Thirumala-Devi Kanneganti

Publications

• CD47 Halts -deficient Neutrophils from Provoking Lethal Inflammation
  Science Advances. Jan, 2023  |   Pubmed ID: 36608128
• AIM2 Sensors Mediate Immunity to Infection in Hepatocytes
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2023  |   Pubmed ID: 36595704
• Inflammasome Signaling in Colorectal Cancer
  Translational Research : the Journal of Laboratory and Clinical Medicine. Feb, 2023  |   Pubmed ID: 36150688
• Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
  Pathogens (Basel, Switzerland). Nov, 2022  |   Pubmed ID: 36558734
• Determining Distinct Roles of IL-1α Through Generation of an IL-1α Knockout Mouse with No Defect in IL-1β Expression
  Frontiers in Immunology. 2022  |   Pubmed ID: 36505497
• Innate Immunity, Cytokine Storm, and Inflammatory Cell Death in COVID-19
  Journal of Translational Medicine. Nov, 2022  |   Pubmed ID: 36419185
• Humans PIKK-up NLRP3 to Skip NEK7
  Trends in Immunology. Dec, 2022  |   Pubmed ID: 36404209
• Pancancer Transcriptomic Profiling Identifies Key PANoptosis Markers As Therapeutic Targets for Oncology
  NAR Cancer. Dec, 2022  |   Pubmed ID: 36329783
• PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2022  |   Pubmed ID: 36253067
• Molecular Mechanism of RIPK1 and Caspase-8 in Homeostatic Type I Interferon Production and Regulation
  Cell Reports. Oct, 2022  |   Pubmed ID: 36198273
• Single Cell Analysis of PANoptosome Cell Death Complexes Through an Expansion Microscopy Method
  Cellular and Molecular Life Sciences : CMLS. Sep, 2022  |   Pubmed ID: 36169732
• A BAF-fling Connection to RIPK1
  Cell Research. Aug, 2022  |   Pubmed ID: 35787662
• Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease
  Cells. Jun, 2022  |   Pubmed ID: 35741014
• DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease
  Cells. May, 2022  |   Pubmed ID: 35626643
• ZBP1-dependent Inflammatory Cell Death, PANoptosis, and Cytokine Storm Disrupt IFN Therapeutic Efficacy During Coronavirus Infection
  Science Immunology. Aug, 2022  |   Pubmed ID: 35587515
• It's All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects
  Cells. Apr, 2022  |   Pubmed ID: 35563804
• NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis
  ImmunoHorizons. Mar, 2022  |   Pubmed ID: 35301258
• The Transcription Factor IRF9 Promotes Colorectal Cancer Via Modulating the IL-6/STAT3 Signaling Axis
  Cancers. Feb, 2022  |   Pubmed ID: 35205671
• Innate Immunity: the First Line of Defense Against SARS-CoV-2
  Nature Immunology. Feb, 2022  |   Pubmed ID: 35105981
• Induces NLRP3 Inflammasome Activation and Caspase-8-mediated Apoptosis of Macrophages to Promote Lethal Anthrax
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2022  |   Pubmed ID: 34996874
• Fostering Experimental and Computational Synergy to Modulate Hyperinflammation
  Trends in Immunology. Jan, 2022  |   Pubmed ID: 34844849
• It's Just a Phase: NLRP6 Phase Separations Drive Signaling
  Cell Research. Feb, 2022  |   Pubmed ID: 34837058
• Integrated Stress Response Restricts Macrophage Necroptosis
  Life Science Alliance. Jan, 2022  |   Pubmed ID: 34764207
• The IFN-inducible GTPase IRGB10 Regulates Viral Replication and Inflammasome Activation During Influenza A Virus Infection in Mice
  European Journal of Immunology. Feb, 2022  |   Pubmed ID: 34694641
• Programming Inflammatory Cell Death for Therapy
  Pharmacology & Therapeutics. Apr, 2022  |   Pubmed ID: 34619283
• PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field
  Journal of Molecular Biology. Feb, 2022  |   Pubmed ID: 34537233
• Fungal Cell Wall Components Modulate Our Immune System
  Cell Surface (Amsterdam, Netherlands). Dec, 2021  |   Pubmed ID: 34825116
• Caspase-6 Promotes Activation of the Caspase-11-NLRP3 Inflammasome During Gram-negative Bacterial Infections
  The Journal of Biological Chemistry. Dec, 2021  |   Pubmed ID: 34740613
• ADAR1 Restricts ZBP1-mediated Immune Response and PANoptosis to Promote Tumorigenesis
  Cell Reports. Oct, 2021  |   Pubmed ID: 34686350
• NLRP3 Inflammasome Activation Triggers Gasdermin D-independent Inflammation
