Samuel H. Wilson

Laboratory of Structural Biology, NIEHS, National Institutes of Health

Affiliated withNIEHS, National Institutes of Health National Institute of Environmental Health Sciences, National Institutes of Health

Research Area

Biography

Samuel H. Wilson has not added Biography.
If you are Samuel H. Wilson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 26	2013
Publication title	2022

Other Publications

Article	Year
The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities. The Journal of biological chemistry\| PubMed ID: 11733530	2002
Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. The Journal of biological chemistry\| PubMed ID: 11756435	2002
DNA polymerase beta. The international journal of biochemistry & cell biology\| PubMed ID: 11854030	2002
1H, 13C and 15N resonance assignments for the perdeuterated 22 kD palm-thumb domain of DNA polymerase beta. Journal of biomolecular NMR\| PubMed ID: 11883786	2002
Polymerase beta simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se. Journal of molecular biology\| PubMed ID: 11955015	2002
Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11983862	2002
Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen. The Journal of biological chemistry\| PubMed ID: 12063248	2002
Binary system for selective photoaffinity labeling of base excision repair DNA polymerases. Nucleic acids research\| PubMed ID: 12136121	2002
Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. The Journal of biological chemistry\| PubMed ID: 12370169	2002
Rapid segmental and subdomain motions of DNA polymerase beta. The Journal of biological chemistry\| PubMed ID: 12458221	2003
Mapping of the interaction interface of DNA polymerase beta with XRCC1. Structure (London, England : 1993)\| PubMed ID: 12467578	2002
Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage. DNA repair\| PubMed ID: 12509250	2002
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA repair\| PubMed ID: 12509266	2003
Structure of DNA polymerase beta with the mutagenic DNA lesion 8-oxodeoxyguanine reveals structural insights into its coding potential. Structure (London, England : 1993)\| PubMed ID: 12517346	2003
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. The Journal of biological chemistry\| PubMed ID: 12665521	2003
DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress. Biological chemistry\| PubMed ID: 12674496	2003
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. DNA repair\| PubMed ID: 12713817	2003
Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002. DNA repair\| PubMed ID: 12713820	2003
The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair. The Journal of biological chemistry\| PubMed ID: 12734201	2003
Structural insights into the origins of DNA polymerase fidelity. Structure (London, England : 1993)\| PubMed ID: 12737815	2003
Localization of the deoxyribose phosphate lyase active site in human DNA polymerase iota by controlled proteolysis. The Journal of biological chemistry\| PubMed ID: 12777390	2003
Suppressed catalytic activity of base excision repair enzymes on rotationally positioned uracil in nucleosomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12799467	2003
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. The Journal of biological chemistry\| PubMed ID: 12882965	2003
Cloning and characterization of a novel member of the human ATF/CREB family: ATF2 deletion, a potential regulator of the human DNA polymerase beta promoter. Gene\| PubMed ID: 12909347	2003
Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens. Cancer research\| PubMed ID: 14522902	2003
High-level expression and purification of untagged and histidine-tagged HIV-1 reverse transcriptase. Protein expression and purification\| PubMed ID: 14766302	2004
Recombinogenic phenotype of human activation-induced cytosine deaminase. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15034045	2004
Shaping science policy in the age of genomics. Nature reviews. Genetics\| PubMed ID: 15134075	2004
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate. DNA repair\| PubMed ID: 15135726	2004
Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates. The Journal of biological chemistry\| PubMed ID: 15145936	2004
Highly organized but pliant active site of DNA polymerase beta: compensatory mechanisms in mutant enzymes revealed by dynamics simulations and energy analyses. Biophysical journal\| PubMed ID: 15189842	2004
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. The Journal of clinical investigation\| PubMed ID: 15199406	2004
The Environmental Genome Project: phase I and beyond. Molecular interventions\| PubMed ID: 15210868	2004
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. Journal of the American Chemical Society\| PubMed ID: 15238001	2004
Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta. Biochemistry\| PubMed ID: 15248749	2004
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping. The Journal of biological chemistry\| PubMed ID: 15258144	2004
AP endonuclease-independent DNA base excision repair in human cells. Molecular cell\| PubMed ID: 15260972	2004
In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15365186	2004
Structural insights into DNA polymerase beta deterrents for misincorporation support an induced-fit mechanism for fidelity. Structure (London, England : 1993)\| PubMed ID: 15458631	2004
DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. The Journal of biological chemistry\| PubMed ID: 15561706	2005
Base excision repair in nucleosomes lacking histone tails. DNA repair\| PubMed ID: 15590328	2005
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. The Journal of biological chemistry\| PubMed ID: 15701627	2005
