caenorhabditis-elegans-versatile-vivo-model-for-decoding-conserved

<em>Caenorhabditis elegans</em>: A Versatile <em>In vivo</em> Model for Decoding Conserved Oncogenic Signaling Pathways

Caenorhabditis elegans (C. elegans) is a genetically tractable, transparent, and cost-effective metazoan model that bridges conventional cell-culture ...

The Second Affiliated Hospital of Jiaxing University

Development of myopia is associated with remodeling of the sclera, a tissue composed principally of collagen. Cyclic guanosine monophosphate (cGMP) regulates collagen synthesis in several organs; therefore, we investigated the effects of soluble guanylyl cyclase (sGC) stimulation and inhibition on refraction and ocular growth in guinea pigs under normal and form-deprived (FD) conditions.

The role of cGMP in ocular growth and the development of form-deprivation myopia in guinea pigs.

This study used dopamine D2 receptor (D2R) knockout (KO) mice to investigate the role of D2R activity in the development of form-deprivation myopia (FDM). Sulpiride, a D2R antagonist, was administered systemically into wild-type (WT) mice to validate the involvement of D2R in FDM development.

Activation of dopamine D2 receptor is critical for the development of form-deprivation myopia in the C57BL/6 mouse.

The purpose of this study was to explore the role and mechanism of D2 receptor (D2R) involvement in myopia development and the effects of the full D2R agonist quinpirole and partial D2R agonist aripiprazole on postnatal refractive development and form-deprivation myopia (FDM).

Article	Year
The role of cGMP in ocular growth and the development of form-deprivation myopia in guinea pigs. Investigative ophthalmology & visual science\| PubMed ID: 24130184	2013
Activation of dopamine D2 receptor is critical for the development of form-deprivation myopia in the C57BL/6 mouse. Investigative ophthalmology & visual science\| PubMed ID: 25097246	2014
The Role of the Dopamine D2 Receptor in Form-Deprivation Myopia in Mice: Studies With Full and Partial D2 Receptor Agonists and Knockouts. Investigative ophthalmology & visual science\| PubMed ID: 32572456	2020

Tingting Yan

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