Brendan W. Wren

Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine

Affiliated withLondon School of Hygiene & Tropical Medicine London School of Hygiene and Tropical Medicine

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 4	2013
Publication title Cited by 2	2020

Other Publications

Article	Year
A novel paralogous gene family involved in phase-variable flagella-mediated motility in Campylobacter jejuni. Microbiology (Reading, England)\| PubMed ID: 11832511	2002
Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Molecular microbiology\| PubMed ID: 11985725	2002
Helicobacter pylori adherence to gastric epithelial cells: a role for non-adhesin virulence genes. Journal of medical microbiology\| PubMed ID: 12018657	2002
Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system. Molecular microbiology\| PubMed ID: 12067350	2002
Deciphering tsetse's secret partner. Nature genetics\| PubMed ID: 12410225	2002
N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science (New York, N.Y.)\| PubMed ID: 12459590	2002
Signature-tagged mutagenesis of Yersinia pestis. Advances in experimental medicine and biology\| PubMed ID: 12756725	2003
Campylobacter--a tale of two protein glycosylation systems. Trends in microbiology\| PubMed ID: 12781527	2003
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis. Genome research\| PubMed ID: 12952873	2003
Genes to genetic immunization: identification of bacterial vaccine candidates. Methods (San Diego, Calif.)\| PubMed ID: 14511951	2003
The yersiniae--a model genus to study the rapid evolution of bacterial pathogens. Nature reviews. Microbiology\| PubMed ID: 15040180	2003
Adaptation of Campylobacter jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract. Infection and immunity\| PubMed ID: 15213117	2004
Invertebrates as a source of emerging human pathogens. Nature reviews. Microbiology\| PubMed ID: 15378047	2004
Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses. Molecular microbiology\| PubMed ID: 15612919	2005
The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nature genetics\| PubMed ID: 15640799	2005
Revised nomenclature of Clostridium difficile toxins and associated genes. Journal of medical microbiology\| PubMed ID: 15673503	2005
Protein glycosylation in bacterial mucosal pathogens. Nature reviews. Microbiology\| PubMed ID: 15738950	2005
Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway. Molecular microbiology\| PubMed ID: 15752194	2005
The Campylobacter jejuni glycome. FEMS microbiology reviews\| PubMed ID: 15808749	2005
Explorative multifactor approach for investigating global survival mechanisms of Campylobacter jejuni under environmental conditions. Applied and environmental microbiology\| PubMed ID: 15812042	2005
Comparative phylogenomics of pathogenic bacteria by microarray analysis. Current opinion in microbiology\| PubMed ID: 16125441	2005
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16230626	2005
Intestinal innate immunity to Campylobacter jejuni results in induction of bactericidal human beta-defensins 2 and 3. Infection and immunity\| PubMed ID: 16239524	2005
Serotype differences and lack of biofilm formation characterize Yersinia pseudotuberculosis infection of the Xenopsylla cheopis flea vector of Yersinia pestis. Journal of bacteriology\| PubMed ID: 16428415	2006
Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori. Helicobacter\| PubMed ID: 16579841	2006
Application of comparative phylogenomics to study the evolution of Yersinia enterocolitica and to identify genetic differences relating to pathogenicity. Journal of bacteriology\| PubMed ID: 16672618	2006
Numerical analysis of DNA microarray data of Campylobacter jejuni strains correlated with survival, cytolethal distending toxin and haemolysin analyses. International journal of medical microbiology : IJMM\| PubMed ID: 16782402	2006
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nature genetics\| PubMed ID: 16804543	2006
The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes. Vaccine\| PubMed ID: 17049676	2007
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS genetics\| PubMed ID: 17173484	2006
A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Cellular microbiology\| PubMed ID: 17521327	2007
Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence. BMC genomics\| PubMed ID: 17565669	2007
Clostridium difficile comes of age. Future microbiology\| PubMed ID: 17661635	2006
Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni. The Journal of biological chemistry\| PubMed ID: 17675288	2007
The second century of Campylobacter research: recent advances, new opportunities and old problems. Current opinion in infectious diseases\| PubMed ID: 17762786	2007
Deletion of a previously uncharacterized flagellar-hook-length control gene fliK modulates the sigma54-dependent regulon in Campylobacter jejuni. Microbiology (Reading, England)\| PubMed ID: 17768253	2007
The RovA regulons of Yersinia enterocolitica and Yersinia pestis are distinct: evidence that many RovA-regulated genes were acquired more recently than the core genome. Molecular microbiology\| PubMed ID: 17784909	2007
