solid-state-graft-copolymer-electrolytes-for-lithium-battery

Solid-state Graft Copolymer Electrolytes for Lithium Battery Applications

Battery safety has been a very important research area over the past decade. Commercially available lithium ion batteries employ low flash point (&lt;80 ...

Massachusetts Institute of Technology

The inhibitory effect of 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) on the proliferation of a number of human and rat liver cancer cell lines has recently been reported. In this study we have demonstrated that these cell lines express functional receptors able to specifically bind [3H]1,25-(OH)(2)D(3). The highest level of functional receptor were found in the human liver cancer cell line HepG2 which had previously been shown to be the most sensitive in 1,25-(OH)(2)D(3) growth inhibition assays. The identity of the binding protein with the Vitamin D3 receptor was confirmed by PCR analysis of HepG2 cell mRNA. Additionally, the inhibitory effect of 1,25-(OH)(2)D(3) on growth of the human liver cancer cell line HepG2 resulted from arrest in the G0/G1 phase of the cell cycle. Increases in the fraction of cells in G0/G1 were dependent upon the concentration of 1,25-(OH)(2)D(3) and were accompanied by complementary decreases in the number of cells in S phase. There was no change in the number of cells in G2+M at any concentration of the hormone. Clonal growth of HepG2 cells in response to 1,25-(OH)(2)D(3) was also dose dependent over three orders of magnitude, thus indicating heterogeneity in cell cycle arrest by this hormone.

1,25-Dihydroxyvitamin D(3) induced cell cycle arrest in the human primary liver cancer cell line HepG2.

A randomized Phase II study evaluated the activity of weekly paclitaxel versus its combination with trastuzumab for treatment of patients with advanced breast cancer overexpressing HER-2.

Randomized Phase II Trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer.

Article	Year
1,25-Dihydroxyvitamin D(3) induced cell cycle arrest in the human primary liver cancer cell line HepG2. Hepatology research : the official journal of the Japan Society of Hepatology\| PubMed ID: 12787802	2003
Randomized Phase II Trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer. Breast cancer research and treatment\| PubMed ID: 16850247	2007

Antonio Caputo

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