Max S. Wicha

Department of Internal Medicine, University of Michigan

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2014

Other Publications

Article	Year
Point: cancer stem cells--the evidence accumulates. Clinical chemistry\| PubMed ID: 23143328	2013
Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12629218	2003
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes & development\| PubMed ID: 12756227	2003
Stem cells in normal breast development and breast cancer. Cell proliferation\| PubMed ID: 14521516	2003
Breast cancer, stem/progenitor cells and the estrogen receptor. Trends in endocrinology and metabolism: TEM\| PubMed ID: 15223047	2004
New organizational and funds flow models for an academic cancer center. Academic medicine : journal of the Association of American Medical Colleges\| PubMed ID: 15234911	2004
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast cancer research : BCR\| PubMed ID: 15535842	2004
Survival of mammary stem cells in suspension culture: implications for stem cell biology and neoplasia. Journal of mammary gland biology and neoplasia\| PubMed ID: 15886888	2005
Mammary stem cells, self-renewal pathways, and carcinogenesis. Breast cancer research : BCR\| PubMed ID: 15987436	2005
Cancer stem cells: an old idea--a paradigm shift. Cancer research\| PubMed ID: 16488983	2006
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer research\| PubMed ID: 16778178	2006
Identification of murine mammary stem cells: implications for studies of mammary development and carcinogenesis. Breast cancer research : BCR\| PubMed ID: 16934104	2006
Cancer stem cells and metastasis: lethal seeds. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17020960	2006
Stem cells in mammary development and carcinogenesis: implications for prevention and treatment. Stem cell reviews\| PubMed ID: 17142857	2005
Mammary stem cell number as a determinate of breast cancer risk. Breast cancer research : BCR\| PubMed ID: 17688678	2007
Breast cancer stem cells: the other side of the story. Stem cell reviews\| PubMed ID: 17873342	2007
Breast cancer stem cells-research opportunities utilizing mathematical modeling. Stem cell reviews\| PubMed ID: 17873350	2007
Selective targeting of cancer stem cells: a new concept in cancer therapeutics. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy\| PubMed ID: 17896836	2007
Cancer stem cells: implications for cancer treatment and prevention. Cancer journal (Sudbury, Mass.)\| PubMed ID: 17921723	2007
[The cancer stem cell: the breast cancer driver]. Médecine sciences : M/S\| PubMed ID: 18154716	2007
BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18230721	2008
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell stem cell\| PubMed ID: 18371393	2007
Cancer stem cell heterogeneity in hereditary breast cancer. Breast cancer research : BCR\| PubMed ID: 18423071	2008
Cancer stem cells: a step toward the cure. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18539956	2008
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18539959	2008
Cancer stem cells in breast: current opinion and future challenges. Pathobiology : journal of immunopathology, molecular and cellular biology\| PubMed ID: 18544962	2008
Colon cancer stem cells: implications for prevention and therapy. Trends in molecular medicine\| PubMed ID: 18929507	2008
[Stem cells and epithelial cancers: the example of breast cancer]. Annales de pathologie\| PubMed ID: 18984292	2008
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer research\| PubMed ID: 19147559	2009
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer research\| PubMed ID: 19190339	2009
Tumor-initiating cells and treatment resistance: how goes the war? Journal of mammary gland biology and neoplasia\| PubMed ID: 19238526	2009
HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19276254	2009
Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer research\| PubMed ID: 19336570	2009
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS biology\| PubMed ID: 19492080	2009
Getting to the root of BRCA1-deficient breast cancer. Cell stem cell\| PubMed ID: 19733528	2009
Development of 'synthetic lethal' strategies to target BRCA1-deficient breast cancer. Breast cancer research : BCR\| PubMed ID: 19804613	2009
Retinoid signaling regulates breast cancer stem cell differentiation. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19806016	2009
An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19808871	2009
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast cancer research and treatment\| PubMed ID: 19898931	2010
Identification of single chain antibodies to breast cancer stem cells using phage display. Biotechnology progress\| PubMed ID: 19899107	2009
Targeting breast cancer stem cells. Breast (Edinburgh, Scotland)\| PubMed ID: 19914544	2009
Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20028757	2010
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. The Journal of clinical investigation\| PubMed ID: 20051626	2010
Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head & neck\| PubMed ID: 20073073	2010
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 20388854	2010
Cancer stem cells: nature versus nurture. Nature cell biology\| PubMed ID: 20418873	2010
Targeting breast cancer stem cells. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20498387	2010
Breast tumors: of mice and women. Breast cancer research : BCR\| PubMed ID: 20550730	2010
Targeting breast cancer stem cells. Molecular oncology\| PubMed ID: 20599450	2010
Stem cells in normal development and cancer. Progress in molecular biology and translational science\| PubMed ID: 21075331	2010
Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer research\| PubMed ID: 21098716	2010
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer research\| PubMed ID: 21224357	2011
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. The Journal of nutritional biochemistry\| PubMed ID: 21295962	2011
Stemming a tumor with a little miR. Nature medicine\| PubMed ID: 21297608	2011
Circulating tumor cells: not all detected cells are bad and not all bad cells are detected. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 21422428	2011
Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. International journal of cancer. Journal international du cancer\| PubMed ID: 21480217	2012
Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival. Cancer research\| PubMed ID: 21498635	2011
Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21685479	2011
Ablation of breast cancer stem cells with radiation. Translational oncology\| PubMed ID: 21804918	2011
Inflammation and autophagy conspire to promote tumor growth. Cell cycle (Georgetown, Tex.)\| PubMed ID: 21829104	2011
Breast cancer stem cells, cytokine networks, and the tumor microenvironment. The Journal of clinical investigation\| PubMed ID: 21965337	2011
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22308314	2012
Role of microRNAs in the regulation of breast cancer stem cells. Journal of mammary gland biology and neoplasia\| PubMed ID: 22331423	2012
Antiangiogenic agents: fueling cancer's hypoxic roots. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22421155	2012
Cancer stem cell vaccination confers significant antitumor immunity. Cancer research\| PubMed ID: 22473314	2012
PSA lo and behold: prostate cancer stem cells. Cell stem cell\| PubMed ID: 22560068	2012
MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS genetics\| PubMed ID: 22685420	2012
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Molecular cell\| PubMed ID: 22819326	2012
Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22833047	2012
HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23091114	2012
Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame? Breast cancer research : BCR\| PubMed ID: 23153392	2012
Targeting cancer stem cells via dendritic-cell vaccination. Oncoimmunology\| PubMed ID: 23243607	2012
Breast cancer stem cells: we've got them surrounded. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23251003	2013
Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23340294	2013
B4 androgen ablation: attacking the prostate cancer stem cell. The Journal of clinical investigation\| PubMed ID: 23348735	2013
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer research\| PubMed ID: 23442322	2013
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23444212	2013
HER2 and breast cancer stem cells: more than meets the eye. Cancer research\| PubMed ID: 23740771	2013
Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer research\| PubMed ID: 23832665	2013
Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clinical immunology (Orlando, Fla.)\| PubMed ID: 23994769	2013
The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype. Endocrine-related cancer\| PubMed ID: 24025583	2013
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets. Nature nanotechnology\| PubMed ID: 24077027	2013
Clinical trial design for testing the stem cell model for the prevention and treatment of cancer. Cancers\| PubMed ID: 24212828	2011
Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24- Subpopulations of Breast Cancer Cells. PloS one\| PubMed ID: 24376586	2013