Luis M. de la Maza Department of Pathology and Laboratory Medicine University of California Biography Publications Institution JoVE Articles Luis M. de la Maza has not added a biography. If you are Luis M. de la Maza and would like to personalize this page please email our Author Liaison for assistance. Publications A Survey of Preclinical Studies Evaluating Nanoparticle-Based Vaccines Against Non-Viral Sexually Transmitted Infections Frontiers in Pharmacology. 2021 | Pubmed ID: 34899322 Induction of Protection in Mice Against a Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in Nanolipoprotein Particles Vaccines. Jul, 2021 | Pubmed ID: 34358171 A Primary Chlamydia Trachomatis Genital Infection of Rhesus Macaques Identifies New Immunodominant B-cell Antigens PloS One. 2021 | Pubmed ID: 33886668 Vaccines for Genital Infections: Where Are We and How Far is There to Go? Expert Review of Vaccines. 04, 2021 | Pubmed ID: 33682583 Vaccination with the Recombinant Major Outer Membrane Protein Elicits Long-term Protection in Mice Against Vaginal Shedding and Infertility Following a Genital Challenge NPJ Vaccines. 2020 | Pubmed ID: 33083025 Induction of Protection in Mice Against a Respiratory Challenge by a Vaccine Formulated with Exosomes Isolated from Infected Cells NPJ Vaccines. 2020 | Pubmed ID: 33014435 Protection Against a Chlamydial Respiratory Challenge by a Chimeric Vaccine Formulated with the Major Outer Membrane Protein Variable Domains Using the Porin B As a Scaffold NPJ Vaccines. 2020 | Pubmed ID: 32411400 Improved Protection Against Chlamydia Muridarum Using the Native Major Outer Membrane Protein Trapped in Resiquimod-carrying Amphipols and Effects in Protection with Addition of a Th1 (CpG-1826) and a Th2 (Montanide ISA 720) Adjuvant Vaccine. 06, 2020 | Pubmed ID: 32386746 Protection of Outbred Mice Against a Vaginal Challenge by a Serovar E Recombinant Major Outer Membrane Protein Vaccine is Dependent on Phosphate Substitution in the Adjuvant Human Vaccines & Immunotherapeutics. 10, 2020 | Pubmed ID: 32118511 A Recombinant Chlamydia Trachomatis MOMP Vaccine Elicits Cross-serogroup Protection in Mice Against Vaginal Shedding and Infertility The Journal of Infectious Diseases. 01, 2020 | Pubmed ID: 31504647 Characterization of the Horizontal and Vertical Sexual Transmission of Genital Infections in a New Mouse Model Infection and Immunity. 07, 2019 | Pubmed ID: 30833332 National Institute of Allergy and Infectious Diseases Workshop Report: "Chlamydia Vaccines: The Way Forward" Vaccine. 11, 2019 | Pubmed ID: 29097007 Co-delivery of Amphipol-conjugated Adjuvant with Antigen, and Adjuvant Combinations, Enhance Immune Protection Elicited by a Membrane Protein-based Vaccine Against a Mucosal Challenge with Chlamydia Vaccine. 10, 2018 | Pubmed ID: 30293763 Transcervical Inoculation with Chlamydia Trachomatis Induces Infertility in HLA-DR4 Transgenic and Wild-Type Mice Infection and Immunity. 01, 2018 | Pubmed ID: 29038126 Genome-wide Profiling of Humoral Immunity and Pathogen Genes Under Selection Identifies Immune Evasion Tactics of Chlamydia Trachomatis During Ocular Infection Scientific Reports. 08, 2017 | Pubmed ID: 28851925 Comparison of the Nine Polymorphic Membrane Proteins of Chlamydia Trachomatis for Their Ability to Induce Protective Immune Responses in Mice Against a C. Muridarum Challenge Vaccine. 05, 2017 | Pubmed ID: 28385608 The Cationic Liposomal Adjuvants CAF01 and CAF09 Formulated with the Major Outer Membrane Protein Elicit Robust Protection in Mice Against a Chlamydia Muridarum Respiratory Challenge Vaccine. 03, 2017 | Pubmed ID: 28238632 Update on Chlamydia Trachomatis Vaccinology Clinical and Vaccine Immunology : CVI. Apr, 2017 | Pubmed ID: 28228394 Phosphate Substitution in an AlOOH - TLR4 Adjuvant System (SPA08) Modulates the Immunogenicity of Serovar E MOMP from Chlamydia Trachomatis Human Vaccines & Immunotherapeutics. 