Bacterial pathogenomics. Nature\| PubMed ID: 17943120	2007
Comparative genome analyses of the pathogenic Yersiniae based on the genome sequence of Yersinia enterocolitica strain 8081. Advances in experimental medicine and biology\| PubMed ID: 17966400	2007
Campylobacter jejuni-mediated disease pathogenesis: an update. Transactions of the Royal Society of Tropical Medicine and Hygiene\| PubMed ID: 18023831	2008
The importance of the Rcs phosphorelay in the survival and pathogenesis of the enteropathogenic yersiniae. Microbiology (Reading, England)\| PubMed ID: 18375804	2008
Assessing the role of p-cresol tolerance in Clostridium difficile. Journal of medical microbiology\| PubMed ID: 18480332	2008
Microarray analysis of the transcriptional responses of Clostridium difficile to environmental and antibiotic stress. Journal of medical microbiology\| PubMed ID: 18480334	2008
Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences. Journal of medical microbiology\| PubMed ID: 18480336	2008
Microarray analysis of campylobacter jejuni: to the guts of the problem! Comparative and functional genomics\| PubMed ID: 18629262	2002
Microarrays for bacterial pathogens - hope or hype? Comparative and functional genomics\| PubMed ID: 18629265	2002
Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. BMC microbiology\| PubMed ID: 18844996	2008
YtxR acts as an overriding transcriptional off switch for the Yersinia enterocolitica Ysc-Yop type 3 secretion system. Journal of bacteriology\| PubMed ID: 19011024	2009
Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis, and colonization of chickens. Infection and immunity\| PubMed ID: 19307210	2009
Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis. Microbiology (Reading, England)\| PubMed ID: 19383703	2009
N-linked glycosylation in bacteria: an unexpected application. Future microbiology\| PubMed ID: 19416010	2009
Clostridium difficile--a continually evolving and problematic pathogen. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases\| PubMed ID: 19539054	2009
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infection and immunity\| PubMed ID: 19564382	2009
New levels of sophistication in the transcriptional landscape of bacteria. Genome biology\| PubMed ID: 19664196	2009
Recent advances in systems microbiology. Current opinion in microbiology\| PubMed ID: 19748820	2009
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome biology\| PubMed ID: 19781061	2009
Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens. BMC genomics\| PubMed ID: 19874620	2009
Simple sequence repeats in Helicobacter canadensis and their role in phase variable expression and C-terminal sequence switching. BMC genomics\| PubMed ID: 20105305	2010
Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. The Journal of infectious diseases\| PubMed ID: 20113177	2010
Evolutionary dynamics of Clostridium difficile over short and long time scales. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20368420	2010
Administration of capsule-selective endosialidase E minimizes upregulation of organ gene expression induced by experimental systemic infection with Escherichia coli K1. Microbiology (Reading, England)\| PubMed ID: 20395269	2010
Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. BMC microbiology\| PubMed ID: 20540813	2010
Liposomal delivery of p-ialB and p-omp25 DNA vaccines improves immunogenicity but fails to provide full protection against B. melitensis challenge. Genetic vaccines and therapy\| PubMed ID: 20637091	2010
Effect of chicken meat environment on gene expression of Campylobacter jejuni and its relevance to survival in food. International journal of food microbiology\| PubMed ID: 20858569	2011
Systems analysis of bacterial glycomes. Biochemical Society transactions\| PubMed ID: 20863301	2010
Glycoproteomics: a powerful tool for characterizing the diverse glycoforms of bacterial pilins and flagellins. Biochemical Society transactions\| PubMed ID: 20863304	2010
Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. PloS one\| PubMed ID: 21085698	2010
Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology (Reading, England)\| PubMed ID: 21183572	2011
Biofilm development on Caenorhabditis elegans by Yersinia is facilitated by quorum sensing-dependent repression of type III secretion. PLoS pathogens\| PubMed ID: 21253572	2011
In-depth genetic analysis of Clostridium difficile PCR-ribotype 027 strains reveals high genome fluidity including point mutations and inversions. Gut microbes\| PubMed ID: 21327033	2010
Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes. Environmental microbiology\| PubMed ID: 21418497	2011
Identification and characterisation of a novel adhesin Ifp in Yersinia pseudotuberculosis. BMC microbiology\| PubMed ID: 21527009	2011
The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains. BMC microbiology\| PubMed ID: 21527013	2011
The Campylobacter jejuni transcriptional regulator Cj1556 plays a role in the oxidative and aerobic stress response and is important for bacterial survival in vivo. Journal of bacteriology\| PubMed ID: 21642451	2011