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and ... Nucleic acids research\| PubMed ID: 15731342	2005
DNA polymerase lambda mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. The Journal of biological chemistry\| PubMed ID: 15749700	2005
REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. DNA repair\| PubMed ID: 15950550	2005
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death. DNA repair\| PubMed ID: 16002346	2005
Personalized exposure assessment: promising approaches for human environmental health research. Environmental health perspectives\| PubMed ID: 16002370	2005
DNA polymerase lambda protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. The Journal of biological chemistry\| PubMed ID: 16002405	2005
Strategic planning: establishing need and clarifying motivation. Environmental health perspectives\| PubMed ID: 16079048	2005
Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (London, England : 1993)\| PubMed ID: 16084394	2005
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism. DNA repair\| PubMed ID: 16172026	2005
Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity. Biochemistry\| PubMed ID: 16201758	2005
The need for exposure health sciences. Environmental health perspectives\| PubMed ID: 16203220	2005
Framework for environmental exposure research: the disease-first approach. Molecular interventions\| PubMed ID: 16249520	2005
Syn-full behavior by T7 DNA polymerase. Structure (London, England : 1993)\| PubMed ID: 16271879	2005
A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase beta ternary complex. Biochemistry\| PubMed ID: 16285726	2005
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic acids research\| PubMed ID: 16449207	2006
Structure and mechanism of DNA polymerase Beta. Chemical reviews\| PubMed ID: 16464010	2006
Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (London, England : 1993)\| PubMed ID: 16615916	2006
Determination of lysine pK values using [5-13C]lysine: application to the lyase domain of DNA Pol beta. Journal of the American Chemical Society\| PubMed ID: 16787052	2006
Activities and mechanism of DNA polymerase beta. Methods in enzymology\| PubMed ID: 16793365	2006
Disease-first: a new paradigm for environmental health science research. Environmental health perspectives\| PubMed ID: 16835037	2006
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer research\| PubMed ID: 16885342	2006
Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16938895	2006
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA repair\| PubMed ID: 16982218	2006
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage. Molecular cell\| PubMed ID: 17018297	2006
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17079493	2006
Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency. DNA repair\| PubMed ID: 17113833	2007
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. DNA repair\| PubMed ID: 17127106	2007
Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: improved accuracy in studies of structural features and mutational ef... Journal of molecular biology\| PubMed ID: 17174326	2007
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry\| PubMed ID: 17176036	2006
Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta. Biochemistry\| PubMed ID: 17209556	2007
ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA repair\| PubMed ID: 17292679	2007
Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal\| PubMed ID: 17293403	2007
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta. The Journal of biological chemistry\| PubMed ID: 17355977	2007
Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair\| PubMed ID: 17363341	2007
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature\| PubMed ID: 17450122	2007
Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress. Chemical research in toxicology\| PubMed ID: 17567156	2007
Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic acids research\| PubMed ID: 17576692	2007
The X family portrait: structural insights into biological functions of X family polymerases. DNA repair\| PubMed ID: 17631059	2007
Exploring the role of large conformational changes in the fidelity of DNA polymerase beta. Proteins\| PubMed ID: 17671961	2008
Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry\| PubMed ID: 17686777	2007
Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research\| PubMed ID: 17720705	2007
HMGB1 is a cofactor in mammalian base excision repair. Molecular cell\| PubMed ID: 17803946	2007
(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society\| PubMed ID: 18031037	2007
DNA polymerase beta fidelity: halomethylene-modified leaving groups in pre-steady-state kinetic analysis reveal differences at the chemical transition state. Biochemistry\| PubMed ID: 18161950	2008
XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research\| PubMed ID: 18166976	2008
Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18391201	2008
DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion. Biochemical and biophysical research communications\| PubMed ID: 18433721	2008
Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair\| PubMed ID: 18434259	2008
Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell\| PubMed ID: 18471977	2008
Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18614692	2008
Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction\| PubMed ID: 18650495	2008
Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair\| PubMed ID: 18691676	2008
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides,... Journal of medicinal chemistry\| PubMed ID: 18811136	2008
