Arminja N. Kettenbach Department of Biochemistry and Cell Biology Geisel School of Medicine at Dartmouth Biography Publications Institution JoVE Articles Arminja N. Kettenbach has not added a biography. If you are Arminja N. Kettenbach and would like to personalize this page please email our Author Liaison for assistance. Publications Myosin II Proteins Are Required for Organization of Calcium-induced Actin Networks Upstream of Mitochondrial Division Molecular Biology of the Cell. Apr, 2022 | Pubmed ID: 35427150 The Candida Albicans Cdk8-dependent Phosphoproteome Reveals Repression of Hyphal Growth Through a Flo8-dependent Pathway PLoS Genetics. 01, 2022 | Pubmed ID: 34982775 Regulation of PP2A, PP4, and PP6 Holoenzyme Assembly by Carboxyl-terminal Methylation Scientific Reports. 11, 2021 | Pubmed ID: 34845248 A Complex of BRCA2 and PP2A-B56 is Required for DNA Repair by Homologous Recombination Nature Communications. 09, 2021 | Pubmed ID: 34593815 Affinity-based Profiling of Endogenous Phosphoprotein Phosphatases by Mass Spectrometry Nature Protocols. 10, 2021 | Pubmed ID: 34518704 Selective Dephosphorylation by PP2A-B55 Directs the Meiosis I-meiosis II Transition in Oocytes ELife. 08, 2021 | Pubmed ID: 34342579 Use of Mitotic Protein Kinase Inhibitors and Phospho-Specific Antibodies to Monitor Protein Phosphorylation During the Cell Cycle Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34085225 Coupling of Cdc20 Inhibition and Activation by BubR1 The Journal of Cell Biology. 05, 2021 | Pubmed ID: 33819340 A Disorder-related Variant (E420K) of a PP2A-regulatory Subunit (PPP2R5D) Causes Constitutively Active AKT-mTOR Signaling and Uncoordinated Cell Growth The Journal of Biological Chemistry. Jan-Jun, 2021 | Pubmed ID: 33482199 Receptor-mediated Clustering of FIP200 Bypasses the Role of LC3 Lipidation in Autophagy The EMBO Journal. 12, 2020 | Pubmed ID: 33226137 Effects of Carboxyl-terminal Methylation on Holoenzyme Function of the PP2A Subfamily Biochemical Society Transactions. 10, 2020 | Pubmed ID: 33125487 Quantitative Kinase and Phosphatase Profiling Reveal That CDK1 Phosphorylates PP2Ac to Promote Mitotic Entry Science Signaling. 09, 2020 | Pubmed ID: 32900880 Fission Yeast Pak1 Phosphorylates Anillin-like Mid1 for Spatial Control of Cytokinesis The Journal of Cell Biology. 08, 2020 | Pubmed ID: 32421151 Mechanisms of Site-specific Dephosphorylation and Kinase Opposition Imposed by PP2A Regulatory Subunits The EMBO Journal. 07, 2020 | Pubmed ID: 32400009 A Dynamic Charge-charge Interaction Modulates PP2A:B56 Substrate Recruitment ELife. 03, 2020 | Pubmed ID: 32195664 Identification, Quantification and Bioinformatic Analysis of RNA-dependent Proteins by RNase Treatment and Density Gradient Ultracentrifugation Using R-DeeP Nature Protocols. 04, 2020 | Pubmed ID: 32094787 A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 01, 2020 | Pubmed ID: 31558472 A Mechanism for How Cdr1/Nim1 Kinase Promotes Mitotic Entry by Inhibiting Wee1 Molecular Biology of the Cell. 12, 2019 | Pubmed ID: 31644361 Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates ACS Chemical Biology. 12, 2019 | Pubmed ID: 31633908 A Consensus Binding Motif for the PP4 Protein Phosphatase Molecular Cell. 12, 2019 | Pubmed ID: 31585692 Estrogen Therapy Induces an Unfolded Protein Response to Drive Cell Death in ER+ Breast Cancer Molecular Oncology. 08, 2019 | Pubmed ID: 31180176 R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation Molecular Cell. 07, 2019 | Pubmed ID: 31076284 A Complex Containing Lysine-acetylated Actin Inhibits the Formin INF2 Nature Cell Biology. 05, 2019 | Pubmed ID: 30962575 The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora Molecular Cell. 05, 2019 | Pubmed ID: 30954403 Identification of the Substrate Recruitment Mechanism of the Muscle Glycogen Protein Phosphatase 1 Holoenzyme Science Advances. 