David Beebe

Department of Biomedical Engineering, University of Wisconsin-Madison

Affiliated withUniversity of Wisconsin-Madison

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2009

Other Publications

Article	Year
The function of FGF signaling in the lens placode. Developmental biology\| PubMed ID: 21223962	2011
Syndecan-1 in breast cancer stroma fibroblasts regulates extracellular matrix fiber organization and carcinoma cell motility. The American journal of pathology\| PubMed ID: 21224069	2011
Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Analytical chemistry\| PubMed ID: 21261280	2011
1-((3S,4S)-4-amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters\| PubMed ID: 21324688	2011
Vitreoretinal influences on lens function and cataract. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 21402587	2011
One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST). Lab on a chip\| PubMed ID: 21423999	2011
The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Disease models & mechanisms\| PubMed ID: 21504908	2011
Hax1 regulates neutrophil adhesion and motility through RhoA. The Journal of cell biology\| PubMed ID: 21518791	2011
Pipette-friendly laminar flow patterning for cell-based assays. Lab on a chip\| PubMed ID: 21523269	2011
The mechanism of lens placode formation: a case of matrix-mediated morphogenesis. Developmental biology\| PubMed ID: 21540023	2011
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends in biotechnology\| PubMed ID: 21549437	2011
Automation of three-dimensional cell culture in arrayed microfluidic devices. Journal of laboratory automation\| PubMed ID: 21609700	2011
Racial differences in ocular oxidative metabolism: implications for ocular disease. Archives of ophthalmology\| PubMed ID: 21746975	2011
Purification of cell subpopulations via immiscible filtration assisted by surface tension (IFAST). Biomedical microdevices\| PubMed ID: 21796389	2011
Anesthetic complications including two cases of postoperative respiratory depression in living liver donor surgery. Journal of anaesthesiology, clinical pharmacology\| PubMed ID: 21897509	2011
Quantification of kinase activity in cell lysates via photopatterned macroporous poly(ethylene glycol) hydrogel arrays in microfluidic channels. Biomedical microdevices\| PubMed ID: 22069079	2011
Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 22234342	2012
Microscale functional cytomics for studying hematologic cancers. Blood\| PubMed ID: 22262772	2012
Engineers are from PDMS-land, Biologists are from Polystyrenia. Lab on a chip\| PubMed ID: 22318426	2012
Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. Journal of medicinal chemistry\| PubMed ID: 11784155	2002
The effect of insufflation pressure on CO(2) pneumoperitoneum and embolism in piglets. Anesthesia and analgesia\| PubMed ID: 11973186	2002
Control and applications of immiscible liquids in microchannels. Journal of the American Chemical Society\| PubMed ID: 11996566	2002
Comparison of static and dynamic medium environments for culturing of pre-implantation mouse embryos. Comparative medicine\| PubMed ID: 12022391	2002
SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorganic & medicinal chemistry letters\| PubMed ID: 12031323	2002
Physics and applications of microfluidics in biology. Annual review of biomedical engineering\| PubMed ID: 12117759	2002
Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation. Development (Cambridge, England)\| PubMed ID: 12135918	2002
Principles of surface-directed liquid flow in microfluidic channels. Analytical chemistry\| PubMed ID: 12199600	2002
A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]... Journal of medicinal chemistry\| PubMed ID: 12238919	2002
Characterization of a silicon-based shear-force sensor on human subjects. IEEE transactions on bio-medical engineering\| PubMed ID: 12450364	2002
Evaluation of fibroblast growth factor signaling during lens fiber cell differentiation. Investigative ophthalmology & visual science\| PubMed ID: 12556399	2003
A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridaz... Journal of medicinal chemistry\| PubMed ID: 12773033	2003
Vascular endothelial growth factor expression and signaling in the lens. Investigative ophthalmology & visual science\| PubMed ID: 12939309	2003
Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5... Bioorganic & medicinal chemistry\| PubMed ID: 12951149	2003
X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase. Structure (London, England : 1993)\| PubMed ID: 12962626	2003
Organic and biomimetic designs for microfluidic systems. Analytical chemistry\| PubMed ID: 12964732	2003
Importance of vitreous liquefaction in age-related cataract. Investigative ophthalmology & visual science\| PubMed ID: 14691157	2004
Flow control with hydrogels. Advanced drug delivery reviews\| PubMed ID: 14741116	2004
