salvianolic-acid-b-suppresses-epithelial-mesenchymal-transition

Salvianolic Acid B Suppresses Epithelial-Mesenchymal Transition-Associated Phenotypes in Cervical Cancer Cells via GPIb Alpha/LYN/TWIST1 Signaling

Cervical cancer remains a major gynecological malignancy, and the epithelial-mesenchymal transition is associated with tumor progression. Salvianolic acid ...

Anhui medical university

Anhui Provincial Women and Children's Medical Center

The Food and Drug Administration recently announced that the use of morcellation may cause fibroids or pelvic dissemination and metastasis of uterine sarcoma; therefore, the use of morcellation is limited in the USA. A large sample study is necessary to assess the proportion of uterine malignant tumors found in patients with laparoscopic myomectomy.

Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China.

We report a case of primary ovarian Burkitt lymphoma that occurred in a 25-year-old woman. The patient complained of a mass in the right ovary discerned by physical examination 2 months prior. Ultrasound examination indicated that the right ovary was enlarged and abundant blood flow signals were observed. Right salpingo-oophorectomy was subsequently performed. Histology was characterized by diffuse sheets of monotonous medium-sized lymphoid cells with plentiful mitotic figures and apoptosis. Numerous tingible-body macrophages were found in the ovarian tissue, presenting a starry sky pattern. The tumor cells expressed CD20, CD10, 6 and  in the absence of . Ki-67 proliferative index was very high with a proliferation rate of near 100%.  (8q24) rearrangement was detected by fluorescence in situ hybridization (FISH) with no  (18q21) and  (3q37) gene rearrangements. Cumulative evidence established primary ovarian Burkitt lymphoma as the final histopathologic diagnosis with clinical stage I (FIGO). The patient received HyperCVAD chemotherapy after surgery and remained complete response (CR) for 18 months. We aim to provide insight into the future treatment of this rare but lethal disease.

Primary ovarian Burkitt lymphoma: report of a case and review of literature.

Currently, people all over the world have been affected by coronavirus disease 2019 (COVID-19). Fighting against COVID-19 is the top priority for all the countries and nations. The development of a safe and effective COVID-19 vaccine is considered the optimal way of ending the pandemic. Three hundred and 44 vaccines were in development, with 149 undergoing clinical research and 35 authorized for emergency use as to March 15 of 2022. Many studies have shown the effective role of COVID-19 vaccines in preventing SARS-CoV-2 infections as well as serious and fatal COVID-19 cases. However, tough challenges have arisen regarding COVID-19 vaccines, including long-term immunity, emerging COVID-19 variants, and vaccine inequalities. A systematic review was performed of recent COVID-19 vaccine studies, with a focus on vaccine type, efficacy and effectiveness, and protection against SARS-CoV-2 variants, breakthrough infections, safety, deployment and vaccine strategies used in the real-world. Ultimately, there is a need to establish a unified evaluation standard of vaccine effectiveness, monitor vaccine safety and effectiveness, along with the virological characteristics of SARS-CoV-2 variants; and determine the most useful booster schedule. These aspects must be coordinated to ensure timely responses to beneficial or detrimental situations. In the future, global efforts should be directed toward effective and immediate vaccine allocations, improving vaccine coverage, SARS-CoV-2 new variants tracking, and vaccine booster development.

Comprehensive narrative review of real-world COVID-19 vaccines: viewpoints and opportunities.

We aimed to explore the clinicopathological characteristics and prognostic risk factors of cervical cancer in patients aged ≤35 years. A total of 256 cervical cancer patients treated at Anhui Medical University Affiliated Maternity and Child Health Hospital and The First Affiliated Hospital of Anhui Medical University from January 2016 to October 2018 were divided into ≤35-year-old (n = 136) and >35-year-old (n = 120) groups. Their clinicopathological characteristics and 3-year cumulative disease-free survival (DFS) and overall survival (OS) rates were compared. The factors influencing the 3-year cumulative DFS rate of patients in the ≤35-year-old group were analyzed using univariate and multivariate Cox regression models. The human papillomavirus (HPV) infection rate, incidence rate of contact vaginal bleeding, depth of cervical interstitial infiltration, and incidence rates of parametrial metastasis and vascular infiltration were all significantly higher in the ≤35-year-old group than in the >35-year-old group. The 3-year cumulative DFS rates of all patients and those with HPV infection and contact vaginal bleeding were significantly lower in the ≤35-year-old group than in the >35-year-old group (69.12% vs. 77.50%, 68.29% vs. 80.85%, and 66.04% vs. 81.48%) (log-rank χ2 = 7.429, 4.339, and 4.276, P < .05). Depth of cervical interstitial infiltration >4 mm, parametrial metastasis, lymph node metastasis, and vascular infiltration were independent risk factors for the prognosis of cervical cancer patients aged ≤35 years (P < .05). Cervical cancer aged ≤35 years have a worse postoperative prognosis than those aged >35 years, which is affected by the depth of cervical interstitial infiltration >4 mm, parametrial metastasis, lymph node metastasis, and vascular infiltration. Therefore, it is necessary to identify more effective treatment methods for young patients with cervical cancer to improve the therapeutic effect and reduce the risk of recurrence and metastasis.

Clinicopathological characteristics and prognostic risk factors of cervical cancer patients aged ≤35 years old.

Maackiain (Mac), a flavonoid analog isolated from Sophora flavescens, exhibits neuroprotective, anti-allergic, anti-inflammatory, and pro-apoptotic effects. It is not clear whether Mac has a therapeutic effect on cervical cancer.

Maackiain suppresses the development of cervical cancer via AMPK priming autophagy.

