Zheng-Rong Lu

Department of Biomedical Engineering, Case Western Reserve University

Affiliated withCase Western Reserve University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2013

Other Publications

Article	Year
Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging. Pharmaceutical research\| PubMed ID: 16729223	2006
Design of novel bioconjugates for targeted drug delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 11772458	2002
Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. Pharmaceutical research\| PubMed ID: 11883637	2002
Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharmaceutical research\| PubMed ID: 12033370	2002
Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging. Bioconjugate chemistry\| PubMed ID: 12862423	2003
Extracellular biodegradable macromolecular gadolinium(III) complexes for MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 14705042	2004
PEG-g-poly(GdDTPA-co-L-cystine): a biodegradable macromolecular blood pool contrast agent for MR imaging. Bioconjugate chemistry\| PubMed ID: 15546211	2004
Contrast-enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 15799038	2005
Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent. Pharmaceutical research\| PubMed ID: 15846467	2005
PEG-g-poly(GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRI. Biomacromolecules\| PubMed ID: 16004476	2005
Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1,6-elimination spacer. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16290118	2006
Effect of size and charge on pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide Gd(III) complexes. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16631270	2006
Pharmacokinetics, biodistribution and contrast enhanced MR blood pool imaging of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers in a rat model. Pharmaceutical research\| PubMed ID: 16850267	2006
Contrast enhanced MRI-guided photodynamic therapy for site-specific cancer treatment. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 16902981	2006
Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging. Magnetic resonance imaging\| PubMed ID: 16916710	2006
Noninvasive visualization of in vivo drug delivery of poly(L-glutamic acid) using contrast-enhanced MRI. Molecular pharmaceutics\| PubMed ID: 17009849	2006
Contrast-enhanced magnetic resonance angiography with biodegradable (Gd-DTPA)-cystamine copolymers: comparison with MS-325 in a swine model. Molecular pharmaceutics\| PubMed ID: 17009855	2006
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 17150276	2007
Gadolinium(III)-based blood-pool contrast agents for magnetic resonance imaging: status and clinical potential. Expert opinion on drug delivery\| PubMed ID: 17335412	2007
Application of biomedical imaging in drug discovery and development. Pharmaceutical research\| PubMed ID: 17380256	2007
Noninvasive visualization of pharmacokinetics, biodistribution and tumor targeting of poly[N-(2-hydroxypropyl)methacrylamide] in mice using contrast enhanced MRI. Pharmaceutical research\| PubMed ID: 17387601	2007
A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 17582638	2007
Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 17659618	2007
Polymer platforms for drug delivery and biomedical imaging. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 17662500	2007
Synthesis, characterization, and gene delivery of poly-L-lysine octa(3-aminopropyl)silsesquioxane dendrimers: nanoglobular drug carriers with precisely defined molecular architectures. Molecular pharmaceutics\| PubMed ID: 17705440	2007
In Vivo evaluation of a PAMAM-cystamine-(Gd-DO3A) conjugate as a biodegradable macromolecular MRI contrast agent. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 17720954	2007
Polydisulfide Gd(III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents. International journal of nanomedicine\| PubMed ID: 17722260	2006
RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker alpha(v) beta3 integrin with MRT, mapping. International journal of nanomedicine\| PubMed ID: 17722547	2007
Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 17888541	2007
A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery. Biomaterials\| PubMed ID: 17923154	2008
Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery. Bioconjugate chemistry\| PubMed ID: 17939730	2007
[Determination of the lung function by impulse oscillometry in 549 healthy children in Chengdu area]. Zhonghua er ke za zhi. Chinese journal of pediatrics\| PubMed ID: 18211755	2007
Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 18567541	2008
Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate. Pharmaceutical research\| PubMed ID: 18584312	2008
Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules\| PubMed ID: 18771313	2008
