a-simple-rapid-immunocytochemical-assay-for-quantifying-surface

A Simple and Rapid Immunocytochemical Assay for Quantifying Surface Receptor Abundance in Cultured Cells

Synaptic transmission is a fundamental process through which neurons communicate. This mechanism involves the release of neurotransmitters&#8212;such as ...

Capital Medical University

We aimed to determine the association of indices of body composition with abnormal metabolic phenotype, and to examine whether the strength of association was differentially distributed in different age groups in normal-weight Chinese adults. A total of 3015 normal-weight adults from a survey of Chinese people encompassing health and basic physiological parameters was included in this cross-sectional study. We investigated the association of body composition measured by bioelectrical impedance analysis and conventional body indices with metabolically unhealthy normal-weight (MUHNW) adults, divided by age groups and gender. Associations were assessed by multiple logistic regression analysis. We found abnormal metabolism in lean Chinese adults to be associated with higher adiposity indices (body mass index, BMI), waist circumference, and percentage body fat), lower skeletal muscle %, and body water %. Body composition was differentially distributed in age groups within the metabolically healthy normal weight (MHNW)/MUHNW groups. The impact of factors related to MUHNW shows a decreasing trend with advancing age in females and disparities of factors (BMI, body fat %, skeletal muscle %, and body water %) associated with the MUHNW phenotype in the elderly was noticed. Those factors remained unchanged in males throughout the age range, while the association of BMI, body fat %, skeletal muscle %, and body water % to MUHNW attenuated and grip strength emerged as a protective factor in elderly females. These results suggest that increased adiposity and decreased skeletal muscle mass are associated with unfavorable metabolic traits in normal-weight Chinese adults, and that MUHNW is independent of BMI, while increased waist circumference appears to be indicative of an abnormal metabolic phenotype in elderly females.

Association between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults.

Aspirin may improve treatment outcomes and increase the survival of patients with prostate cancer, but the results remain controversial.

Aspirin use improves the biochemical control of prostate cancer in Chinese men.

vonoprazan, a novel potassium-competitive acid blocking agent, has better clinical outcomes in the treatment of acid-related diseases. However, some adverse events have been associated with vonoprazan for the treatment of acid-associated diseases. Therefore, this systematic review and meta-analysis aimed to explore the safety and tolerability of vonoprazan for acid-associated diseases.

Adverse events of vonoprazan in the treatments of acid-related diseases: a systematic review and meta-analysis.

A type of gastric mucosal injury disease known as gastric ulcer (GU) is clearly connected to the aberrant release of gastric acid. Traditional botanicals have the potential for anti-inflammation, anti-oxidation, and other multitarget therapies, as well as being safe.

Xiangshao Decoction alleviates gastric mucosal injury through NRF2 signaling pathway and reduces neuroinflammation in gastric ulcer rats.

Glycoproteins are proteins that contain oligosaccharide chains. As widely distributed functional proteins in the body, glycoproteins are essential for cellular development, cellular function maintenance, and intercellular communication. Glycoproteins not only play a role in the cell and the membrane, but they are also secreted in the intercell. These secreted glycoproteins are critical to the central nervous system for neurodevelopment and synaptic transmission. More specifically, secreted glycoproteins play indispensable roles in neurite growth mediation, axon guiding, synaptogenesis, neuronal differentiation, the release of synaptic vesicles, subunit composition of neurotransmitter receptors, and neurotransmitter receptor trafficking among other things. Abnormal expressions of secreted glycoproteins in the central nervous system are associated with abnormal neuron development, impaired synaptic organization/transmission, and neuropsychiatric disorders. This article reviews the secreted glycoproteins that regulate neuronal development and synaptic function in the central nervous system, and the molecular mechanism of these regulations, providing reference for research about synaptic function regulation and related central nervous system diseases.

Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System.

Gastric ulcer (GU) is the injury of the gastric mucosa caused by the stimulation of various pathogenic factors penetrating the deep mucosal muscle layer. An increasing number of studies have shown that traditional Chinese medicine (TCM) is highly effective in treating GU due to its multitarget, multilevel, and multi-pathway effects.

Treatment of gastric ulcer, traditional Chinese medicine may be a better choice.

Intrinsic capacity (IC), representing an individual's full range of physical and mental abilities, is influenced by objective socioeconomic status (SES); however, the impact of subjective SES remains unclear.

Association of objective and subjective socioeconomic status with intrinsic capacity deficits among community-dwelling middle-aged and older adults in China: A cross-sectional study.

Non-scarring alopecia, encompassing androgenetic alopecia (AGA), alopecia areata (AA), and telogen effluvium (TE), is a common skin condition that significantly impacts both the physical and psychological wellbeing of affected individuals. This review aims to delve into the multifactorial etiology of non-scarring alopecia and to critically assess the current and emerging treatment options available for management.

Research progress in the treatment of non-scarring alopecia: mechanism and treatment.

Hair greying is a common aspect of the natural ageing process. Although it is generally not considered a medical problem, its high prevalence can substantially impact emotional state due to aesthetic concerns. A growing body of research has demonstrated that natural products and their derivatives derived from plants possess advantages and potential in the treatment of hair greying.

Article	Year
Association between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults. International journal of environmental research and public health\| PubMed ID: 28387701	2017
Aspirin use improves the biochemical control of prostate cancer in Chinese men. Journal of B.U.ON. : official journal of the Balkan Union of Oncology\| PubMed ID: 30610806	2018
Adverse events of vonoprazan in the treatments of acid-related diseases: a systematic review and meta-analysis. Revista espanola de enfermedades digestivas\| PubMed ID: 36353962	2023
Xiangshao Decoction alleviates gastric mucosal injury through NRF2 signaling pathway and reduces neuroinflammation in gastric ulcer rats. Phytomedicine : international journal of phytotherapy and phytopharmacology\| PubMed ID: 37451149	2023
Secreted Glycoproteins That Regulate Synaptic Function: the Dispatchers in the Central Nervous System. Molecular neurobiology\| PubMed ID: 37924485	2024
Treatment of gastric ulcer, traditional Chinese medicine may be a better choice. Journal of ethnopharmacology\| PubMed ID: 38278376	2024
Association of objective and subjective socioeconomic status with intrinsic capacity deficits among community-dwelling middle-aged and older adults in China: A cross-sectional study. The Journal of frailty & aging\| PubMed ID: 40063621	2025
Research progress in the treatment of non-scarring alopecia: mechanism and treatment. Frontiers in pharmacology\| PubMed ID: 40487405	2025
Natural products and their derivatives as candidate treatments for hair greying: from drug discovery to molecular mechanisms. Chinese medicine\| PubMed ID: 41634821	2026

Haiying Gong

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