Hermona Soreq

Department of Biological Chemistry and The Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem

Affiliated withThe Hebrew University of Jerusalem

Research Area

Behavior

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 23	2013

Other Publications

Article	Year
Runx1/AML1 in leukemia: disrupted association with diverse protein partners. Leukemia research\| PubMed ID: 11792409	2002
Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science (New York, N.Y.)\| PubMed ID: 11799248	2002
Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase. Journal of molecular neuroscience : MN\| PubMed ID: 12059039	2002
Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements. European journal of biochemistry / FEBS\| PubMed ID: 12153557	2002
The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation. Experimental hematology\| PubMed ID: 12384146	2002
Complex regulation of acetylcholinesterase gene expression in human brain tumors. Oncogene\| PubMed ID: 12466963	2002
Defects in pre-mRNA processing as causes of and predisposition to diseases. DNA and cell biology\| PubMed ID: 12489991	2002
Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology. The Journal of physiology\| PubMed ID: 12509486	2003
Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12509514	2003
The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12554700	2003
Ethics, public policy and behavioral genetics. The Israel Medical Association journal : IMAJ\| PubMed ID: 12674653	2003
Pre-mRNA splicing modulations in senescence. Aging cell\| PubMed ID: 12882348	2002
Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase. Journal of molecular neuroscience : MN\| PubMed ID: 14645987	2003
Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15060281	2004
Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products. The Journal of biological chemistry\| PubMed ID: 15123727	2004
CREB regulates AChE-R-induced proliferation of human glioblastoma cells. Neoplasia (New York, N.Y.)\| PubMed ID: 15153340	2004
Organophosphate risk of leukemogenesis. Leukemia research\| PubMed ID: 15234565	2004
From brain to blood: alternative splicing evidence for the cholinergic basis of Mammalian stress responses. Annals of the New York Academy of Sciences\| PubMed ID: 15240356	2004
Blood-cell-specific acetylcholinesterase splice variations under changing stimuli. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 15465282	2004
Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 15483114	2004
Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression. Bioinformatics (Oxford, England)\| PubMed ID: 15550480	2005
Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants. Plant molecular biology\| PubMed ID: 15604663	2004
Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15629887	2005
Function of alternative splicing. Gene\| PubMed ID: 15656968	2005
Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. Journal of neurochemistry\| PubMed ID: 15715671	2005
Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 15749986	2005
Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Annals of neurology\| PubMed ID: 15852394	2005
Chronic cholinergic imbalances promote brain diffusion and transport abnormalities. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15923401	2005
Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Current Alzheimer research\| PubMed ID: 15974894	2005
Cellular stress reactions as putative cholinergic links in Alzheimer's disease. Neurochemical research\| PubMed ID: 16187225	2005
MicroRNA modulation of megakaryoblast fate involves cholinergic signaling. Leukemia research\| PubMed ID: 16249029	2006
Purification of transgenic plant-derived recombinant human acetylcholinesterase-R. Chemico-biological interactions\| PubMed ID: 16269140	2005
Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16365392	2006
Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis. Blood\| PubMed ID: 16380450	2006
Characterizing pea acetylcholinesterase. Chemico-biological interactions\| PubMed ID: 16429548	2005
RACK1 has the nerve to act: structure meets function in the nervous system. Progress in neurobiology\| PubMed ID: 16457939	2006
Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends in neurosciences\| PubMed ID: 16516310	2006
Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants. Journal of neurochemistry\| PubMed ID: 16635247	2006
ARP, the cleavable C-terminal peptide of "readthrough" acetylcholinesterase, promotes neuronal development and plasticity. Journal of molecular neuroscience : MN\| PubMed ID: 16691012	2006
Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16731619	2006
Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research\| PubMed ID: 16802134	2006
Gene-environment interactions in sporadic Parkinson's disease. Journal of neurochemistry\| PubMed ID: 16805780	2006
Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16807370	2006
Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties. Biological psychiatry\| PubMed ID: 16904653	2006
RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neuro-degenerative diseases\| PubMed ID: 16908999	2005
Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults. Toxicology\| PubMed ID: 17005312	2007
Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression. Annals of the New York Academy of Sciences\| PubMed ID: 17145929	2006
Readthrough acetylcholinesterase: a multifaceted inducer of stress reactions. Journal of molecular neuroscience : MN\| PubMed ID: 17192675	2006
Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selection. The European journal of neuroscience\| PubMed ID: 17241270	2007
It is all about resolution. Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia). The FEBS journal\| PubMed ID: 17269934	2007
The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood\| PubMed ID: 17272501	2007
A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Investigative ophthalmology & visual science\| PubMed ID: 17325175	2007
Readthrough acetylcholinesterase in inflammation-associated neuropathies. Life sciences\| PubMed ID: 17379257	2007
Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17475919	2007
Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC biotechnology\| PubMed ID: 17537261	2007
Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling. Neuro-degenerative diseases\| PubMed ID: 17596712	2007
Cholinergic status modulations in human volunteers under acute inflammation. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 17657467	2007
Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory. Brain, behavior, and immunity\| PubMed ID: 17959355	2008
Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain : a journal of neurology\| PubMed ID: 18056160	2008