Developments in in vitro technologies for swine embryo production. Reproduction, fertility, and development\| PubMed ID: 14972099	2004
Microfluidic removal of cumulus cells from Mammalian zygotes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15041774	2004
Mammalian embryo culture in a microfluidic device. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 15041775	2004
Microenvironment design considerations for cellular scale studies. Lab on a chip\| PubMed ID: 15052346	2004
The expression pattern of opticin during chicken embryogenesis. Gene expression patterns : GEP\| PubMed ID: 15053984	2004
Microfluidic valve with cored glass microneedle for microinjection. Lab on a chip\| PubMed ID: 15100768	2003
In situ fabricated porous filters for microsystems. Lab on a chip\| PubMed ID: 15100783	2003
A passive pumping method for microfluidic devices. Lab on a chip\| PubMed ID: 15100822	2002
An evaporation-based microfluidic sample concentration method. Lab on a chip\| PubMed ID: 15100834	2002
A hydrogel readout for autonomous detection of ions in microchannels. Lab on a chip\| PubMed ID: 15100838	2002
Ultra rapid prototyping of microfluidic systems using liquid phase photopolymerization. Lab on a chip\| PubMed ID: 15100862	2002
Embryonic development in the mouse is enhanced via microchannel culture. Lab on a chip\| PubMed ID: 15159776	2004
Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis\| PubMed ID: 15188260	2004
An externally driven magnetic microstirrer. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences\| PubMed ID: 15306484	2004
Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 15452068	2004
Contributions by members of the TGFbeta superfamily to lens development. The International journal of developmental biology\| PubMed ID: 15558476	2004
Hydrodynamic microfabrication via"on the fly" photopolymerization of microscale fibers and tubes. Lab on a chip\| PubMed ID: 15570368	2004
Magnetically-driven biomimetic micro pumping using vortices. Lab on a chip\| PubMed ID: 15570371	2004
Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. American journal of ophthalmology\| PubMed ID: 15733992	2005
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15778993	2005
Lead exposure and cataract risk in men. JAMA : the journal of the American Medical Association\| PubMed ID: 15827306	2005
Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15835930	2005
Patients want an anesthesiologist to plan and be in charge of their anesthesia. Journal of clinical anesthesia\| PubMed ID: 16102695	2005
Development of a disposable infusion system for the delivery of protein therapeutics. Biomedical microdevices\| PubMed ID: 16133810	2005
Diffusion dependent cell behavior in microenvironments. Lab on a chip\| PubMed ID: 16175265	2005
A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-... Journal of medicinal chemistry\| PubMed ID: 16190759	2005
Controlled microfluidic interfaces. Nature\| PubMed ID: 16193039	2005
Reduction of polyspermic penetration using biomimetic microfluidic technology during in vitro fertilization. Lab on a chip\| PubMed ID: 16234945	2005
Application of sexed semen technology to in vitro embryo production in cattle. Theriogenology\| PubMed ID: 16263159	2006
Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab on a chip\| PubMed ID: 16511622	2006
An oral tactile interface for blind navigation. IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society\| PubMed ID: 16562639	2006
Oxygen distribution in the rabbit eye and oxygen consumption by the lens. Investigative ophthalmology & visual science\| PubMed ID: 16565394	2006
Steady flow generation in microcirculatory systems. Lab on a chip\| PubMed ID: 16572221	2006
Capillary inserts in microcirculatory systems. Lab on a chip\| PubMed ID: 16572222	2006
A method for dynamic system characterization using hydraulic series resistance. Lab on a chip\| PubMed ID: 16652179	2006
Mammary stem and progenitor cells: tumour precursors? European journal of cancer (Oxford, England : 1990)\| PubMed ID: 16697180	2006
Lower intraocular oxygen tension in diabetic patients: possible contribution to decreased incidence of nuclear sclerotic cataract. American journal of ophthalmology\| PubMed ID: 16765670	2006
alpha-Smooth muscle actin is constitutively expressed in the lens epithelial cells of several species. Experimental eye research\| PubMed ID: 16769052	2006
Dissolvable membranes as sensing elements for microfluidics based biological/chemical sensors. Lab on a chip\| PubMed ID: 16804586	2006
Adaptive liquid microlenses activated by stimuli-responsive hydrogels. Nature\| PubMed ID: 16885981	2006
Do-it-yourself microelectrophoresis chips with integrated sample recovery. Electrophoresis\| PubMed ID: 16960842	2006