11, 2018 | Pubmed ID: 30443599 A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans Molecular & Cellular Proteomics : MCP. 12, 2018 | Pubmed ID: 30228194 Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species Scientific Reports. Jun, 2018 | Pubmed ID: 29934597 Aurora B Opposes PP1 Function in Mitosis by Phosphorylating the Conserved PP1-binding RVxF Motif in PP1 Regulatory Proteins Science Signaling. 05, 2018 | Pubmed ID: 29764992 Global Assessment of Its Network Dynamics Reveals That the Kinase Plk1 Inhibits the Phosphatase PP6 to Promote Aurora A Activity Science Signaling. 05, 2018 | Pubmed ID: 29764989 Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis Frontiers in Cell and Developmental Biology. 2018 | Pubmed ID: 29623276 Therapeutically Targeting Tumor Microenvironment-mediated Drug Resistance in Estrogen Receptor-positive Breast Cancer The Journal of Experimental Medicine. 03, 2018 | Pubmed ID: 29436393 Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division Current Biology : CB. 01, 2018 | Pubmed ID: 29249658 Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics Frontiers in Cell and Developmental Biology. 2017 | Pubmed ID: 29214152 PP1:Tautomycetin Complex Reveals a Path Toward the Development of PP1-Specific Inhibitors Journal of the American Chemical Society. 12, 2017 | Pubmed ID: 29156132 Cyclin A/Cdk1 Modulates Plk1 Activity in Prometaphase to Regulate Kinetochore-microtubule Attachment Stability ELife. 11, 2017 | Pubmed ID: 29154753 Immunogenicity and Structures of a Rationally Designed Prefusion MERS-CoV Spike Antigen Proceedings of the National Academy of Sciences of the United States of America. 08, 2017 | Pubmed ID: 28807998 A Bifurcated Signaling Cascade of NIMA-related Kinases Controls Distinct Kinesins in Anaphase The Journal of Cell Biology. 08, 2017 | Pubmed ID: 28630147 HOPS Catalyzes the Interdependent Assembly of Each Vacuolar SNARE into a SNARE Complex Molecular Biology of the Cell. Apr, 2017 | Pubmed ID: 28148647 Identification of Candidate Cyclin-dependent Kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics Molecular & Cellular Proteomics : MCP. 07, 2016 | Pubmed ID: 27134283 Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells Stem Cells (Dayton, Ohio). 05, 2016 | Pubmed ID: 26756672 Quantitative Phosphoproteomics Reveals New Roles for the Protein Phosphatase PP6 in Mitotic Cells Science Signaling. Oct, 2015 | Pubmed ID: 26462736 Quantitative Phosphoproteomics Reveals Pathways for Coordination of Cell Growth and Division by the Conserved Fission Yeast Kinase Pom1 Molecular & Cellular Proteomics : MCP. May, 2015 | Pubmed ID: 25720772 SPECHT - Single-stage Phosphopeptide Enrichment and Stable-isotope Chemical Tagging: Quantitative Phosphoproteomics of Insulin Action in Muscle Journal of Proteomics. Jan, 2015 | Pubmed ID: 25463755 Yeast Vacuolar HOPS, Regulated by Its Kinase, Exploits Affinities for Acidic Lipids and Rab:GTP for Membrane Binding and to Catalyze Tethering and Fusion Molecular Biology of the Cell. Jan, 2015 | Pubmed ID: 25411340 Dueling Kinases Regulate Cell Size at Division Through the SAD Kinase Cdr2 Current Biology : CB. Feb, 2014 | Pubmed ID: 24508166 Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition Structure (London, England : 1993). Jun, 2013 | Pubmed ID: 23665168 Plk1 Regulates the Kinesin-13 Protein Kif2b to Promote Faithful Chromosome Segregation Molecular Biology of the Cell. Jun, 2012 | Pubmed ID: 22535524 A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors Kali A. Smolen1, Arminja N. Kettenbach1,2 1Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 2Norris Cotton Cancer Center JoVE 63805 Biochemistry
A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors Kali A. Smolen1, Arminja N. Kettenbach1,2 1Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 2Norris Cotton Cancer Center JoVE 63805 Biochemistry