  Science Immunology. Oct, 2021  |   Pubmed ID: 34678046
• Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense During Influenza A Virus Infection
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2021  |   Pubmed ID: 34663620
• From Pyroptosis, Apoptosis and Necroptosis to PANoptosis: A Mechanistic Compendium of Programmed Cell Death Pathways
  Computational and Structural Biotechnology Journal. 2021  |   Pubmed ID: 34504660
• AIM2 Forms a Complex with Pyrin and ZBP1 to Drive PANoptosis and Host Defence
  Nature. Sep, 2021  |   Pubmed ID: 34471287
• Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth
  ImmunoHorizons. Jul, 2021  |   Pubmed ID: 34290111
• The 'cytokine Storm': Molecular Mechanisms and Therapeutic Prospects
  Trends in Immunology. Aug, 2021  |   Pubmed ID: 34217595
• Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia Thailandensis Pathogenesis
  MBio. Jun, 2021  |   Pubmed ID: 34154417
• TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2021  |   Pubmed ID: 34145059
• CovidExpress: an Interactive Portal for Intuitive Investigation on SARS-CoV-2 Related Transcriptomes
  BioRxiv : the Preprint Server for Biology. Aug, 2021  |   Pubmed ID: 34075382
• TLR2 Senses the SARS-CoV-2 Envelope Protein to Produce Inflammatory Cytokines
  Nature Immunology. Jul, 2021  |   Pubmed ID: 33963333
• Intestinal Tête-à-tête: Helminths Blunt Immunity Against Flaviviruses
  Cell Research. Jul, 2021  |   Pubmed ID: 33846568
• DDX3X Coordinates Host Defense Against Influenza Virus by Activating the NLRP3 Inflammasome and Type I Interferon Response
  The Journal of Biological Chemistry. 2021  |   Pubmed ID: 33766561
• Role of Inflammasomes/pyroptosis and PANoptosis During Fungal Infection
  PLoS Pathogens. Mar, 2021  |   Pubmed ID: 33735255
• NLRP3 Inflammasome in Cancer and Metabolic Diseases
  Nature Immunology. May, 2021  |   Pubmed ID: 33707781
• Sepsis Take-out: Inhibiting Bacterial Deliveries
  Immunity. Mar, 2021  |   Pubmed ID: 33691128
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)
  Autophagy. Feb, 2021  |   Pubmed ID: 33634751
• A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma
  Cancer Research. May, 2021  |   Pubmed ID: 33619117
• Metabolic Regulation of Pyroptotic Cell Death Expands the Therapeutic Landscape for Treating Inflammatory Disease
  Signal Transduction and Targeted Therapy. Jan, 2021  |   Pubmed ID: 33514689
• Advances in Understanding Activation and Function of the NLRC4 Inflammasome
  International Journal of Molecular Sciences. Jan, 2021  |   Pubmed ID: 33494299
• Osteoclast Fusion and Bone Loss Are Restricted by Interferon Inducible Guanylate Binding Proteins
  Nature Communications. Jan, 2021  |   Pubmed ID: 33479228
• Publisher Correction: Galactosaminogalactan Activates the Inflammasome to Provide Host Protection
  Nature. Jan, 2021  |   Pubmed ID: 33349706
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
  Cell. Jan, 2021  |   Pubmed ID: 33278357
• PANoptosis in Microbial Infection
  Current Opinion in Microbiology. Feb, 2021  |   Pubmed ID: 32829024
• Ets-2 Deletion in Myeloid Cells Attenuates IL-1α-mediated Inflammatory Disease Caused by a Ptpn6 Point Mutation
  Cellular & Molecular Immunology. Jul, 2021  |   Pubmed ID: 32203187
• Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense
  Journal of Cellular Immunology. 2020  |   Pubmed ID: 33426542
• RIPK1 Distinctly Regulates -Induced Inflammatory Cell Death, PANoptosis
  ImmunoHorizons. Dec, 2020  |   Pubmed ID: 33310881
• Galactosaminogalactan Activates the Inflammasome to Provide Host Protection
  Nature. Dec, 2020  |   Pubmed ID: 33268895
• The Innate Immune System and Cell Death in Autoinflammatory and Autoimmune Disease
  Current Opinion in Immunology. Dec, 2020  |   Pubmed ID: 33242752
• Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
  Trends in Immunology. Dec, 2020  |   Pubmed ID: 33153908
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
  BioRxiv : the Preprint Server for Biology. Nov, 2020  |   Pubmed ID: 33140051