Public access success at PubMed. Science (New York, N.Y.)\| PubMed ID: 16973858	2006
Polarity effect in electrovibration for tactile display. IEEE transactions on bio-medical engineering\| PubMed ID: 17019869	2006
PDMS absorption of small molecules and consequences in microfluidic applications. Lab on a chip\| PubMed ID: 17203151	2006
PDMS bonding by means of a portable, low-cost corona system. Lab on a chip\| PubMed ID: 17203160	2006
Hydrogel-based reconfigurable components for microfluidic devices. Lab on a chip\| PubMed ID: 17268621	2007
Hybrid polymer/thin film impedance system for label free monitoring of cells. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 17270796	2004
Identification and expression of Hop, an atypical homeobox gene expressed late in lens fiber cell terminal differentiation. Molecular vision\| PubMed ID: 17277742	2007
Autonomously-triggered microfluidic cooling using thermo-responsive hydrogels. Lab on a chip\| PubMed ID: 17330161	2007
High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab on a chip\| PubMed ID: 17330162	2007
A plate reader-compatible microchannel array for cell biology assays. Lab on a chip\| PubMed ID: 17330172	2007
Comment on: the Stokes-Einstein equation and the physiological effects of vitreous surgery. Acta ophthalmologica Scandinavica\| PubMed ID: 17362364	2007
Spatiotemporal micropatterning of cells on arbitrary substrates. Analytical chemistry\| PubMed ID: 17465529	2007
Lectin-modified microchannels for mammalian cell capture and purification. Biomedical microdevices\| PubMed ID: 17516171	2007
Understanding microchannel culture: parameters involved in soluble factor signaling. Lab on a chip\| PubMed ID: 17538714	2007
Microfluidic based platform for characterization of protein interactions in hydrogel nanoenvironments. Analytical chemistry\| PubMed ID: 17569500	2007
Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo. BMC cell biology\| PubMed ID: 17592637	2007
Protocol for the fabrication of enzymatically crosslinked gelatin microchannels for microfluidic cell culture. Nature protocols\| PubMed ID: 17641645	2007
Anaesthetic management of patients with congenital heart disease presenting for non-cardiac surgery. Annals of cardiac anaesthesia\| PubMed ID: 17890798	2002
Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues. Seminars in cell & developmental biology\| PubMed ID: 17920963	2008
Microfluidic logic gates and timers. Lab on a chip\| PubMed ID: 17960270	2007
Flow rate analysis of a surface tension driven passive micropump. Lab on a chip\| PubMed ID: 17960274	2007
Microscale bioengineering inspired by nature: from widgets to cell biology. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference\| PubMed ID: 18001872	2007
Age-dependent control of lens growth by hypoxia. Investigative ophthalmology & visual science\| PubMed ID: 18326726	2008
Automated cell culture in high density tubeless microfluidic device arrays. Lab on a chip\| PubMed ID: 18432341	2008
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Developmental biology\| PubMed ID: 18455718	2008
Myopia and axial length contribute to vitreous liquefaction and nuclear cataract. Archives of ophthalmology\| PubMed ID: 18474803	2008
An adaptable hydrogel array format for 3-dimensional cell culture and analysis. Biomaterials\| PubMed ID: 18486205	2008
Managing evaporation for more robust microscale assays. Part 1. Volume loss in high throughput assays. Lab on a chip\| PubMed ID: 18497901	2008
Managing evaporation for more robust microscale assays. Part 2. Characterization of convection and diffusion for cell biology. Lab on a chip\| PubMed ID: 18497902	2008
Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Investigative ophthalmology & visual science\| PubMed ID: 18566469	2008
HIF-1: an age-dependent regulator of lens cell proliferation. Investigative ophthalmology & visual science\| PubMed ID: 18586877	2008
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development (Cambridge, England)\| PubMed ID: 18653562	2008
Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 18693260	2008
Quantification of small cell numbers with a microchannel device. BioTechniques\| PubMed ID: 18778256	2008
The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts. Experimental eye research\| PubMed ID: 18782574	2009
A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab on a chip\| PubMed ID: 18818806	2008
Bead-based microfluidic toxin sensor integrating evaporative signal amplification. Lab on a chip\| PubMed ID: 18941677	2008
Biomimetic soft multifunctional miniature aquabots. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18989854	2008
Infection on a chip: a microscale platform for simple and sensitive cell-based virus assays. Biomedical microdevices\| PubMed ID: 19142734	2009
