Xiang Xue

Department of Molecular & Integrative Physiology, University of Michigan

Affiliated withUniversity of Michigan University of New Mexico

Research Area

Biography

Dr. Xue’s lab is focused on studying molecular mechanisms for inflammatory bowel disease (IBD) and colorectal cancer (CRC). He utilizes cell line and enteroid cultures, mouse models, patient tissues and a wide array of molecular and biochemical methodologies. Several ongoing projects in the lab include:

Why are micronutrients essential for cancer cell growth?

How does mitochondrial metabolism regulate the progress of cancer?

Whether stress activated pathways play a role in cancer cell metabolism?

What role does hypoxia signaling have in intestinal inflammation and colorectal cancer?

What is the critical link between nutrient homeostasis, inflammation and cancer?

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 44	2013
Publication title Cited by 302	2020

Other Publications

Article	Year
Hypoxia-inducible factor-2Î± activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer research\| PubMed ID: 22419665	2012
Two chiral coordination polymers: preparation and X-ray structures of mono(4-sulfo-L-phenylalanine)(diaqua) zinc(II) and copper(II) complexes. Inorganic chemistry\| PubMed ID: 12055012	2002
A cluster rearrangement of an open cubane (Cu4Br4) to a prismane (Cu6Br6) in a copper(I)-olefin network. Angewandte Chemie (International ed. in English)\| PubMed ID: 12203419	2002
Novel, acentric metal-organic coordination polymers from hydrothermal reactions involving in situ ligand synthesis. Angewandte Chemie (International ed. in English)\| PubMed ID: 12386852	2002
Hydrothermal preparation of novel Cd(II) coordination polymers employing 5-(4-pyridyl)tetrazolate as a bridging ligand. Inorganic chemistry\| PubMed ID: 12470047	2002
Differential gene expression in primary and recurrent carotid stenosis. Biochemical and biophysical research communications\| PubMed ID: 12615063	2003
Altered expression of vascular endothelial growth factor and its receptors in normal saphenous vein and in arterialized and stenotic vein grafts. American journal of surgery\| PubMed ID: 14599626	2003
[Effects of sowing times on the spike differentiation of different wheat varieties under the climate of warm winter]. Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban\| PubMed ID: 14986353	2003
Baicalin protects mouse from Concanavalin A-induced liver injury through inhibition of cytokine production and hepatocyte apoptosis. Liver international : official journal of the International Association for the Study of the Liver\| PubMed ID: 17403198	2007
Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid. Toxicology and applied pharmacology\| PubMed ID: 17521691	2007
Thermal cyclodehydrogenations to form 6-membered rings: cyclizations of [5]helicenes. Organic letters\| PubMed ID: 17760450	2007
Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock. Biochemical pharmacology\| PubMed ID: 18191816	2008
Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 18495746	2008
Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin. Toxicology\| PubMed ID: 18499325	2008
Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. Journal of ethnopharmacology\| PubMed ID: 18582552	2008
The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury. Toxicology letters\| PubMed ID: 19429231	2009
[Changes in the mRNA expressions of myocardial cytoskeletal proteins in endotoxemic rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 19726336	2009
beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism. Acta pharmacologica Sinica\| PubMed ID: 19890363	2009
[Role of Na(+)-K(+)-ATPase in lipopolysaccharide-induced cardiomyocyte hypertrophy in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 20855249	2010
Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 20855424	2010
[Progress of the study of mechanism on drug induced kidney injury]. Yao xue xue bao = Acta pharmaceutica Sinica\| PubMed ID: 21348296	2010
Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. The Journal of biological chemistry\| PubMed ID: 21498508	2011
Hypoxia-inducible transcription factor 2Î± promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. Hepatology (Baltimore, Md.)\| PubMed ID: 21538443	2011
[Determination of tracer gas contents in sediment pore water of gas hydrate area by two-dimensional gas chromatography]. Se pu = Chinese journal of chromatography / Zhongguo hua xue hui\| PubMed ID: 21574403	2011
Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity. Toxicology letters\| PubMed ID: 21596114	2011
Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 21613233	2011
Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I. Molecular pharmaceutics\| PubMed ID: 21980933	2011
Structural basis and kinetics of force-induced conformational changes of an Î±A domain-containing integrin. PloS one\| PubMed ID: 22140490	2011
Targeting of dicer-2 and RNA by a viral RNA silencing suppressor in Drosophila cells. Journal of virology\| PubMed ID: 22438534	2012
[Effects of somatostatin in a rabbit model of abdominal compartment syndrome induced by prolonged intra-abdominal hypertension]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 22445990	2012
The hypoxia-inducible factor-C/EBPÎ± axis controls ethanol-mediated hepcidin repression. Molecular and cellular biology\| PubMed ID: 22869521	2012
[Effects of abdominal compartment syndrome on circulation and respiratory function in rabbits]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University\| PubMed ID: 22985571	2012
Hypoxia-inducible factor-2Î± is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis\| PubMed ID: 23042097	2013
[Analysis of death characteristics and its potential mechanisms in rats with endotoxin- induced cardiomyopathy]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue\| PubMed ID: 23168204	2012
High Frequency of Putative Ovarian Cancer Stem Cells With CD44/CK19 Coexpression Is Associated With Decreased Progression-Free Intervals In Patients With Recurrent Epithelial Ovarian Cancer. Reproductive sciences (Thousand Oaks, Calif.)\| PubMed ID: 23171677	2013
Evaluation of risk factors for venous thromboembolism in Chinese women with epithelial ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society\| PubMed ID: 23196757	2013
Membrane association of Wuhan nodavirus protein A is required for its ability to accumulate genomic RNA1 template. Virology\| PubMed ID: 23490047	2013
Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca(2+) leak by reducing oxidative modification of ryanodine receptors. Free radical biology & medicine\| PubMed ID: 23499836	2013
The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth. Toxicology and applied pharmacology\| PubMed ID: 31054940	2019
The Role of Immune Cells and Cytokines in Intestinal Wound Healing. International journal of molecular sciences\| PubMed ID: 31816903	2019
Death from Covid-19 of 23 Health Care Workers in China. The New England journal of medicine\| PubMed ID: 32294342	2020
Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. Aging\| PubMed ID: 32320384	2020
Exposure time determines the protective effect of Trichinella spiralis on experimental colitis. Microbial pathogenesis\| PubMed ID: 32442663	2020