09, 2016 | Pubmed ID: 27104338 Computational Modeling of TC0583 As a Putative Component of the Chlamydia Muridarum V-type ATP Synthase Complex and Assessment of Its Protective Capabilities As a Vaccine Antigen Microbes and Infection. Apr, 2016 | Pubmed ID: 26706820 A Vaccine Formulated with the Major Outer Membrane Protein Can Protect C3H/HeN, a Highly Susceptible Strain of Mice, from a Chlamydia Muridarum Genital Challenge Immunology. Nov, 2015 | Pubmed ID: 26423798 Long-term Stability of a Vaccine Formulated with the Amphipol-trapped Major Outer Membrane Protein from Chlamydia Trachomatis The Journal of Membrane Biology. Oct, 2014 | Pubmed ID: 24942817 Whole Genome Identification of C. Trachomatis Immunodominant Antigens After Genital Tract Infections and Effect of Antibiotic Treatment of Pigtailed Macaques Journal of Proteomics. Aug, 2014 | Pubmed ID: 24862987 Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited Against a Vaginal Challenge with Chlamydia Muridarum Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24778450 TRAIL-R1 is a Negative Regulator of Pro-inflammatory Responses and Modulates Long-term Sequelae Resulting from Chlamydia Trachomatis Infections in Humans PloS One. 2014 | Pubmed ID: 24695582 A Vaccine Formulated with a Combination of TLR-2 and TLR-9 Adjuvants and the Recombinant Major Outer Membrane Protein Elicits a Robust Immune Response and Significant Protection Against a Chlamydia Muridarum Challenge Microbes and Infection. Mar, 2014 | Pubmed ID: 24291713 Assessment of the Role in Protection and Pathogenesis of the Chlamydia Muridarum V-type ATP Synthase Subunit A (AtpA) (TC0582) Microbes and Infection. Feb, 2014 | Pubmed ID: 24161793 Vaccination with Major Outer Membrane Protein Proteosomes Elicits Protection in Mice Against a Chlamydia Respiratory Challenge Microbes and Infection. Nov, 2013 | Pubmed ID: 23999313 A 3-dimensional Trimeric β-barrel Model for Chlamydia MOMP Contains Conserved and Novel Elements of Gram-negative Bacterial Porins PloS One. 2013 | Pubmed ID: 23935908 Mechanism of T-cell Mediated Protection in Newborn Mice Against A Chlamydia Infection Microbes and Infection. Jul-Aug, 2013 | Pubmed ID: 23644176 Vaccination with the Recombinant Major Outer Membrane Protein Elicits Antibodies to the Constant Domains and Induces Cross-serovar Protection Against Intranasal Challenge with Chlamydia Trachomatis Infection and Immunity. May, 2013 | Pubmed ID: 23478318 Differences in Infectivity and Induction of Infertility: a Comparative Study of Chlamydia Trachomatis Strains in the Murine Model Microbes and Infection. Mar, 2013 | Pubmed ID: 23287699 A TLR2 Agonist is a More Effective Adjuvant for a Chlamydia Major Outer Membrane Protein Vaccine Than Ligands to Other TLR and NOD Receptors Vaccine. Sep, 2011 | Pubmed ID: 21742006 Induction of Protection Against Vaginal Shedding and Infertility by a Recombinant Chlamydia Vaccine Vaccine. Jul, 2011 | Pubmed ID: 21609745 Amphipols Stabilize the Chlamydia Major Outer Membrane Protein and Enhance Its Protective Ability As a Vaccine Vaccine. Jun, 2011 | Pubmed ID: 21550371 Immunogenicity of a Vaccine Formulated with the Chlamydia Trachomatis Serovar F, Native Major Outer Membrane Protein in a Nonhuman Primate Model Vaccine. Apr, 2011 | Pubmed ID: 21376796 Induction of Protection in Mice Against a Respiratory Challenge by a Vaccine Formulated with the Chlamydia Major Outer Membrane Protein Adjuvanted with IC31® Vaccine. Mar, 2011 | Pubmed ID: 21276442 Identification of Immunodominant Antigens by Probing a Whole Chlamydia Trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice Infection and Immunity. Jan, 2011 | Pubmed ID: 20956570 A New Murine Model for Testing Vaccines Against Genital Chlamydia Trachomatis Infections in Males Vaccine. Nov, 2010 | Pubmed ID: 20920574 Enhancement of the Protective Efficacy of a Chlamydia Trachomatis Recombinant Vaccine by Combining Systemic and Mucosal Routes for Immunization Vaccine. Nov, 2010 | Pubmed ID: 20875490 Candidate Vaginal Microbicides with Activity Against Chlamydia Trachomatis and Neisseriagonorrhoeae International Journal of Antimicrobial Agents. Aug, 2010 | Pubmed ID: 20605703 Maternal Immunity Partially Protects Newborn Mice Against a Chlamydia Trachomatis Intranasal Challenge Journal of Reproductive Immunology. Nov, 2010 | Pubmed ID: 20554327 C3H Male Mice with Severe Combined Immunodeficiency Cannot Clear a Urethral Infection with a Human Serovar of Chlamydia Trachomatis Infection and Immunity. Dec, 2009 | Pubmed ID: 19805533 Induction of Protective Immunity by Vaccination Against Chlamydia Trachomatis Using the Major Outer Membrane Protein Adjuvanted with CpG Oligodeoxynucleotide Coupled to the Nontoxic B Subunit of Cholera Toxin Vaccine. Oct, 2009 | Pubmed ID: 19686693 Protection Against an Intranasal Challenge by Vaccines Formulated with Native and Recombinant Preparations of the Chlamydia Trachomatis Major Outer Membrane Protein Vaccine. Aug, 2009 | Pubmed ID: 