Failure rates and survival analysis of maxillary expansion appliances: a 24-year retrospective analysis. Pediatric dentistry\| PubMed ID: 19186771	2008
Cell-free protein expression in a microchannel array with passive pumping. Lab on a chip\| PubMed ID: 19209336	2009
Self-assembled peptide monolayers as a toxin sensing mechanism within arrayed microchannels. Analytical chemistry\| PubMed ID: 19253949	2009
Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes. Bioorganic & medicinal chemistry letters\| PubMed ID: 19285862	2009
The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts. Archives of ophthalmology\| PubMed ID: 19365028	2009
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (Cambridge, England)\| PubMed ID: 19369394	2009
Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PloS one\| PubMed ID: 19412548	2009
An accessible micro-capillary electrophoresis device using surface-tension-driven flow. Electrophoresis\| PubMed ID: 19425002	2009
Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle. Bioorganic & medicinal chemistry letters\| PubMed ID: 19435665	2009
Selective and tunable gradient device for cell culture and chemotaxis study. Lab on a chip\| PubMed ID: 19495465	2009
Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices. Biomaterials\| PubMed ID: 19540580	2009
Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. The Journal of biological chemistry\| PubMed ID: 19553668	2009
Biological implications of polydimethylsiloxane-based microfluidic cell culture. Lab on a chip\| PubMed ID: 19606288	2009
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Developmental biology\| PubMed ID: 19733164	2009
Cellular observations enabled by microculture: paracrine signaling and population demographics. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20011455	2009
Introducing a new Method section for Integrative Biology. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023753	2009
Integrating biology and technology. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023786	2009
The development of integrative biology: bridging the gap--a view from the Scientific Editors. [An interview with David Beebe and Mary Helen Barcellos-Hoff by Kathleen Too]. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023799	2009
From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023802	2009
Fundamentals of microfluidic cell culture in controlled microenvironments. Chemical Society reviews\| PubMed ID: 20179823	2010
The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens. Investigative ophthalmology & visual science\| PubMed ID: 20181838	2010
Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization. JALA (Charlottesville, Va.)\| PubMed ID: 20209121	2010
Counterpoint: The lens fluid circulation model--a critical appraisal. Investigative ophthalmology & visual science\| PubMed ID: 20435605	2010
3D microchannel co-culture: method and biological validation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20577680	2010
A Cell Programmable Assay (CPA) chip. Lab on a chip\| PubMed ID: 20614082	2010
Cell culture models in microfluidic systems. Annual review of analytical chemistry (Palo Alto, Calif.)\| PubMed ID: 20636085	2008
Synaptotagmin II peptide-bead conjugate for botulinum toxin enrichment and detection in microchannels. Biosensors & bioelectronics\| PubMed ID: 20650627	2011
Expanding the available assays: adapting and validating In-Cell Westerns in microfluidic devices for cell-based assays. Assay and drug development technologies\| PubMed ID: 20658945	2010
Visualizing lens epithelial cell proliferation in whole lenses. Molecular vision\| PubMed ID: 20664699	2010
Ischemic diabetic retinopathy may protect against nuclear sclerotic cataract. American journal of ophthalmology\| PubMed ID: 20688316	2010
Oxygen distribution in the human eye: relevance to the etiology of open-angle glaucoma after vitrectomy. Investigative ophthalmology & visual science\| PubMed ID: 20720218	2010
Oxidative damage and the prevention of age-related cataracts. Ophthalmic research\| PubMed ID: 20829639	2010
A microfluidic cell concentrator. Analytical chemistry\| PubMed ID: 20843010	2010
Comparison of two probe designs for determining intraocular oxygen distribution. The British journal of ophthalmology\| PubMed ID: 20870641	2011
An arrayed high-content chemotaxis assay for patient diagnosis. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20953490	2010
Introduction to the mechanisms of directed cell migration themed issue. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20957298	2010
Development of macroporous poly(ethylene glycol) hydrogel arrays within microfluidic channels. Biomacromolecules\| PubMed ID: 21028794	2010
Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels. Journal of biomolecular screening\| PubMed ID: 21131594	2011
Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 21135965	2011