• ZBP1 Promotes Fungi-induced Inflammasome Activation and Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
  The Journal of Biological Chemistry. Dec, 2020  |   Pubmed ID: 33109609
• RIPK3 Promotes Expression and Pyrin Inflammasome Activation Via Modulation of MTOR Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2020  |   Pubmed ID: 32989095
• Acute IL-4 Governs Pathogenic T Cell Responses During Infection
  ImmunoHorizons. Sep, 2020  |   Pubmed ID: 32948646
• Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles
  Trends in Molecular Medicine. Nov, 2020  |   Pubmed ID: 32948447
• A Comprehensive Guide to Studying Inflammasome Activation and Cell Death
  Nature Protocols. Oct, 2020  |   Pubmed ID: 32895525
• Intracellular Innate Immune Receptors: Life Inside the Cell
  Immunological Reviews. Sep, 2020  |   Pubmed ID: 32856334
• NLRP12 in Innate Immunity and Inflammation
  Molecular Aspects of Medicine. Dec, 2020  |   Pubmed ID: 32838963
• Impaired NLRP3 Inflammasome Activation/pyroptosis Leads to Robust Inflammatory Cell Death Via Caspase-8/RIPK3 During Coronavirus Infection
  The Journal of Biological Chemistry. Oct, 2020  |   Pubmed ID: 32763970
• The Regulation of the ZBP1-NLRP3 Inflammasome and Its Implications in Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
  Immunological Reviews. Sep, 2020  |   Pubmed ID: 32729116
• ZBP1: A STARGᐰTE to Decode the Biology of Z-nucleic Acids in Disease
  The Journal of Experimental Medicine. Jul, 2020  |   Pubmed ID: 32584411
• The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
  Frontiers in Cellular and Infection Microbiology. 2020  |   Pubmed ID: 32582562
• PANoptosis Components, Regulation, and Implications
  Aging. Jun, 2020  |   Pubmed ID: 32575071
• Interferon Regulatory Factor 1 Regulates PANoptosis to Prevent Colorectal Cancer
  JCI Insight. Jun, 2020  |   Pubmed ID: 32554929
• DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma
  Developmental Cell. Aug, 2020  |   Pubmed ID: 32553121
• Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
  Frontiers in Cellular and Infection Microbiology. 2020  |   Pubmed ID: 32547960
• Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis
  Immunity. Jun, 2020  |   Pubmed ID: 32428502
• DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells
  DNA and Cell Biology. Jul, 2020  |   Pubmed ID: 32397752
• The Zα2 Domain of ZBP1 is a Molecular Switch Regulating Influenza-induced PANoptosis and Perinatal Lethality During Development
  The Journal of Biological Chemistry. Jun, 2020  |   Pubmed ID: 32350114
• Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
  Cell. Apr, 2020  |   Pubmed ID: 32298652
• IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death
  Journal of Immunology (Baltimore, Md. : 1950). May, 2020  |   Pubmed ID: 32205422
• Toward Targeting Inflammasomes: Insights into Their Regulation and Activation
  Cell Research. Apr, 2020  |   Pubmed ID: 32152420
• Interferon Inducible GBPs Restrict Burkholderia Thailandensis motility Induced Cell-cell Fusion
  PLoS Pathogens. Mar, 2020  |   Pubmed ID: 32150572
• DNA Sensing in the Innate Immune Response
  Physiology (Bethesda, Md.). Mar, 2020  |   Pubmed ID: 32027562
• Caspases in Cell Death, Inflammation, and Pyroptosis
  Annual Review of Immunology. Apr, 2020  |   Pubmed ID: 32017655
• Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD
  Inflammation. Jun, 2020  |   Pubmed ID: 32002713
• Innate Immune Priming in the Absence of TAK1 Drives RIPK1 Kinase Activity-independent Pyroptosis, Apoptosis, Necroptosis, and Inflammatory Disease
  The Journal of Experimental Medicine. Mar, 2020  |   Pubmed ID: 31869420
• Inflammasomes and the Fine Line Between Defense and Disease
  Current Opinion in Immunology. Feb, 2020  |   Pubmed ID: 31837596
• The Nonreceptor Tyrosine Kinase SYK Drives Caspase-8/NLRP3 Inflammasome-mediated Autoinflammatory Osteomyelitis
  The Journal of Biological Chemistry. Mar, 2020  |   Pubmed ID: 31719149
• Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells
  Journal of Virology. Jan, 2020  |   Pubmed ID: 31694942
• Inflammasomes in the Pathophysiology of Autoinflammatory Syndromes
