Jonathan Chernoff

Fox Chase Cancer Center

Affiliated withFox Chase Cancer Center Fox Chase Cancer Center

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 332	2013
Publication title	2018

Other Publications

Article	Year
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Molecular and cellular biology\| PubMed ID: 9418872	1998
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. The Journal of cell biology\| PubMed ID: 10330410	1999
Regulation of macropinocytosis by p21-activated kinase-1. Molecular biology of the cell\| PubMed ID: 11029040	2000
Lentivirus Nef specifically activates Pak2. Journal of virology\| PubMed ID: 11070003	2000
Temporal and spatial distribution of activated Pak1 in fibroblasts. The Journal of cell biology\| PubMed ID: 11134074	2000
p21-activated kinase links Rac/Cdc42 signaling to merlin. The Journal of biological chemistry\| PubMed ID: 11719502	2002
The evolutionary history of effectors downstream of Cdc42 and Rac. Genome biology\| PubMed ID: 11864373	2002
p21-activated kinases: three more join the Pak. The international journal of biochemistry & cell biology\| PubMed ID: 11950587	2002
Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. The Biochemical journal\| PubMed ID: 12023880	2002
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO reports\| PubMed ID: 12151336	2002
Cell cycle-regulated phosphorylation of p21-activated kinase 1. Current biology : CB\| PubMed ID: 12176333	2002
Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome research\| PubMed ID: 12421766	2002
High midsummer for small GTPases. Trends in cell biology\| PubMed ID: 12446103	2002
Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene\| PubMed ID: 12466966	2002
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron\| PubMed ID: 12546821	2003
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell\| PubMed ID: 12757711	2003
p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Molecular biology of the cell\| PubMed ID: 12802076	2003
p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Molecular and cellular biology\| PubMed ID: 12897128	2003
Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. The Journal of biological chemistry\| PubMed ID: 12902327	2003
Pak1 and PIX regulate contact inhibition during epithelial wound healing. The EMBO journal\| PubMed ID: 12912914	2003
NF2: the wizardry of merlin. Genes, chromosomes & cancer\| PubMed ID: 14566860	2003
AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer research\| PubMed ID: 14583477	2003
P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and Î²-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology\| PubMed ID: 23183186	2013
Protein-tyrosine phosphatase 1B as a potential drug target for obesity. Current drug targets. Immune, endocrine and metabolic disorders\| PubMed ID: 14683461	2003
Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. The Journal of biological chemistry\| PubMed ID: 14764585	2004
Analysis and manipulation of intracellular signaling cascades. Methods (San Diego, Calif.)\| PubMed ID: 15003596	2004
The cross-Rho'ds of cell-cell adhesion. The Journal of biological chemistry\| PubMed ID: 15133033	2004
The genetics of Pak. Journal of cell science\| PubMed ID: 15331659	2004
Rho-GTPases: new members, new pathways. Journal of cellular biochemistry\| PubMed ID: 15543593	2005
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Molecular and cellular biology\| PubMed ID: 15713627	2005
Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene\| PubMed ID: 15735716	2005
Essential role of CIB1 in regulating PAK1 activation and cell migration. The Journal of cell biology\| PubMed ID: 16061695	2005
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. The Journal of biological chemistry\| PubMed ID: 16129686	2005
Pak GITs to Aurora-A. Developmental cell\| PubMed ID: 16256730	2005
Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (London, England : 1993)\| PubMed ID: 16271887	2005
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods (San Diego, Calif.)\| PubMed ID: 16288885	2005
Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Experimental cell research\| PubMed ID: 16289152	2005
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. The Journal of cell biology\| PubMed ID: 16492808	2006
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Molecular and cellular biology\| PubMed ID: 16581795	2006
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. Journal of molecular biology\| PubMed ID: 16837009	2006
Src transforms in a Cool way. Nature cell biology\| PubMed ID: 16946737	2006
Regulation of protein tyrosine phosphatase 1B by sumoylation. Nature cell biology\| PubMed ID: 17159996	2007
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of biological chemistry\| PubMed ID: 17392278	2007
alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of cell science\| PubMed ID: 17911169	2007
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 18054038	2008
A tale of two Paks. Biology of the cell / under the auspices of the European Cell Biology Organization\| PubMed ID: 18199048	2008
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chemistry & biology\| PubMed ID: 18420139	2008
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood\| PubMed ID: 18768391	2008
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. Journal of cell science\| PubMed ID: 18940914	2008
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood\| PubMed ID: 19124833	2009
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Experimental neurology\| PubMed ID: 19409384	2009
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19435845	2009
Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer research\| PubMed ID: 19435911	2009
The DeMSTification of mammalian Ste20 kinases. Current biology : CB\| PubMed ID: 19467213	2009
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PloS one\| PubMed ID: 19557173	2009
Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis. The international journal of biochemistry & cell biology\| PubMed ID: 19747561	2010
An emerging role for p21-activated kinases (Paks) in viral infections. Trends in cell biology\| PubMed ID: 20071173	2010
PTP1B: a double agent in metabolism and oncogenesis. Trends in biochemical sciences\| PubMed ID: 20381358	2010
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. The Journal of cell biology\| PubMed ID: 20603326	2010
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes & cancer\| PubMed ID: 20672017	2010
A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene\| PubMed ID: 20711231	2010
LOV conquers (sm)All GTPases. F1000 biology reports\| PubMed ID: 20948805	2010
The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. BJU international\| PubMed ID: 21050361	2011
p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. PloS one\| PubMed ID: 21072183	2010
Getting smart about p21-activated kinases. Molecular and cellular biology\| PubMed ID: 21115726	2011
Back to the future: proceedings from the 2010 NF Conference. American journal of medical genetics. Part A\| PubMed ID: 21271647	2011
Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. The Journal of biological chemistry\| PubMed ID: 21317288	2011