Structural effect on degradability and in vivo contrast enhancement of polydisulfide Gd(III) complexes as biodegradable macromolecular MRI contrast agents. Magnetic resonance imaging\| PubMed ID: 18814987	2009
Characterization of tumor angiogenesis with dynamic contrast-enhanced MRI and biodegradable macromolecular contrast agents in mice. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 19025902	2008
A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI. Bioconjugate chemistry\| PubMed ID: 19053180	2008
A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 19135104	2009
Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice. Molecular pharmaceutics\| PubMed ID: 19296675	2009
Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier. Biomaterials\| PubMed ID: 19595449	2009
Tumor characterization with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in mice. Pharmaceutical research\| PubMed ID: 19597972	2009
Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 19629979	2009
Rapid simultaneous acquisition of T1 and T2 mapping images using multishot double spin-echo EPI and automated variations of TR and TE (ms-DSEPI-T12). NMR in biomedicine\| PubMed ID: 19777499	2010
Noninvasive evaluation of antiangiogenic effect in a mouse tumor model by DCE-MRI with Gd-DTPA cystamine copolymers. Molecular pharmaceutics\| PubMed ID: 19958031	2010
Molecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man. Advanced drug delivery reviews\| PubMed ID: 20060431	2010
Peptide-targeted Nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging. Biomacromolecules\| PubMed ID: 20131758	2010
Stability and biodistribution of a biodegradable macromolecular MRI contrast agent Gd-DTPA cystamine copolymers (GDCC) in rats. Pharmaceutical research\| PubMed ID: 20393871	2010
An effective targeted nanoglobular manganese(II) chelate conjugate for magnetic resonance molecular imaging of tumor extracellular matrix. Molecular pharmaceutics\| PubMed ID: 20481565	2010
[Findings of electric bronchoscopy in 67 children with recurrent wheezing]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics\| PubMed ID: 20540854	2010
New amphiphilic carriers forming pH-sensitive nanoparticles for nucleic acid delivery. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 20672851	2010
Synthesis and evaluation of nanoglobule-cystamine-(Gd-DO3A), a biodegradable nanosized magnetic resonance contrast agent for dynamic contrast-enhanced magnetic resonance urography. International journal of nanomedicine\| PubMed ID: 20957222	2010
Polydisulfide Based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents. Israel journal of chemistry\| PubMed ID: 21331318	2010
Synthesis and evaluation of nanoglobular macrocyclic Mn(II) chelate conjugates as non-gadolinium(III) MRI contrast agents. Bioconjugate chemistry\| PubMed ID: 21473650	2011
Integrin Targeted MR Imaging. Theranostics\| PubMed ID: 21547154	2011
Ocular pharmacokinetic study using Tâ‚ mapping and Gd-chelate- labeled polymers. Pharmaceutical research\| PubMed ID: 21691891	2011
Polydisulfide manganese(II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 22031457	2012
MR molecular imaging of prostate cancer with a peptide-targeted contrast agent in a mouse orthotopic prostate cancer model. Pharmaceutical research\| PubMed ID: 22139536	2012
Synthesis and evaluation of a peptide targeted small molecular Gd-DOTA monoamide conjugate for MR molecular imaging of prostate cancer. Bioconjugate chemistry\| PubMed ID: 22812444	2012
Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu. International journal of cancer. Journal international du cancer\| PubMed ID: 22987116	2013
Gadolinium-based contrast agents for magnetic resonance cancer imaging. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology\| PubMed ID: 23047730	2013
Albumin pre-coating enhances intracellular siRNA delivery of multifunctional amphiphile/siRNA nanoparticles. International journal of nanomedicine\| PubMed ID: 23055731	2012
Molecular MRI of liver fibrosis by a peptide-targeted contrast agent in an experimental mouse model. Investigative radiology\| PubMed ID: 23192162	2013
Synthesis and Evaluation of a Targeted Nanoglobular Dual-Modal Imaging Agent for MR Imaging and Image-Guided Surgery of Prostate Cancer. Pharmaceutical research\| PubMed ID: 23471641	2013
Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging. Contrast media & molecular imaging\| PubMed ID: 23606425	2013
Molecular Magnetic Resonance Imaging of Tumors with a PTPÂµ Targeted Contrast Agent. Translational oncology\| PubMed ID: 23730413	2013
Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 23796431	2013
Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI. Biomaterials\| PubMed ID: 23863450	2013