Sakthivel Sadayappan

Department of Cell and Molecular Physiology, Loyola University Chicago

Affiliated withLoyola University Chicago

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2013

Other Publications

Article	Year
Novel deletions in MYH7 and MYBPC3 identified in Indian families with familial hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology\| PubMed ID: 12788380	2003
In vivo and in vitro analysis of cardiac troponin I phosphorylation. The Journal of biological chemistry\| PubMed ID: 15507454	2005
Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation\| PubMed ID: 15867176	2005
Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients. Atherosclerosis\| PubMed ID: 16102773	2006
Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circulation research\| PubMed ID: 16224063	2005
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. Journal of molecular and cellular cardiology\| PubMed ID: 17010989	2006
Cardiac myosin binding protein C phosphorylation is cardioprotective. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17075052	2006
Novel mitochondrial DNA mutations implicated in Noonan syndrome. International journal of cardiology\| PubMed ID: 17092585	2007
Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. The Journal of biological chemistry\| PubMed ID: 17575272	2007
Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circulation research\| PubMed ID: 17615373	2007
Role of the acidic N' region of cardiac troponin I in regulating myocardial function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17984178	2008
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation\| PubMed ID: 17984378	2007
The death of transcriptional chauvinism in the control and regulation of cardiac contractility. Annals of the New York Academy of Sciences\| PubMed ID: 18375572	2008
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nature genetics\| PubMed ID: 19151713	2009
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation\| PubMed ID: 19237661	2009
Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation research\| PubMed ID: 19299645	2009
Phosphorylation and function of cardiac myosin binding protein-C in health and disease. Journal of molecular and cellular cardiology\| PubMed ID: 19962384	2010
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. The Journal of biological chemistry\| PubMed ID: 20018870	2010
Targeted genome-wide enrichment of functional regions. PloS one\| PubMed ID: 20585402	2010
Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle. Journal of molecular and cellular cardiology\| PubMed ID: 20850451	2010
Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. The Journal of biological chemistry\| PubMed ID: 21148481	2011
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research\| PubMed ID: 21597010	2011
Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical journal\| PubMed ID: 21961592	2011
Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. Journal of molecular and cellular cardiology\| PubMed ID: 21971072	2012
Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. Journal of molecular and cellular cardiology\| PubMed ID: 21978630	2012
Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart failure\| PubMed ID: 22178992	2012
Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain. The Journal of biological chemistry\| PubMed ID: 22235120	2012
Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury. Biomarkers in medicine\| PubMed ID: 22296197	2012
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. Journal of muscle research and cell motility\| PubMed ID: 22527638	2012
Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. Journal of muscle research and cell motility\| PubMed ID: 22527640	2012
Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 22636676	2012
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibitio... Circulation\| PubMed ID: 22705886	2012
Cardiac myosin binding protein-C: redefining its structure and function. Biophysical reviews\| PubMed ID: 22707987	2012
In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure. Journal of molecular and cellular cardiology\| PubMed ID: 23220155	2013
GSK3Î² phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication. Circulation research\| PubMed ID: 23277198	2013
Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circulation research\| PubMed ID: 23508784	2013
Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart. Journal of molecular and cellular cardiology\| PubMed ID: 23624088	2013
Agonist activated PKCÎ²II translocation and modulation of cardiac myocyte contractile function. Scientific reports\| PubMed ID: 23756828	2013
Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. American journal of cardiovascular disease\| PubMed ID: 23785583	2013