19446590 Imaging of Effector Memory T Cells During a Delayed-type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block Immunity. Oct, 2008 | Pubmed ID: 18835197 Protection of Wild-type and Severe Combined Immunodeficiency Mice Against an Intranasal Challenge by Passive Immunization with Monoclonal Antibodies to the Chlamydia Trachomatis Mouse Pneumonitis Major Outer Membrane Protein Infection and Immunity. Dec, 2008 | Pubmed ID: 18809664 Structural and Functional Analyses of the Major Outer Membrane Protein of Chlamydia Trachomatis Journal of Bacteriology. Sep, 2007 | Pubmed ID: 17601785 Reversal of the Antichlamydial Activity of Putative Type III Secretion Inhibitors by Iron Infection and Immunity. Jul, 2007 | Pubmed ID: 17470544 Role of Matrix Metalloproteinase-7 in the Modulation of a Chlamydia Trachomatis Infection Immunology. Feb, 2006 | Pubmed ID: 16423057 Immunization with the Chlamydia Trachomatis Major Outer Membrane Protein, Using Adjuvants Developed for Human Vaccines, Can Induce Partial Protection in a Mouse Model Against a Genital Challenge Vaccine. Feb, 2006 | Pubmed ID: 16199110 Vaccination with the Chlamydia Trachomatis Major Outer Membrane Protein Can Elicit an Immune Response As Protective As That Resulting from Inoculation with Live Bacteria Infection and Immunity. Dec, 2005 | Pubmed ID: 16299310 Vaccination of Newborn Mice Induces a Strong Protective Immune Response Against Respiratory and Genital Challenges with Chlamydia Trachomatis Vaccine. Nov, 2005 | Pubmed ID: 16085340 Interaction Between Components of the Type III Secretion System of Chlamydiaceae Journal of Bacteriology. Jan, 2005 | Pubmed ID: 15629918 New Murine Model for the Study of Chlamydia Trachomatis Genitourinary Tract Infections in Males Infection and Immunity. Jul, 2004 | Pubmed ID: 15213165 Induction of Protective Immunity Against a Chlamydia Trachomatis Genital Infection in Three Genetically Distinct Strains of Mice Immunology. Nov, 2003 | Pubmed ID: 14632665 Temporal Expression of Type III Secretion Genes of Chlamydia Pneumoniae Infection and Immunity. May, 2003 | Pubmed ID: 12704128 Immunization with the Chlamydia Trachomatis Major Outer Membrane Protein, Using the Outer Surface Protein A of Borrelia Burgdorferi As an Adjuvant, Can Induce Protection Against a Chlamydial Genital Challenge Vaccine. Mar, 2003 | Pubmed ID: 12615442 Vaccines for Chlamydia Trachomatis Infections Current Opinion in Investigational Drugs (London, England : 2000). Jul, 2002 | Pubmed ID: 12186275 Immunization with the Chlamydia Trachomatis Mouse Pneumonitis Major Outer Membrane Protein by Use of CpG Oligodeoxynucleotides As an Adjuvant Induces a Protective Immune Response Against an Intranasal Chlamydial Challenge Infection and Immunity. Sep, 2002 | Pubmed ID: 12183524 Prediction of the Membrane-spanning Beta-strands of the Major Outer Membrane Protein of Chlamydia Protein Science : a Publication of the Protein Society. Jul, 2002 | Pubmed ID: 12070338 Inclusion Fluorescent-antibody Test As a Screening Assay for Detection of Antibodies to Chlamydia Pneumoniae Clinical and Diagnostic Laboratory Immunology. May, 2002 | Pubmed ID: 11986260 Comparison of Two Commercially Available Selective Media to Screen for Vancomycin-resistant Enterococci American Journal of Clinical Pathology. Jan, 2002 | Pubmed ID: 11789720 Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development Sean F. Gilmore*1, Wei He*1, Angela C. Evans1, Delia F. Tifrea2, Sukumar Pal2, Brent Segelke1, Sandra K. G. Peters1, B. Dillon Vannest1, Nicholas O. Fischer1, Amy Rasley1, Luis M. de la Maza2, Matthew A. Coleman1,3 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 2Department of Pathology and Laboratory Medicine, University of California, 3School of Medicine, Radiation Oncology, University of California Davis JoVE 63028 Immunology and Infection
Cell-Free Scaled Production and Adjuvant Addition to a Recombinant Major Outer Membrane Protein from Chlamydia muridarum for Vaccine Development Sean F. Gilmore*1, Wei He*1, Angela C. Evans1, Delia F. Tifrea2, Sukumar Pal2, Brent Segelke1, Sandra K. G. Peters1, B. Dillon Vannest1, Nicholas O. Fischer1, Amy Rasley1, Luis M. de la Maza2, Matthew A. Coleman1,3 1Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 2Department of Pathology and Laboratory Medicine, University of California, 3School of Medicine, Radiation Oncology, University of California Davis JoVE 63028 Immunology and Infection
