association-between-sputum-consistency-extubation-mechanically

Association Between Sputum Consistency and Extubation in Mechanically Ventilated Patients with Severe Pneumonia Receiving Nebulized Antibiotic Therapy

Thick airway secretions may impair airway clearance and contribute to extubation failure in mechanically ventilated patients with severe pneumonia. ...

Guangxi Medical University, Nanning

This study was motivated by the needs of precise characterization for the ultradian and circadian rhythmicity of human core body temperature (CBT). The CBT data, two-whole-days' data of two female bed-ridden old aged suffering from cerebral infarction sequelae, was detrended to eliminate the long-term components with periods longer than two days and normalized at first. It was then analyzed by the stationary wavelets transform (SWT) to get the time-frequency information. In the step of SWT, symlet 6 was used, and the approximation waveforms in the 5th, 6th and 7th levels were used to reveal the targeted rhythmicity. The results of the SWT show that SWT can faithfully reveal the time-frequency information of feature elements (peaks and troughs) of waveforms and rhythmicity can be characterized by analyzing temporal information of feature elements.

Characterization of ultradian and circadian rhythms of core body temperature based on wavelet analysis.

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disorder with an increasing incidence rate. Despite advances in ALS research over the years, the precise etiology and pathogenic mechanisms remain largely elusive.

Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses.

This study aimed to assess the efficacy and safety of transarterial chemoembolization (TACE) in combination with apatinib (TACE-apatinib) for patients with unresectable hepatocellular carcinoma (HCC).

Transarterial chemoembolization plus apatinib for unresectable hepatocellular carcinoma: a multicenter, randomized, open-label, phase III trial.

Rheumatoid arthritis (RA) is a chronic, progressive inflammatory systemic autoimmune disease with incompletely understood etiology, causing substantial global disease burden. This study aimed to identify plasma proteins associated with RA using Mendelian randomization (MR) of large-scale plasma proteomics, providing potential biomarkers and therapeutic targets for early diagnosis and personalized treatment. We conducted a large-scale plasma proteome MR study using genetic data from 58,293 Europeans (14,361 RA patients and 43,932 controls) in a genome-wide association study. Plasma protein quantitative trait loci data for 4907 adaptors in 35,559 Icelanders were obtained from Ferkingstad et al. (2021). MR methods included MR-Egger, weighted median, inverse-variance weighting, Wald ratio, simple, and weighted models. Heterogeneity was assessed with Cochran Q test; horizontal pleiotropy was evaluated using the MR-Egger intercept and MR-PRESSO global test. Sensitivity was assessed by leave-one-out analysis. Analyses of gene ontology (describing biological functions), Kyoto Encyclopedia of Genes and Genomes (mapping functional pathways), and protein-protein interaction (identifying molecular interaction networks) were also performed. MR identified associations between 4907 plasma proteins and RA. Using an exploratory false discovery rate < 0.20, 11 novel plasma proteins were significantly associated. For example, genetically higher C2 levels increased RA risk (odds ratio per 1-standard deviation = 1.38; 95% confidence interval: 1.21-1.58), whereas higher USP25 decreased risk (odds ratio per 1-standard deviation = 0.61; 95% confidence interval: 0.48-0.79). C2, HS3ST3A1, MAPK3, PRSS57, and TNFAIP8 are potential risk factors; AIF1, ATF6, CXCL16, HMBS, DNASE1L2, and USP25 are protective. Inverse MR confirmed ATF6's negative correlation with RA risk. Gene ontology analysis indicated involvement in monocyte migration, leukocyte chemotaxis, and cytotaxis. Kyoto Encyclopedia of Genes an Genomes analysis revealed enrichment in pertussis, IL-17, and chemokine signaling pathways. Protein-protein interaction analysis by GeneMANIA identified 20 additional interacting genes and 416 links. This study highlights novel plasma proteins and pathways causally linked to RA, warranting functional and clinical follow-up to clarify biological roles and translational potential.

Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis.

Transarterial chemoembolization (TACE) alone has shown limited efficacy in improving survival among patients with unresectable hepatocellular carcinoma (HCC). This phase II trial compared TACE combined with camrelizumab (anti-PD-1 antibody) and rivoceranib (vascular endothelial growth factor receptor 2 inhibitor) versus TACE in unresectable HCC.

Transarterial Chemoembolization Combined With Camrelizumab and Rivoceranib for Unresectable Hepatocellular Carcinoma (CHANCE2005/CARES-005): A Randomized Phase II Trial.

OBJECTIVE: This study aims to compare the clinical efficacy of percutaneous laparoscopic-assisted gastrostomy (PLAG) and surgical gastrostomy (SG) for temporary gastrostomy in neonates with long-gap esophageal atresia (LGEA). METHODS: We conducted a retrospective analysis of 41 neonates diagnosed with LGEA who underwent temporary gastrostomy. Patients were retrospectively divided into two groups based on the year of surgery: the PLAG group (intervention group, n = 23,post-2020) and the SG group (historical control group, n = 18, pre-2020).We compared perioperative parameters, including postoperative fasting duration, gastrostomy closure rates, abdominal scar scores and complication rates between the two groups. RESULTS: No significant differences were found in baseline characteristics, including gender (p = 0.732), gestational age (p = 0.460), birth weight (p = 0.421), operative age (p = 0.165), Gross classification (p = 0.117), esophageal gap length (p = 0.081), or concomitant deformities (p = 0.767). The two groups showed no statistically significant differences in operative time (p = 0.067), intraoperative blood loss (p = 0.189), or postoperative fasting duration (p = 0.378). However, the PLAG group demonstrated clinically meaningful advantages in several outcomes, including significantly lower rates of gastrostomy closure (p < 0.001), improved cosmetic results (assessed by lower abdominal scar scores; p < 0.001), and reduced complication rates for stoma leakage (p < 0.001), peristomal dermatitis (p < 0.001), local infection (p < 0.001), and tube dislodgement (p = 0.003). No significant differences were noted in stomal hemorrhage (p = 0.083) or intra-abdominal fistula rates (p = 0.252). CONCLUSION: Compared to SG, PLAG offers significant advantages for temporary gastrostomy in LGEA, including lower closure requirements, improved cosmetic outcomes, and fewer overall complications. These findings support the broader clinical adoption of PLAG in this patient population.

Percutaneous laparoscopic-assisted gastrostomy outperforms surgical gastrostomy for temporary feeding in long-gap esophageal atresia: a comparative cohort study.

Article	Year
Characterization of ultradian and circadian rhythms of core body temperature based on wavelet analysis. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference\| PubMed ID: 25570923	2014
Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses. BMC neurology\| PubMed ID: 40033250	2025
Transarterial chemoembolization plus apatinib for unresectable hepatocellular carcinoma: a multicenter, randomized, open-label, phase III trial. BMC medicine\| PubMed ID: 40437469	2025
Plasma proteins and rheumatoid arthritis: A Mendelian randomization analysis. Medicine\| PubMed ID: 41261583	2025
Transarterial Chemoembolization Combined With Camrelizumab and Rivoceranib for Unresectable Hepatocellular Carcinoma (CHANCE2005/CARES-005): A Randomized Phase II Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 41734362	2026
Percutaneous laparoscopic-assisted gastrostomy outperforms surgical gastrostomy for temporary feeding in long-gap esophageal atresia: a comparative cohort study. Pediatric surgery international\| PubMed ID: 42001346	2026

Ming Huang

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