Vincent Poitout

Montreal Diabetes Research Center, CRCHUM

Affiliated withCRCHUM University of Montreal

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2013

Other Publications

Article	Year
Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity. Endocrinology\| PubMed ID: 11796484	2002
Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats. Diabetes\| PubMed ID: 11872664	2002
Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase. Endocrinology\| PubMed ID: 12193544	2002
Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol. Transplantation\| PubMed ID: 12451242	2002
Insulin secretory deficiency and glucose intolerance in Rab3A null mice. The Journal of biological chemistry\| PubMed ID: 12510060	2003
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. The Journal of biological chemistry\| PubMed ID: 12771145	2003
The ins and outs of fatty acids on the pancreatic beta cell. Trends in endocrinology and metabolism: TEM\| PubMed ID: 12826323	2003
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes\| PubMed ID: 14749276	2004
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes\| PubMed ID: 15047616	2004
Beta-cell lipotoxicity: burning fat into heat? Endocrinology\| PubMed ID: 15265823	2004
Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes\| PubMed ID: 15448091	2004
Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 15650027	2005
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. The Journal of biological chemistry\| PubMed ID: 15665000	2005
Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha). FEBS letters\| PubMed ID: 15848159	2005
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. The Journal of biological chemistry\| PubMed ID: 15944145	2005
Regulation of the insulin gene by glucose and fatty acids. The Journal of nutrition\| PubMed ID: 16549443	2006
Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS. Journal of proteome research\| PubMed ID: 17137336	2006
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes\| PubMed ID: 17395749	2007
G protein-coupled receptors and insulin secretion: 119 and counting. Endocrinology\| PubMed ID: 17507578	2007
Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17925452	2008
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes\| PubMed ID: 17991758	2008
Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocrine reviews\| PubMed ID: 18048763	2008
The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes\| PubMed ID: 18559658	2008
Glucolipotoxicity of the pancreatic beta-cell: myth or reality? Biochemical Society transactions\| PubMed ID: 18793158	2008
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. The Journal of biological chemistry\| PubMed ID: 19004825	2009
Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. The Journal of biological chemistry\| PubMed ID: 19389712	2009
GPR40: good cop, bad cop? Diabetes\| PubMed ID: 19401432	2009
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology\| PubMed ID: 19406947	2009
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes\| PubMed ID: 19502418	2009
Glucolipotoxicity of the pancreatic beta cell. Biochimica et biophysica acta\| PubMed ID: 19715772	2010
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes\| PubMed ID: 19720802	2009
Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes\| PubMed ID: 19875615	2010
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. The Clinical biochemist. Reviews / Australian Association of Clinical Biochemists\| PubMed ID: 20011209	2009
Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Diabetes research and clinical practice\| PubMed ID: 20092903	2010
Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. Journal of molecular endocrinology\| PubMed ID: 21821716	2011
Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion. The Journal of biological chemistry\| PubMed ID: 22065581	2011
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308370	2012
Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-ÎºB signalling. PloS one\| PubMed ID: 22558381	2012
Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics. Journal of proteome research\| PubMed ID: 22578083	2012
The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. The Journal of biological chemistry\| PubMed ID: 23335512	2013
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes\| PubMed ID: 23378607	2013
Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23520164	2013
The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Trends in endocrinology and metabolism: TEM\| PubMed ID: 23631851	2013
Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic Î²-Cells. Diabetes\| PubMed ID: 23656887	2013
Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3 Beta in Pancreatic Beta Cells. The Journal of biological chemistry\| PubMed ID: 23853095	2013