assessing-association-between-age-at-first-sexual-intercourse-hiv

Assessing the Association Between Age at First Sexual Intercourse and HIV Infection Risk Using A Two-sample Mendelian Randomization Framework

This study applied a two-sample Mendelian randomization framework to investigate the potential association between age at first sexual intercourse (AFS) ...

The First Affiliated Hospital, Zhejiang University School of Medicine

Treatment adherence among people living with human immunodeficiency virus (PLWH) is a critical determinant of viral suppression and improved quality of life. Medication literacy, as a key factor influencing adherence, is itself shaped by various psychosocial variables. Existing studies suggest that human immunodeficiency virus (HIV)-related stigma, self-efficacy, and trust in healthcare providers serve as significant mediators in the relationship between health literacy and treatment adherence. This review systematically explores how medication literacy affects treatment adherence in PLWH through intermediary psychosocial mechanisms such as depression, anxiety, and social support. By synthesizing current evidence, we aim to inform the development of targeted psychosocial interventions to enhance treatment outcomes and quality of life for this population. Our findings provide an evidence-based foundation for nursing practice and support innovative strategies in comprehensive HIV care.

Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors.

Acute myeloid leukemia (AML), the most common acute leukemia among adults, poses significant therapeutic challenges due to diagnostic limitations and the frequent development of treatment resistance. While genomics-based approaches have advanced, DNA aberrations do not always reflect the expression levels of genes and proteins, which are more tightly connected to disease phenotypes. Recently, the role of the gut microbiota in AML has gained increasing attention. AML patients often exhibit gut microbiota dysbiosis, which is linked to disease progression and heightened infection risk. Mounting evidence indicates that gut microbiota metabolism influences hematopoiesis and immune function via the "gut-bone marrow axis," with microbiota composition and diversity significantly affecting treatment outcomes and prognosis. High-throughput sequencing and metabolomics have identified correlations between gut microbiota composition and its metabolic products with AML clinical characteristics, paving the way for new biomarkers in diagnosis and prognosis. Additionally, treatments such as fecal microbiota transplantation (FMT) show promise in enhancing chemotherapy efficacy and improving patient outcomes. This review highlights recent advances in understanding the role of the gut microbiota in AML and explores new perspectives for its diagnosis and treatment.

Article	Year
Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors. World journal of psychiatry\| PubMed ID: 40837811	2025
Gut Microbiota in Acute Myeloid Leukemia: From Biomarkers to Interventions. Metabolites\| PubMed ID: 41002952	2025

Lewen Shao

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