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research\| PubMed ID: 19188258	2009
Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic letters\| PubMed ID: 19351147	2009
Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research\| PubMed ID: 19635489	2009
Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one\| PubMed ID: 19654874	2009
Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry\| PubMed ID: 19674974	2009
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research\| PubMed ID: 19684079	2009
PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA repair\| PubMed ID: 19717351	2009
DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair\| PubMed ID: 19748837	2009
DNA polymerase beta substrate specificity: side chain modulation of the "A-rule". The Journal of biological chemistry\| PubMed ID: 19759017	2009
DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair\| PubMed ID: 20006562	2010
HMGB1: roles in base excision repair and related function. Biochimica et biophysica acta\| PubMed ID: 20123074	2010
FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Molecular cancer research : MCR\| PubMed ID: 20145043	2010
Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues. Journal of the American Chemical Society\| PubMed ID: 20465217	2010
DNA polymerase beta ribonucleotide discrimination: insertion, misinsertion, extension, and coding. The Journal of biological chemistry\| PubMed ID: 20519499	2010
Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology\| PubMed ID: 20526335	2010
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks. DNA repair\| PubMed ID: 20573551	2010
DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research\| PubMed ID: 20696268	2010
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20724659	2010
DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one\| PubMed ID: 20805875	2010
Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology\| PubMed ID: 20828826	2010
Base excision repair and design of small molecule inhibitors of human DNA polymerase Î². Cellular and molecular life sciences : CMLS\| PubMed ID: 20844920	2010
Substrate channeling in mammalian base excision repair pathways: passing the baton. The Journal of biological chemistry\| PubMed ID: 20952393	2010
Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair\| PubMed ID: 21130714	2011
Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry\| PubMed ID: 21733843	2011
Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase Î². Nucleic acids research\| PubMed ID: 21917855	2012
Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PloS one\| PubMed ID: 21935361	2011
Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic acids research\| PubMed ID: 22169953	2012
Binary complex crystal structure of DNA polymerase Î² reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22178760	2012
Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular cancer research : MCR\| PubMed ID: 22246237	2012
DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences\| PubMed ID: 22285516	2012
Stereospecific formation of a ternary complex of (S)-Î±,Î²-fluoromethylene-dATP with DNA pol Î². Chembiochem : a European journal of chemical biology\| PubMed ID: 22315190	2012
Î²,Î³-CHF- and Î²,Î³-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society\| PubMed ID: 22397499	2012
HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry\| PubMed ID: 22736760	2012
Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England : 1993)\| PubMed ID: 22959623	2012
DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry\| PubMed ID: 22989888	2012
Pol Î² associated complex and base excision repair factors in mouse fibroblasts. Nucleic acids research\| PubMed ID: 23042675	2012
Effect of Î²,Î³-CHF- and Î²,Î³-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase Î². Biochemistry\| PubMed ID: 23043620	2012
DNA polymerase Î² gap-filling translesion DNA synthesis. Chemical research in toxicology\| PubMed ID: 23121263	2012
Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies. Nucleic acids research\| PubMed ID: 23125368	2013
Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae. PloS one\| PubMed ID: 23144716	2012
Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PloS one\| PubMed ID: 23145148	2012
Predicting enhanced cell killing through PARP inhibition. Molecular cancer research : MCR\| PubMed ID: 23193155	2013
DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic acids research\| PubMed ID: 23267011	2013
Perspective: pre-chemistry conformational changes in DNA polymerase mechanisms. Theoretical chemistry accounts\| PubMed ID: 23459563	2012
Amino acid substitution in the active site of DNA polymerase Î² explains the energy barrier of the nucleotidyl transfer reaction. Journal of the American Chemical Society\| PubMed ID: 23647366	2013
Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site. The Journal of biological chemistry\| PubMed ID: 23798703	2013
Interaction between DNA Polymerase Î² and BRCA1. PloS one\| PubMed ID: 23826138	2013
Observing a DNA polymerase choose right from wrong. Cell\| PubMed ID: 23827680	2013
Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair\| PubMed ID: 23871146	2013
Understanding the loss-of-function in a triple missense mutant of DNA polymerase Î² found in prostate cancer. International journal of oncology\| PubMed ID: 23877444	2013
Structure and mechanism of DNA polymerase β. Biochemistry\| PubMed ID: 24717170	2014
Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nature structural & molecular biology\| PubMed ID: 24777061	2014
The dark side of DNA repair. eLife\| PubMed ID: 24844708	2014