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small GTPases\| PubMed ID: 21686266	2010
Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small GTPases\| PubMed ID: 21686277	2011
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. The Journal of cell biology\| PubMed ID: 21708980	2011
Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. The EMBO journal\| PubMed ID: 21725281	2011
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental cell\| PubMed ID: 21924960	2011
Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. The Journal of biological chemistry\| PubMed ID: 21969371	2011
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. Journal of molecular and cellular cardiology\| PubMed ID: 21971074	2011
p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22037191	2012
Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. Journal of cell science\| PubMed ID: 22266903	2012
PKM2 enters the morpheein academy. Molecular cell\| PubMed ID: 22405271	2012
Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Molecular cancer research : MCR\| PubMed ID: 22798428	2012
Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. PloS one\| PubMed ID: 22900031	2012
p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer research\| PubMed ID: 22983922	2012
Mouse models of PAK function. Cellular logistics\| PubMed ID: 23162740	2012
Pak2 kinase restrains mast cell FcÎµRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. The Journal of biological chemistry\| PubMed ID: 23204526	2013
P-21-Activated Kinase 1 Mediates Gastrin-Stimulated Proliferation in the Colorectal Mucosa via Multiple Signalling Pathways. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23306081	2013
The Rac GTPase effector p21 activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood\| PubMed ID: 23335370	2013
The Tumor Suppressor Mst1 Promotes Changes in the Cellular Redox State by Phosphorylation and Inactivation of Peroxiredoxin-1. The Journal of biological chemistry\| PubMed ID: 23386615	2013
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer research\| PubMed ID: 23576562	2013
p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23640496	2013
Role of p21-activated kinases in cardiovascular development and function. Cellular and molecular life sciences : CMLS\| PubMed ID: 23640572	2013
ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. The Journal of biological chemistry\| PubMed ID: 23760270	2013
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. American journal of physiology. Cell physiology\| PubMed ID: 23784547	2013
Targeting Cdc42 in cancer. Expert opinion on therapeutic targets\| PubMed ID: 23957315	2013
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. The Journal of biological chemistry\| PubMed ID: 23960073	2013
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PloS one\| PubMed ID: 24019894	2013
Analysis of PTP1B sumoylation. Methods (San Diego, Calif.)\| PubMed ID: 24076082	2014
PAK signalling during the development and progression of cancer. Nature reviews. Cancer\| PubMed ID: 24505617	2014
Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology\| PubMed ID: 24684301	2014
A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Developmental cell\| PubMed ID: 24823378	2014
Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. eLife\| PubMed ID: 24843022	2014
p21-activated kinase inhibitors. The Enzymes\| PubMed ID: 25034104	2013
Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25225063	2014
Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood\| PubMed ID: 25331114	2015
Molecular pathways: targeting the kinase effectors of RHO-family GTPases. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25336694	2015
Potential compensation among group I PAK members in hindlimb ischemia and wound healing. PloS one\| PubMed ID: 25379771	2014
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem cells (Dayton, Ohio)\| PubMed ID: 25586960	2015
Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget\| PubMed ID: 25596744	2015
Regulation of mammalian Ste20 (Mst) kinases. Trends in biochemical sciences\| PubMed ID: 25665457	2015
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood\| PubMed ID: 25824689	2015
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast cancer research : BCR\| PubMed ID: 25902869	2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nature communications\| PubMed ID: 26104863	2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26157175	2015
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood\| PubMed ID: 26170031	2015
Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene\| PubMed ID: 26257058	2016
p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway. Molecular and cellular biology\| PubMed ID: 26391956	2015
p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood\| PubMed ID: 26932803	2016
H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization. Current biology : CB\| PubMed ID: 27238285	2016
The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. Small GTPases\| PubMed ID: 27427770	2017
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. Cell reports\| PubMed ID: 27452461	2016
Hras helps hippo heterodimerize to evade tumor suppression. Small GTPases\| PubMed ID: 27560370	2018
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. PLoS genetics\| PubMed ID: 27583434	2016
Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. Oncotarget\| PubMed ID: 27740936	2016
Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro. Molecular and cellular biology\| PubMed ID: 27920252	2017
Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type 1. Biochimie\| PubMed ID: 28065690	2017
Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016). Cancer research\| PubMed ID: 28202462	2017
Targeting PAK1. Biochemical Society transactions\| PubMed ID: 28202661	2017
Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis. Oncogene\| PubMed ID: 28534510	2017
Recent advances in methods to assess the activity of the kinome. F1000Research\| PubMed ID: 28713564	2017
An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis. Cancer research\| PubMed ID: 28729415	2017
Targeting MYC sensitizes malignant mesothelioma cells to PAK blockage-induced cytotoxicity. American journal of cancer research\| PubMed ID: 28861328	2017
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature\| PubMed ID: 28953887	2017
Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. Journal of molecular cell biology\| PubMed ID: 28992163	2017
Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors. Oncogene\| PubMed ID: 29059171	2018
Pak2 regulates myeloid-derived suppressor cell development in mice. Blood advances\| PubMed ID: 29296839	2017
PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer discovery\| PubMed ID: 29572236	2018
A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis. Oncoscience\| PubMed ID: 30035161	2018
Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nature communications\| PubMed ID: 30150766	2018
How to get and keep your lab funded. Molecular biology of the cell\| PubMed ID: 30325287	2018