Ashok B. Kulkarni

Functional Genomics Section, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2026

Other Publications

Article	Year
Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. The Journal of biological chemistry\| PubMed ID: 11684694	2002
Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice. Current molecular medicine\| PubMed ID: 12041733	2002
Transforming growth factor-beta1 negatively regulates crystallin expression in teeth. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 12211442	2002
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. The Journal of biological chemistry\| PubMed ID: 12536148	2003
Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. The Journal of biological chemistry\| PubMed ID: 12721295	2003
Genetically altered mouse models: the good, the bad, and the ugly. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists\| PubMed ID: 12799320	2003
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. The Journal of biological chemistry\| PubMed ID: 12824184	2003
The receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenic pathway is elevated in amelogenin-null mice. The Journal of biological chemistry\| PubMed ID: 12851394	2003
Mutant superoxide dismutase 1 causes motor neuron degeneration independent of cyclin-dependent kinase 5 activation by p35 or p25. Journal of neurochemistry\| PubMed ID: 15009685	2004
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15067135	2004
Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. The Journal of cell biology\| PubMed ID: 15583034	2004
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15665076	2005
Cyclin-dependent kinase 5 activity regulates pain signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16407116	2006
Cdk5: a new player in pain signaling. Cell cycle (Georgetown, Tex.)\| PubMed ID: 16552189	2006
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. Molecular and cellular biology\| PubMed ID: 16648478	2006
Overexpression of transforming growth factor-beta1 in teeth results in detachment of ameloblasts and enamel defects. European journal of oral sciences\| PubMed ID: 16674659	2006
Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neuro-Signals\| PubMed ID: 16921254	2006-2007
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17194758	2007
TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17534148	2007
Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18239462	2008
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nature immunology\| PubMed ID: 18438410	2008
Overview: engineering transgenic constructs and mice. Current protocols in cell biology\| PubMed ID: 19283728	2009
Generation of transgenic mice. Current protocols in cell biology\| PubMed ID: 19283729	2009
Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 19348940	2009
Genetic evidence for key roles of decorin and biglycan in dentin mineralization. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 19379665	2009
Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Developmental biology\| PubMed ID: 19501582	2009
Overview: generation of gene knockout mice. Current protocols in cell biology\| PubMed ID: 19731224	2009
Manipulation of mouse embryonic stem cells for knockout mouse production. Current protocols in cell biology\| PubMed ID: 19731225	2009
Generation of gene knockout mice by ES cell microinjection. Current protocols in cell biology\| PubMed ID: 19731226	2009
Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. The American journal of pathology\| PubMed ID: 19948833	2010
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 20142803	2010
Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1. Biochemical and biophysical research communications\| PubMed ID: 20599762	2010
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation. Molecular biology of the cell\| PubMed ID: 20810788	2010
Molecular Roles of Cdk5 in Pain Signaling. Drug discovery today. Therapeutic strategies\| PubMed ID: 21253436	2009
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β. Nature immunology\| PubMed ID: 21297643	2011
A method for rapid demineralization of teeth and bones. The open dentistry journal\| PubMed ID: 21339898	2010
Resveratrol inhibits Cdk5 activity through regulation of p35 expression. Molecular pain\| PubMed ID: 21736731	2011
Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons. The Journal of biological chemistry\| PubMed ID: 22451679	2012
Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22456337	2012
MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma. Cancer letters\| PubMed ID: 23340180	2013
Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling. Journal of translational medicine\| PubMed ID: 23421960	2013
TGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells. Molecular pain\| PubMed ID: 23668392	2013
Inhibition of mTOR reduces anal carcinogenesis in transgenic mouse model. PloS one\| PubMed ID: 24124460	2013
TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PloS one\| PubMed ID: 24278477	2013
Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia. Molecular pain\| PubMed ID: 24359609	2013
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality. Journal of neuroinflammation\| PubMed ID: 24495352	2014
Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice. PloS one\| PubMed ID: 24658276	2014
Regulation of Sox6 by cyclin dependent kinase 5 in brain. PloS one\| PubMed ID: 24662752	2014
Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Science translational medicine\| PubMed ID: 24871130	2014
