David D. Shock

Laboratory of Structural Biology, NIEHS, National Institutes of Health

Affiliated withNIEHS, National Institutes of Health

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 26	2013

Other Publications

Article	Year
Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. The Journal of biological chemistry\| PubMed ID: 11756435	2002
Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. The Journal of biological chemistry\| PubMed ID: 12023286	2002
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. The Journal of biological chemistry\| PubMed ID: 12370169	2002
Rapid segmental and subdomain motions of DNA polymerase beta. The Journal of biological chemistry\| PubMed ID: 12458221	2003
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. The Journal of biological chemistry\| PubMed ID: 12777390	2003
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates. The Journal of biological chemistry\| PubMed ID: 15145936	2004
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. The Journal of biological chemistry\| PubMed ID: 15561706	2005
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. The Journal of biological chemistry\| PubMed ID: 15749700	2005
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (London, England : 1993)\| PubMed ID: 16084394	2005
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (London, England : 1993)\| PubMed ID: 16615916	2006
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17079493	2006
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. The Journal of biological chemistry\| PubMed ID: 17355977	2007
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell\| PubMed ID: 18471977	2008
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides,... Journal of medicinal chemistry\| PubMed ID: 18811136	2008
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic letters\| PubMed ID: 19351147	2009
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". The Journal of biological chemistry\| PubMed ID: 19759017	2009
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20724659	2010
Base excision repair and design of small molecule inhibitors of human DNA polymerase Î². Cellular and molecular life sciences : CMLS\| PubMed ID: 20844920	2010
Substrate channeling in mammalian base excision repair pathways: passing the baton. The Journal of biological chemistry\| PubMed ID: 20952393	2010
Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic acids research\| PubMed ID: 22169953	2012
Binary complex crystal structure of DNA polymerase Î² reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22178760	2012
Stereospecific formation of a ternary complex of (S)-Î±,Î²-fluoromethylene-dATP with DNA pol Î². Chembiochem : a European journal of chemical biology\| PubMed ID: 22315190	2012
Effect of Î²,Î³-CHF- and Î²,Î³-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase Î². Biochemistry\| PubMed ID: 23043620	2012
Amino acid substitution in the active site of DNA polymerase Î² explains the energy barrier of the nucleotidyl transfer reaction. Journal of the American Chemical Society\| PubMed ID: 23647366	2013
Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site. The Journal of biological chemistry\| PubMed ID: 23798703	2013
Observing a DNA polymerase choose right from wrong. Cell\| PubMed ID: 23827680	2013