to note that the lumbar region is predominantly affected with involvement in spinal region. CRP level was consistent with the number of organ involvements and was one of the most critical results of this study.

Demographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey.

Fournier's gangrene is an aggressive, rapidly progressing, and life-threatening necrotizing fasciitis of the perineal and genital regions. Various scoring systems have been developed for predicting survival and prognosis in Fournier's gangrene. This retrospective study aimed to evaluate the effectiveness of the newly developed Fournier's gangrene mortality index (FGMI) in predicting mortality associated with Fournier's gangrene.

Fournier's Gangrene Mortality Index (FGMI): A New Scoring System for Predicting Fournier's Gangrene Mortality.

In this multicenter, retrospective study involving 62 patients, we investigated whether switching from entecavir (ETV) or tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) represents a superior treatment strategy for patients with chronic hepatitis B (CHB) experiencing low-level viremia (LLV). The study determined that TAF significantly improved both virological and biochemical outcomes. At 48 weeks, the complete virological response (CVR) rate was 77.8% for those who switched from ETV and 81.8% for those who switched from TDF, with Hepatitis B virus deoxyribonucleic acid (HBV DNA) negativity reaching 81% by month 12. Additionally, significant normalization of liver enzymes, albumin, and platelet counts was observed across the cohort. While the switch from TDF was associated with a significant increase in triglycerides and high-density lipoprotein (HDL) and a decrease in estimated glomerular filtration rate (eGFR), no such changes were detected in the ETV group. This evidence suggests that TAF provides robust virological control in LLV patients and is associated with favorable biochemical improvements. However, due to the study's limitations, the strong assertion that TAF promotes the regression of liver fibrosis and reduces the risk of hepatocellular carcinoma (HCC) must be interpreted with caution.

Evaluation of the Efficacy of Tenofovir Alafenamide in Patients with Low-Level Viremia Under Chronic Hepatitis B Treatment.

Mucormycosis is a rapidly progressive angioinvasive fungal infection with limited large-scale outcome data. We aimed to describe the epidemiology, clinical spectrum, treatment strategies, and predictors of outcomes in adult patients with proven mucormycosis in Türkiye.

Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024).

 Potential drug-drug interaction (pDDI) refers to the co-administration of two or more drugs that interact with each other and may have therapeutic effects. Increasing rates of polypharmacy with age increase the risk of pDDIs in geriatric patients. This multicenter study aims to provide real-world data on the incidence of pDDI associated with antimicrobial therapy in hospitalized older adults.  The study screened all hospitalized patients, including those aged 65 years and older. Using the Lexicomp Drug Interaction Online Database, researchers screened for pDDIs among all medications taken by patients.  663 (24.0%) aged 65 and over were included in the study. Polypharmacy was present in 64.9%, and hyperpolypharmacy was present in 10.0% of the cases. 480 (72.4%) of the cases used antimicrobial therapy. The mean total number of drugs and antimicrobials used per case was 5.86 and 1.02, respectively. A total of 372 antimicrobial-related pDDIs were detected, and at least one antimicrobial-related pDDI was identified in 202 (42%) patients receiving antimicrobials. Ciprofloxacin (73.3%), clarithromycin (58.3%), and colistin (26.3%) had the highest numbers of D-type pDDIs. The antimicrobials with the highest incidence of X-type pDDIs were metronidazole (23.6%) and clarithromycin (8.3%), respectively. The logistic analysis found a significant association between antimicrobial-related pDDIs and an increase in the number of drugs, length of hospital stays, and ID departments.  PDDI rates associated with antimicrobials, like the high pDDI rates associated with all drugs, support the literature. Therefore, strategies should be developed to reduce the risk of pDDI when prescribing antimicrobials to geriatric patients.

Point-Prevalence of Antimicrobial-Related Potential Drug-Drug Interactions in Hospitalized Older Adults: A Multicenter Study Using Lexicomp.

The aim of the study was to evaluate inflammatory markers after 1 year of antiretroviral therapies use in persons living with human immunodeficiency virus.

Article	Year
Testicular involvement of Brucellosis: A 10-year, multicentre study. Journal of infection in developing countries\| PubMed ID: 37824350	2023
Investigation of hematologic findings related to brucellosis in Anatolian region. Saudi medical journal\| PubMed ID: 38734423	2024
Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B. Croatian medical journal\| PubMed ID: 39219194	2024
Predictive Significance of Laboratory Tests in Bacteremic Brucellosis. Iranian journal of public health\| PubMed ID: 39444471	2024
Demographic, clinical and laboratory characteristics of extrapulmonary tuberculosis: Eight-year results of a multicenter retrospective study in Turkey. Journal of investigative medicine : the official publication of the American Federation for Clinical Research\| PubMed ID: 39508290	2025
Fournier's Gangrene Mortality Index (FGMI): A New Scoring System for Predicting Fournier's Gangrene Mortality. Diagnostics (Basel, Switzerland)\| PubMed ID: 39682646	2024
Evaluation of the Efficacy of Tenofovir Alafenamide in Patients with Low-Level Viremia Under Chronic Hepatitis B Treatment. Viruses\| PubMed ID: 41305493	2025
Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004-2024). European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology\| PubMed ID: 41575678	2026
Point-Prevalence of Antimicrobial-Related Potential Drug-Drug Interactions in Hospitalized Older Adults: A Multicenter Study Using Lexicomp. Journal of clinical medicine\| PubMed ID: 41682845	2026
Evaluation of multi-inflammatory ındexes in persons living with human immunodeficiency virus: a multicenter study. Revista da Associacao Medica Brasileira (1992)\| PubMed ID: 41919878	2026

Mehmet Celik

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