Tracking endogenous amelogenin and ameloblastin in vivo. PloS one\| PubMed ID: 24933156	2014
Adhesive and migratory effects of phosphophoryn are modulated by flanking peptides of the integrin binding motif. PloS one\| PubMed ID: 25396425	2014
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma. PloS one\| PubMed ID: 25723392	2015
Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis. Journal of dental research\| PubMed ID: 26503912	2016
PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma. Oncotarget\| PubMed ID: 26573233	2015
Targeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neurons. Pain\| PubMed ID: 26894912	2016
TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Scientific reports\| PubMed ID: 26902776	2016
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Scientific reports\| PubMed ID: 27108536	2016
Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma. Oncoimmunology\| PubMed ID: 27467947	2016
Inhibition of SRC family kinases reduces myeloid-derived suppressor cells in head and neck cancer. International journal of cancer\| PubMed ID: 27798955	2017
LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology\| PubMed ID: 27999760	2016
T-cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer. Molecular oncology\| PubMed ID: 28102051	2017
Selective blockade of B7-H3 enhances antitumour immune activity by reducing immature myeloid cells in head and neck squamous cell carcinoma. Journal of cellular and molecular medicine\| PubMed ID: 28401653	2017
Blockade of adenosine A2A receptor enhances CD8 T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma. Molecular cancer\| PubMed ID: 28592285	2017
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Pain\| PubMed ID: 28809765	2017
γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma. International journal of cancer\| PubMed ID: 29047105	2018
Meeting report: a hard look at the state of enamel research. International journal of oral science\| PubMed ID: 29165423	2017
Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception. Scientific reports\| PubMed ID: 29352128	2018
Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma. Oncoimmunology\| PubMed ID: 29632717	2018
Specific blockade CD73 alters the "exhausted" phenotype of T cells in head and neck squamous cell carcinoma. International journal of cancer\| PubMed ID: 29663369	2018
TGF-β receptor 1 regulates progenitors that promote browning of white fat. Molecular metabolism\| PubMed ID: 30100246	2018
Genome Editing in Mice Using CRISPR/Cas9 Technology. Current protocols in cell biology\| PubMed ID: 30178917	2018
The expression of PD-1 and LAG-3 in periapical lesions. American journal of translational research\| PubMed ID: 30210704	2018
Bi-allelic TMEM94 Truncating Variants Are Associated with Neurodevelopmental Delay, Congenital Heart Defects, and Distinct Facial Dysmorphism. American journal of human genetics\| PubMed ID: 30526868	2018
Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 30622300	2019
Correction: Behavioral and synaptic alterations relevant to obsessivecompulsive disorder in mice with increased EAAT3 expression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 30787427	2019
Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model. Human molecular genetics\| PubMed ID: 31189016	2019
Blockade of TIGIT/CD155 Signaling Reverses T-cell Exhaustion and Enhances Antitumor Capability in Head and Neck Squamous Cell Carcinoma. Cancer immunology research\| PubMed ID: 31387897	2019
Unique molecular signature in mucolipidosis type IV microglia. Journal of neuroinflammation\| PubMed ID: 31883529	2019
Cryopreservation Protocols for Genetically Engineered Mice. Current protocols\| PubMed ID: 34043268	2021
Protocols for Characterization of Cdk5 Kinase Activity. Current protocols\| PubMed ID: 34679246	2021
Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice. PloS one\| PubMed ID: 34780561	2021
Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5. Cell reports\| PubMed ID: 35263573	2022
Transcriptomic analysis of human sensory neurons in painful diabetic neuropathy reveals inflammation and neuronal loss. Scientific reports\| PubMed ID: 35304484	2022
Nociceptive signaling through transient receptor potential vanilloid 1 is regulated by Cyclin Dependent Kinase 5-mediated phosphorylation of T407 in vivo. Molecular pain\| PubMed ID: 35726573	2022
Integrative multiomic analyses of dorsal root ganglia in diabetic neuropathic pain using proteomics, phospho-proteomics, and metabolomics. Scientific reports\| PubMed ID: 36220867	2022
ACTIVATION OF CYCLIN-DEPENDENT KINASE 5 BROADENS ACTION POTENTIALS IN HUMAN SENSORY NEURONS. bioRxiv : the preprint server for biology\| PubMed ID: 37398398	2023
Multiprotein Assemblies, Phosphorylation and Dephosphorylation in Neuronal Cytoskeleton. bioRxiv : the preprint server for biology\| PubMed ID: 37502949	2023
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons. Molecular pain\| PubMed ID: 37982142	2023
Genotyping Protocols for Genetically Engineered Mice. Current protocols\| PubMed ID: 37984376	2023
A Retrospective Tribute to Dr. Harish Pant (1938-2023) and His Seminal Work on Cyclin Dependent Kinase 5. Neurochemical research\| PubMed ID: 39235580	2024
Transcriptome analysis of rheumatoid arthritis uncovers genes linked to inflammation-induced pain. Scientific reports\| PubMed ID: 39472517	2024
Human pain transcriptomics: lessons learned so far. Pain reports\| PubMed ID: 41635475	2026