a-standardized-workflow-for-multimodal-assessment-right-to-left

A Standardized Workflow for Multimodal Assessment of Right-to-Left Shunt&#8211;Related Ischemic Brain Injury

Right-to-left shunt (RLS) has been associated with cryptogenic stroke, migraine, and other neurological conditions in which ischemic brain injury may be ...

The Second Affiliated Hospital of Xiamen Medical College

The prevalence of dementia can vary by region and there is a cluster of more than 10 modifiable risk factors for dementia. Therefore, this study aimed to determine the prevalence of dementia in Xiamen, China, and identify independent risk factors associated with dementia.

Prevalence and risk factors of dementia in elder adults in Xiamen, China: A cross-sectional study.

BACKGROUND This study aimed to compare sleep architecture using the apnea-hypopnea index (AHI) and wake after sleep onset (WASO) in 150 participants aged 65 to 80 years with and without mild cognitive impairment (MCI), using polysomnography, actigraphy, and home sleep monitoring, and assessed cognitive performance using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). MATERIAL AND METHODS A total of 150 participants were enrolled, including 75 patients with MCI and 75 cognitively healthy controls. Sleep architecture was evaluated using polysomnography, actigraphy, and home sleep monitoring systems. Cognitive function was assessed using MMSE and MoCA. Differences in sleep parameters, including AHI and WASO, were compared between groups. Pearson correlation and multiple linear regression analyses were performed to evaluate associations between sleep parameters and cognitive scores. RESULTS Compared with controls, the MCI group showed significantly reduced slow-wave sleep duration (22.6±14.6 vs 45.3±16.7 min; P<0.01), increased WASO (42.5±7.1% vs 29.1±5.9%; P<0.01), and higher AHI (18.7±6.2 vs 5.3±2.0; P<0.01). Slow-wave sleep duration was positively correlated with MMSE (r=0.72; P<0.01) and MoCA (r=0.68; P<0.01), whereas WASO was negatively correlated with MMSE (r=-0.65; P<0.01) and MoCA (r=-0.63; P<0.01). Multiple linear regression analysis demonstrated that slow-wave sleep duration remained independently associated with cognitive performance (ß=0.41; P<0.001). CONCLUSIONS Alterations in sleep architecture, particularly reduced slow-wave sleep and increased nocturnal wakefulness, are significantly associated with poorer cognitive performance in older adults with MCI. Multi-channel sleep monitoring may facilitate early identification of sleep-related cognitive impairment and support clinical evaluation.

Article	Year
Prevalence and risk factors of dementia in elder adults in Xiamen, China: A cross-sectional study. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society\| PubMed ID: 36353810	2023
Comparison of Sleep Architecture in Individuals Aged 65 to 80 Years With and Without Mild Cognitive Impairment Using Multi-Channel Sleep Monitoring. Medical science monitor : international medical journal of experimental and clinical research\| PubMed ID: 42487307	2026

Yanyan Huang

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