The Campylobacter jejuni NCTC11168 capsule prevents excessive cytokine production by dendritic cells. Medical microbiology and immunology\| PubMed ID: 21863342	2012
Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage. Journal of medical microbiology\| PubMed ID: 21903827	2012
BμG@Sbase--a microbial gene expression and comparative genomic database. Nucleic acids research\| PubMed ID: 21948792	2012
Bacterial epidemiology and biology--lessons from genome sequencing. Genome biology\| PubMed ID: 22027015	2011
Hypervirulent Clostridium difficile PCR-ribotypes exhibit resistance to widely used disinfectants. PloS one\| PubMed ID: 22039420	2011
Identification of immunogenic and virulence-associated Campylobacter jejuni proteins. Clinical and vaccine immunology : CVI\| PubMed ID: 22155767	2012
Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infection and immunity\| PubMed ID: 22252864	2012
Evidence of Yersinia pestis DNA from fleas in an endemic plague area of Zambia. BMC research notes\| PubMed ID: 22280795	2012
Increase in Campylobacter jejuni invasion of intestinal epithelial cells under low-oxygen coculture conditions that reflect the in vivo environment. Infection and immunity\| PubMed ID: 22354027	2012
Characterization of the structurally diverse N-linked glycans of Campylobacter species. Journal of bacteriology\| PubMed ID: 22389484	2012
Macro and micro diversity of Clostridium difficile isolates from diverse sources and geographical locations. PloS one\| PubMed ID: 22396735	2012
Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design. Journal of medical microbiology\| PubMed ID: 22516134	2012
The Clostridium difficile spo0A gene is a persistence and transmission factor. Infection and immunity\| PubMed ID: 22615253	2012
Phenotypic and genotypic characterizations of Campylobacter jejuni isolated from the broiler meat production process. Current microbiology\| PubMed ID: 22735984	2012
The continually evolving Clostridium difficile species. Future microbiology\| PubMed ID: 22913354	2012
Neutrophil extracellular traps exhibit antibacterial activity against burkholderia pseudomallei and are influenced by bacterial and host factors. Infection and immunity\| PubMed ID: 22927051	2012
Campylobacter jejuni outer membrane vesicles play an important role in bacterial interactions with human intestinal epithelial cells. Infection and immunity\| PubMed ID: 22966047	2012
Gene function hypotheses for the Campylobacter jejuni glycome generated by a logic-based approach. Journal of molecular biology\| PubMed ID: 23103756	2013
Comparative phylogenomics of Streptococcus pneumoniae isolated from invasive disease and nasopharyngeal carriage from West Africans. BMC genomics\| PubMed ID: 23107513	2012
Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature genetics\| PubMed ID: 23222960	2013
Characterisation of Clostridium difficile biofilm formation, a role for Spo0A. PloS one\| PubMed ID: 23236376	2012
Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy\| PubMed ID: 23263008	2013
Population biology of Streptococcus pneumoniae in West Africa: multilocus sequence typing of serotypes that exhibit different predisposition to invasive disease and carriage. PloS one\| PubMed ID: 23342041	2013
Escherichia coli pathotypes in Pakistan from consecutive floods in 2010 and 2011. The American journal of tropical medicine and hygiene\| PubMed ID: 23358642	2013
Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays. Environmental microbiology\| PubMed ID: 23530835	2013
Campylobacter jejuni lipooligosaccharide sialylation, phosphorylation, and amide/ester linkage modifications fine-tune human Toll-like receptor 4 activation. The Journal of biological chemistry\| PubMed ID: 23629657	2013
Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23630351	2013
Transcriptional analysis of temporal gene expression in germinating Clostridium difficile 630 endospores. PloS one\| PubMed ID: 23691138	2013
Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis. Open biology\| PubMed ID: 23697804	2013
Improved bacterial mutagenesis by high-frequency allele exchange, demonstrated in Clostridium difficile and Streptococcus suis. Applied and environmental microbiology\| PubMed ID: 23728809	2013
The agr locus regulates virulence and colonization genes in Clostridium difficile 027. Journal of bacteriology\| PubMed ID: 23772065	2013
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli. Infection and immunity\| PubMed ID: 23798529	2013
Bacteria like sharing their sweets. Molecular microbiology\| PubMed ID: 23844892	2013
Gene content and diversity of the loci encoding biosynthesis of capsular polysaccharides of the 15 serovar reference strains of Haemophilus parasuis. Journal of bacteriology\| PubMed ID: 23873912	2013
Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae. Veterinary research\| PubMed ID: 23895236	2013
Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s). PloS one\| PubMed ID: 23922820	2013
Generation of a Tn5 transposon library in Haemophilus parasuis and analysis by transposon-directed insertion-site sequencing (TraDIS). Veterinary microbiology\| PubMed ID: 23928120	2013