a-porcine-model-of-acute-autologous-pulmonary-embolism

A Porcine Model of Acute Autologous Pulmonary Embolism

Acute pulmonary embolism (PE) is a potentially life-threatening condition that causes abrupt obstruction of the pulmonary arteries, leading to acute right ...

Aarhus University Hospital

The haemodynamic response following acute, intermediate-risk pulmonary embolism is not well described. We aimed to describe the cardiovascular changes in the initial, critical phase 0-12 hours after acute pulmonary embolism in an in-vivo porcine model.

Right ventricular adaptation in the critical phase after acute intermediate-risk pulmonary embolism.

Inhaled nitric oxide (iNO) effectively reduces right ventricular afterload when administered in the immediate phase of acute pulmonary embolism (PE) in preclinical animal models. In a porcine model of intermediate-risk PE, we aimed to investigate whether iNO has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute PE.

Inhaled nitric oxide has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute pulmonary embolism.

The use of inferior vena cava (IVC) filters is controversial. However, the procedure is widely performed for secondary prophylaxis in patients with severe pulmonary embolism (PE), including those treated by a PE response team (PERT). In this study, we analyzed patient factors associated with the clinical decision to place an IVC filter in PERT patients.

Patient and operational factors that influence the decision to place an inferior vena cava filter in a pulmonary embolism response team.

To investigate if oxygen could unload the right ventricle and improve right ventricle function in a porcine model mimicking intermediate-high risk acute pulmonary embolism.

Article	Year
Right ventricular adaptation in the critical phase after acute intermediate-risk pulmonary embolism. European heart journal. Acute cardiovascular care\| PubMed ID: 32436719	2020
Inhaled nitric oxide has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute pulmonary embolism. European heart journal. Acute cardiovascular care\| PubMed ID: 32662283	2020
Patient and operational factors that influence the decision to place an inferior vena cava filter in a pulmonary embolism response team. Journal of vascular surgery. Venous and lymphatic disorders\| PubMed ID: 33278645	2020
Inhaled nitric oxide has pulmonary vasodilator efficacy both in the immediate and prolonged phase of acute pulmonary embolism. European heart journal. Acute cardiovascular care\| PubMed ID: 33609138	2020
Oxygen Therapy Lowers Right Ventricular Afterload in Experimental Acute Pulmonary Embolism. Critical care medicine\| PubMed ID: 33870917	2021

Christian Schmidt Mortensen

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