Phylogenetic analysis and evolutionary origins of DNA polymerase X-family members. DNA repair\| PubMed ID: 25112931	2014
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature\| PubMed ID: 25409153	2015
Structures of human DNA polymerases ν and θ expose their end game. Nature structural & molecular biology\| PubMed ID: 25837870	2015
Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP. Organic letters\| PubMed ID: 25970636	2015
New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis. DNA repair\| PubMed ID: 26002198	2015
Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26243878	2015
Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26351676	2015
Capturing snapshots of APE1 processing DNA damage. Nature structural & molecular biology\| PubMed ID: 26458045	2015
Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability. Nucleic acids research\| PubMed ID: 26980281	2016
Insertion of oxidized nucleotide triggers rapid DNA polymerase opening. Nucleic acids research\| PubMed ID: 27034465	2016
Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts. Environmental health perspectives\| PubMed ID: 27082013	2016
Enzymatic Activity Assays for Base Excision Repair Enzymes in Cell Extracts from Vertebrate Cells. Bio-protocol\| PubMed ID: 27390764	2015
Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism. Structure (London, England : 1993)\| PubMed ID: 27642161	2016
Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine. The Journal of biological chemistry\| PubMed ID: 27660390	2016
DNA polymerase β contains a functional nuclear localization signal at its N-terminus. Nucleic acids research\| PubMed ID: 27956495	2017
Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites. Inorganic chemistry\| PubMed ID: 27976880	2017
Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature communications\| PubMed ID: 28067232	2017
Revealing the role of the product metal in DNA polymerase β catalysis. Nucleic acids research\| PubMed ID: 28108654	2017
DNA polymerase β uses its lyase domain in a processive search for DNA damage. Nucleic acids research\| PubMed ID: 28119421	2017
Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nature communications\| PubMed ID: 28811466	2017
Assay to Measure DNA Polymerase β Nucleotide Insertion Coupled with the DNA Ligation Reaction during Base Excision Repair. Bio-protocol\| PubMed ID: 28835905	2017
Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic acids research\| PubMed ID: 28973450	2017
Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of radiation research\| PubMed ID: 28992331	2017
DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria. DNA repair\| PubMed ID: 29100041	2017
XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity. DNA repair\| PubMed ID: 29477978	2018
Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29610342	2018
Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry\| PubMed ID: 29874056	2018
Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State. Biochemistry\| PubMed ID: 29889506	2018
Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis. Nucleic acids research\| PubMed ID: 29917149	2018
DNA scanning by base excision repair enzymes and implications for pathway coordination. DNA repair\| PubMed ID: 30181039	2018
Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nature communications\| PubMed ID: 30310068	2018
Repair pathway for PARP-1 DNA-protein crosslinks. DNA repair\| PubMed ID: 30466837	2019
A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β. Biochemistry\| PubMed ID: 30839203	2019
Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β. The Journal of biological chemistry\| PubMed ID: 30885943	2019
Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism. Annual review of biochemistry\| PubMed ID: 31220977	2019
The Pol β variant containing exon α is deficient in DNA polymerase but has full dRP lyase activity. Scientific reports\| PubMed ID: 31289286	2019
DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair. The Enzymes\| PubMed ID: 31627875	2019
Shining light on the response to repair intermediates in DNA of living cells. DNA repair\| PubMed ID: 31790865	2020
DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context. The Journal of biological chemistry\| PubMed ID: 31801827	2020
Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair. DNA repair\| PubMed ID: 31945542	2020
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a DNA Methyltransferase. Cells\| PubMed ID: 31963223	2020
Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry\| PubMed ID: 31999437	2020
WITHDRAWN: Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC). DNA repair\| PubMed ID: 32151818	2020
Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts. Scientific reports\| PubMed ID: 32221313	2020
Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC). DNA repair\| PubMed ID: 32438305	2020
Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus. Communications biology\| PubMed ID: 32620932	2020
Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate. ACS omega\| PubMed ID: 32637805	2020
Lysines in the lyase active site of DNA polymerase β destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition. The Journal of biological chemistry\| PubMed ID: 32647014	2020
Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nature communications\| PubMed ID: 33824325	2021
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells. DNA repair\| PubMed ID: 34116475	2021
Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair. Nature communications\| PubMed ID: 34417448	2021
Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nature communications\| PubMed ID: 35680862	2022