Recent studies implicate that hypertensive disorders of pregnancy (HDP) is associated with gut microbiome. However, the different associations of different microbial features with HDP are little known. This study investigates the different associations of gut bacterial taxonomic composition, functional and network profiles with HDP.

Hypertensive disorders of pregnancy were more strongly associated with the functional and network profiles than with the community composition of the gut bacteriome: a pilot study.

Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a rare and highly aggressive malignancy with a poor prognosis. We report the case of a 36-year-old nulliparous woman with a history of HPV-18 infection and repeated cytology showing atypical squamous cells of undetermined significance (ASC-US), while multiple biopsies remained negative. She initially underwent surgery for multiple uterine leiomyomas and severe endometriosis. Ten months later, she presented with acute pelvic pain, rectal pressure, and minor vaginal bleeding. Combined hysteroscopy and laparoscopy revealed suspicious lesions, and histopathology with immunohistochemistry confirmed International Federation of Gynecology and Obstetrics (FIGO) stage IVB SCNEC. Postoperatively, she received platinum-based chemotherapy followed by salvage immunotherapy. Despite a transient decline in tumor markers, the disease progressed rapidly, with enlargement and confluence of pelvic lesions and extensive bone metastases, ultimately resulting in death from multiorgan failure. This case highlights the diagnostic challenges, early systemic dissemination, and poor outcomes of SCNEC, underscoring the urgent need for more effective therapeutic strategies.

Case Report: Diagnostic challenges in cervical small cell neuroendocrine carcinoma of a reproductive-age woman.

Cervical cancer remains a major cause of cancer-related morbidity and mortality in women, particularly among patients diagnosed with locally advanced, recurrent, or metastatic disease. Here, we investigated the role of transcriptional repressor GATA-binding 1 (TRPS1) in cervical cancer progression and defined its downstream regulatory mechanism. Bioinformatics analysis revealed differential expression of TRPS1 between cervical cancer and normal cervical tissues. To further explore its functional role, TRPS1 was overexpressed in cervical cancer cell lines via lentiviral infection. In vitro and in vivo experiments confirmed that TRPS1 expression was downregulated in cervical cancer, and its overexpression inhibited cervical cancer cell proliferation, migration, invasion, and stemness, as well as tumor growth in xenograft models. Mechanistically, ORC6 was identified as a candidate downstream effector of TRPS1. TRPS1 bound to the ORC6 promoter and repressed ORC6 transcription, leading to reduced ORC6 expression. Functional rescue experiments showed that ORC6 restoration partially reversed TRPS1-mediated inhibition of cell-cycle progression, apoptosis resistance, stemness-marker expression, EMT-associated marker expression, and tumor growth. Notably, low TRPS1 expression and high ORC6 expression were associated with lymphovascular invasion and lymph node metastasis in cervical cancer patients. Together, these findings identify a TRPS1-ORC6 regulatory axis that restrains cervical cancer stemness and progression.

TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness.

Anxiety is common among peri- and postmenopausal women, and many conventional treatments cause side effects. This multicenter, double-blind, randomized, placebo-controlled trial was conducted from December 2021 to June 2023 at 18 centers in China, enrolling 360 women aged 40‒65 years with menopausal anxiety. Participants were randomly assigned to receive Xiangshao granules (high-dose group,  = 180) or a placebo (very-low-dose group,  = 180) for 8 weeks. The primary outcome was the reductive ratio in self-rating anxiety scale (SAS) scores after 8 weeks, while secondary outcomes included the self-rating depression scale (SDS), Kupperman Index, and gastrointestinal symptom score (GIS). After eight weeks, the mean SAS reductive ratio was greater in the high-dose group than in the very-low-dose group (37.7% . 28.9%,  = 0.0052), and scores declined more in the high-dose than in the very-low-dose group, with a higher clinical improvement rate (69.8%  56.9%,  = 0.0151). Although no significant between-group differences were observed for SDS, Kupperman Index, or GIS, all showed improvements from baseline. Adverse event rates were comparable. Transcriptomic analysis revealed modifications in the dopaminergic synapse pathway following Xiangshao treatment, while network pharmacology identified FOS, ATF2, and CREB1 as key dopaminergic pathway-related targets. Metabolomic data corroborated these findings. Collectively, Xiangshao granules safely and effectively alleviate menopausal anxiety, potentially by modulating dopaminergic signaling.

Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial.

Article	Year
Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China. Chinese medical journal\| PubMed ID: 29133752	2017
Primary ovarian Burkitt lymphoma: report of a case and review of literature. International journal of clinical and experimental pathology\| PubMed ID: 35414839	2022
Comprehensive narrative review of real-world COVID-19 vaccines: viewpoints and opportunities. Medical review (2021)\| PubMed ID: 35862507	2022
Clinicopathological characteristics and prognostic risk factors of cervical cancer patients aged ≤35 years old. Medicine\| PubMed ID: 36550810	2022
Maackiain suppresses the development of cervical cancer via AMPK priming autophagy. The Journal of pharmacy and pharmacology\| PubMed ID: 37934902	2024
Hypertensive disorders of pregnancy were more strongly associated with the functional and network profiles than with the community composition of the gut bacteriome: a pilot study. BMC pregnancy and childbirth\| PubMed ID: 41029586	2025
Case Report: Diagnostic challenges in cervical small cell neuroendocrine carcinoma of a reproductive-age woman. Frontiers in oncology\| PubMed ID: 41293259	2025
TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness. Tissue & cell\| PubMed ID: 42247779	2026
Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled tri... Acta pharmaceutica Sinica. B\| PubMed ID: 42765076	2026

Yali Zhuang

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