Patrick M. Gaffney

Arthritis and Clinical Immunology, oklahoma medical research foundation

Affiliated withoklahoma medical research foundation

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 15	2013

Other Publications

Article	Year
Recent advances in the genetics of systemic lupus erythematosus. Rheumatic diseases clinics of North America\| PubMed ID: 11840693	2002
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. American journal of human genetics\| PubMed ID: 12145745	2002
Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12604793	2003
Pearl, a novel family of putative transposable elements in bivalve mollusks. Journal of molecular evolution\| PubMed ID: 12612834	2003
Genetic variability assessed by microsatellites in a breeding program of Pacific white shrimp (Litopenaeus vannamei). Marine biotechnology (New York, N.Y.)\| PubMed ID: 14595549	2004
Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer research\| PubMed ID: 14729608	2004
The use of microarrays to study autoimmunity. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research\| PubMed ID: 14870980	2004
Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. American journal of human genetics\| PubMed ID: 15273934	2004
Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Novartis Foundation symposium\| PubMed ID: 15999805	2005
Complete mitochondrial DNA sequence of the eastern oyster Crassostrea virginica. Marine biotechnology (New York, N.Y.)\| PubMed ID: 16132463	2005
c-kit expression in adenoid cystic carcinoma does not have an impact on local or distant tumor recurrence. Head & neck\| PubMed ID: 16240323	2005
Gene expression profiling in human autoimmunity. Immunological reviews\| PubMed ID: 16623768	2006
Fine-mapping chromosome 20 in 230 systemic lupus erythematosus sib pair and multiplex families: evidence for genetic epistasis with chromosome 16q12. American journal of human genetics\| PubMed ID: 16642431	2006
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma. Oral oncology\| PubMed ID: 16762588	2006
Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer research\| PubMed ID: 16849536	2006
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17412832	2007
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nature genetics\| PubMed ID: 18059267	2008
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nature genetics\| PubMed ID: 18204446	2008
Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activity. American journal of physiology. Cell physiology\| PubMed ID: 18385288	2008
A novel polymorphism of the human CD40 receptor with enhanced function. Blood\| PubMed ID: 18591382	2008
Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and ... Human molecular genetics\| PubMed ID: 19129174	2009
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nature genetics\| PubMed ID: 19165918	2008
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19329491	2009
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 19333917	2009
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis and rheumatism\| PubMed ID: 19333953	2009
A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 19644854	2009
European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 19644962	2009
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS genetics\| PubMed ID: 19851445	2009
Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 20191587	2010
Development of type I genetic markers from expressed sequence tags in highly polymorphic species. Marine biotechnology (New York, N.Y.)\| PubMed ID: 20309599	2011
Defining a new molecular basis of systemic lupus erythematosus through transcriptional profiling. Expert review of clinical immunology\| PubMed ID: 20477140	2007
Exon 6 variants carried on systemic lupus erythematosus (SLE) risk haplotypes modulate IRF5 function. Autoimmunity\| PubMed ID: 20695768	2011
The role of genetic variation near interferon-kappa in systemic lupus erythematosus. Journal of biomedicine & biotechnology\| PubMed ID: 20706608	2010
Fragmentation of the large subunit ribosomal RNA gene in oyster mitochondrial genomes. BMC genomics\| PubMed ID: 20813041	2010
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. American journal of human genetics\| PubMed ID: 21194677	2011
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nature genetics\| PubMed ID: 21336280	2011
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS genetics\| PubMed ID: 21379322	2011
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS genetics\| PubMed ID: 21408207	2011
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis and rheumatism\| PubMed ID: 21425124	2011
Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 21437871	2011
Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis and rheumatism\| PubMed ID: 21590681	2011
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS genetics\| PubMed ID: 21637784	2011
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 21719445	2011
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis and rheumatism\| PubMed ID: 21792837	2011
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 21952918	2012
Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Annals of the rheumatic diseases\| PubMed ID: 21978998	2012
The genomics of autoimmune disease in the era of genome-wide association studies and beyond. Autoimmunity reviews\| PubMed ID: 22001415	2012
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematos... Annals of the rheumatic diseases\| PubMed ID: 22088620	2012
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Annals of the rheumatic diseases\| PubMed ID: 22110124	2012
Sex chromosome aneuploidies among men with systemic lupus erythematosus. Journal of autoimmunity\| PubMed ID: 22154021	2012
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS genetics\| PubMed ID: 22174698	2011
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22203994	2012
Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis and rheumatism\| PubMed ID: 22231568	2012
Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus. Arthritis research & therapy\| PubMed ID: 22364570	2012
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. American journal of human genetics\| PubMed ID: 22464253	2012
Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions. Journal of biomedicine & biotechnology\| PubMed ID: 22500098	2012
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Annals of the rheumatic diseases\| PubMed ID: 22523428	2012
Two independent functional risk haplotypes in TNIP1 are associated with systemic lupus erythematosus. Arthritis and rheumatism\| PubMed ID: 22833143	2012
RBPJ mutations identified in two families affected by Adams-Oliver syndrome. American journal of human genetics\| PubMed ID: 22883147	2012
Impact of genetic ancestry and socio-demographic status on the clinical expression of systemic lupus erythematosus in Amerindian-European populations. Arthritis and rheumatism\| PubMed ID: 22886787	2012
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Annals of the rheumatic diseases\| PubMed ID: 22904263	2012
WITHDRAWN: A female autoimmunity gene exists: DDX3X. Medical hypotheses\| PubMed ID: 22917660	2012
The oyster genome reveals stress adaptation and complexity of shell formation. Nature\| PubMed ID: 22992520	2012
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nature genetics\| PubMed ID: 23042117	2012
Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. American journal of human genetics\| PubMed ID: 23084292	2012
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS genetics\| PubMed ID: 23441136	2013
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS genetics\| PubMed ID: 23468661	2013
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nature genetics\| PubMed ID: 23603761	2013
Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. The Journal of rheumatology\| PubMed ID: 23637325	2013
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation. Arthritis and rheumatism\| PubMed ID: 23666743	2013
Encore: Genetic Association Interaction Network centrality pipeline and application to SLE exome data. Genetic epidemiology\| PubMed ID: 23740754	2013
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS genetics\| PubMed ID: 23874208	2013
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PloS one\| PubMed ID: 23950893	2013
ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 23970121	2013
An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. PLoS genetics\| PubMed ID: 24039598	2013
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nature genetics\| PubMed ID: 24097067	2013
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS genetics\| PubMed ID: 24130510	2013
Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Human molecular genetics\| PubMed ID: 24163247	2013