Acetylcholinesterase activity in veterans of the first Gulf War. Journal of investigative medicine : the official publication of the American Federation for Clinical Research\| PubMed ID: 18062897	2007
Introduction: cholinesterases, from molecular complexity to non-hydrolytic functions. The FEBS journal\| PubMed ID: 18205835	2008
The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice. Behavioural brain research\| PubMed ID: 18243359	2008
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. The European journal of neuroscience\| PubMed ID: 18333967	2008
The structural basis of amyloid formation. Current Alzheimer research\| PubMed ID: 18537539	2008
Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays. PloS one\| PubMed ID: 18545673	2008
Antisense treatment for myasthenia gravis: experience with monarsen. Annals of the New York Academy of Sciences\| PubMed ID: 18567879	2008
Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions. Chemico-biological interactions\| PubMed ID: 18572152	2008
Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients. Journal of neuroimmunology\| PubMed ID: 18692253	2008
N-acetylcholinesterase-induced apoptosis in Alzheimer's disease. PloS one\| PubMed ID: 18769671	2008
Stress-induced alternative splicing modulations in brain and periphery: acetylcholinesterase as a case study. Annals of the New York Academy of Sciences\| PubMed ID: 19120119	2008
A network-based method for predicting disease-causing genes. Journal of computational biology : a journal of computational molecular cell biology\| PubMed ID: 19193144	2009
Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. The Journal of biological chemistry\| PubMed ID: 19282290	2009
The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology. The Journal of biological chemistry\| PubMed ID: 19383604	2009
Pro-apoptotic protein-protein interactions of the extended N-AChE terminus. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 19533292	2009
Changes in brain MicroRNAs contribute to cholinergic stress reactions. Journal of molecular neuroscience : MN\| PubMed ID: 19711202	2010
Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain. Brain, behavior, and immunity\| PubMed ID: 19729061	2010
MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity\| PubMed ID: 20005135	2009
Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study. Chemico-biological interactions\| PubMed ID: 20060816	2010
Acetylcholinesterase variants in Alzheimer's disease: from neuroprotection to programmed cell death. Neuro-degenerative diseases\| PubMed ID: 20173328	2010
Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase. Plant biotechnology journal\| PubMed ID: 20353404	2010
Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 20464061	2010
Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiology of disease\| PubMed ID: 20600907	2010
Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. Journal of cellular and molecular medicine\| PubMed ID: 20807286	2011
Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21059932	2010
Cholinesterase modulations in patients with acute bacterial meningitis. Scandinavian journal of clinical and laboratory investigation\| PubMed ID: 21303225	2011
Effects of physostigmine on microcirculatory alterations during experimental endotoxemia. Shock (Augusta, Ga.)\| PubMed ID: 21499071	2011
Similar cation channels mediate protection from cerebellar exitotoxicity by exercise and inheritance. Journal of cellular and molecular medicine\| PubMed ID: 21507200	2012
NeurimmiRs: microRNAs in the neuroimmune interface. Trends in molecular medicine\| PubMed ID: 21813326	2011
Letter by Shenhar-Tsarfaty et al regarding article, "Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage". Stroke; a journal of cerebral circulation\| PubMed ID: 21868734	2011
Deep brain stimulation induces rapidly reversible transcript changes in Parkinson's leucocytes. Journal of cellular and molecular medicine\| PubMed ID: 21910823	2012
Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes. Frontiers in molecular neuroscience\| PubMed ID: 22007158	2011
Adaptive alternative splicing correlates with less environmental risk of parkinsonism. Neuro-degenerative diseases\| PubMed ID: 22042332	2012
Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol. International journal of stroke : official journal of the International Stroke Society\| PubMed ID: 22044517	2012
Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle. Biochimica et biophysica acta\| PubMed ID: 22093924	2012
Exon arrays reveal alternative splicing aberrations in Parkinson's disease leukocytes. Neuro-degenerative diseases\| PubMed ID: 22156489	2012
Activation of the alternative NFÎºB pathway improves disease symptoms in a model of Sjogren's syndrome. PloS one\| PubMed ID: 22174879	2011
Threshold-independent meta-analysis of Alzheimer's disease transcriptomes shows progressive changes in hippocampal functions, epigenetics and microRNA regulation. Current Alzheimer research\| PubMed ID: 22191566	2012
Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways. Neurobiology of disease\| PubMed ID: 22198569	2012
Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions. Frontiers in molecular neuroscience\| PubMed ID: 22448158	2012
Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice. EMBO molecular medicine\| PubMed ID: 22628224	2012
Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis. Frontiers in molecular neuroscience\| PubMed ID: 22639569	2012
Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling. Journal of cellular and molecular medicine\| PubMed ID: 22697296	2012
Quantum dot labeling of butyrylcholinesterase maintains substrate and inhibitor interactions and cell adherence features. ACS chemical neuroscience\| PubMed ID: 22778863	2011
Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia\| PubMed ID: 23134494	2012
Plasma acetylcholinesterase activity correlates with intracerebral Î²-amyloid load. Current Alzheimer research\| PubMed ID: 23157337	2013
Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23236169	2012
Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: From structural insights to post-transcriptional regulatory roles. Molecular and cellular neurosciences\| PubMed ID: 23247072	2012
Further developments with antisense treatment for myasthenia gravis. Annals of the New York Academy of Sciences\| PubMed ID: 23278572	2012
Acetylcholinesterase: old questions and new developments. Frontiers in molecular neuroscience\| PubMed ID: 23316131	2012
Statistically invalid classification of high throughput gene expression data. Scientific reports\| PubMed ID: 23346359	2013
MicroRNA-132 Modulates Cholinergic Signaling and Inflammation in Human Inflammatory Bowel Disease. Inflammatory bowel diseases\| PubMed ID: 23598815	2013
Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes. Frontiers in molecular neuroscience\| PubMed ID: 23717260	2013