  Journal of Leukocyte Biology. Mar, 2020  |   Pubmed ID: 31608507
• Pyroptosis in Antiviral Immunity
  Current Topics in Microbiology and Immunology. Dec, 2019  |   Pubmed ID: 31875268
• ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)
  Frontiers in Cellular and Infection Microbiology. 2019  |   Pubmed ID: 31850239
• Targeting Apoptosis Inhibition to Activate Antitumor Immunity
  Trends in Immunology. Dec, 2019  |   Pubmed ID: 31735511
• Hidden Aspects of Valency in Immune System Regulation
  Trends in Immunology. Dec, 2019  |   Pubmed ID: 31734148
• DDX3X Acts As a Live-or-die Checkpoint in Stressed Cells by Regulating NLRP3 Inflammasome
  Nature. Sep, 2019  |   Pubmed ID: 31511697
• Role of AIM2 Inflammasome in Inflammatory Diseases, Cancer and Infection
  European Journal of Immunology. Nov, 2019  |   Pubmed ID: 31372985
• Cell Death-mediated Cytokine Release and Its Therapeutic Implications
  The Journal of Experimental Medicine. Jul, 2019  |   Pubmed ID: 31186281
• On the Road to Discovering the Elusive Executioner of Pyroptosis
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2019  |   Pubmed ID: 30885986
• Diverging Inflammasome Signals in Tumorigenesis and Potential Targeting
  Nature Reviews. Cancer. Apr, 2019  |   Pubmed ID: 30842595
• Enhanced IL-1β Production is Mediated by a TLR2-MYD88-NLRP3 Signaling Axis During Coinfection with Influenza A Virus and Streptococcus Pneumoniae
  PloS One. 2019  |   Pubmed ID: 30794604
• Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
  Cell Reports. Jan, 2019  |   Pubmed ID: 30673616
• Fueling Ketone Metabolism Quenches Salt-Induced Hypertension
  Trends in Endocrinology and Metabolism: TEM. Mar, 2019  |   Pubmed ID: 30670332
• Differential Role of the NLRP3 Inflammasome in Infection and Tumorigenesis
  Immunology. Apr, 2019  |   Pubmed ID: 30666624
• Sterile Particle-induced Inflammation is Mediated by Macrophages Releasing IL-33 Through a Bruton's Tyrosine Kinase-dependent Pathway
  Nature Materials. Mar, 2019  |   Pubmed ID: 30664693
• The Signposts and Winding Roads to Immunity and Inflammation
  Nature Reviews. Immunology. Feb, 2019  |   Pubmed ID: 30602731
• Fungal Ligands Released by Innate Immune Effectors Promote Inflammasome Activation During Aspergillus Fumigatus Infection
  Nature Microbiology. Feb, 2019  |   Pubmed ID: 30510167
• TNF/TNFR Axis Promotes Pyrin Inflammasome Activation and Distinctly Modulates Pyrin Inflammasomopathy
  The Journal of Clinical Investigation. Jan, 2019  |   Pubmed ID: 30457980
• Innate Immune Adaptor MyD88 Deficiency Prevents Skin Inflammation in SHARPIN-deficient Mice
  Cell Death and Differentiation. Mar, 2019  |   Pubmed ID: 30038386
• The NLRC4 Inflammasome Requires IRF8-dependent Production of NAIPs
  Cell Stress. May, 2018  |   Pubmed ID: 31225480
• Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease?
  Circulation. Dec, 2018  |   Pubmed ID: 30571276
• Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection Against
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2018  |   Pubmed ID: 30404813
• Gasdermin D Mediates the Pathogenesis of Neonatal-onset Multisystem Inflammatory Disease in Mice
  PLoS Biology. Nov, 2018  |   Pubmed ID: 30388107
• SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer
  Immunity. Sep, 2018  |   Pubmed ID: 30231985
• Lung γδ T Cells Mediate Protective Responses During Neonatal Influenza Infection That Are Associated with Type 2 Immunity
  Immunity. Sep, 2018  |   Pubmed ID: 30170813
• Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2018  |   Pubmed ID: 30082320
• Guanylate Binding Proteins Facilitate Caspase-11-dependent Pyroptosis in Response to Type 3 Secretion System-negative
  Cell Death Discovery. 2018  |   Pubmed ID: 30062052
• Genetic Deficiency of NOD2 Confers Resistance to Invasive Aspergillosis
  Nature Communications. Jul, 2018  |   Pubmed ID: 29980664
• The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
  Immunity. Jul, 2018  |   Pubmed ID: 29958799
• The Inflammasome Starts Rolling
  Nature Reviews. Immunology. Aug, 2018  |   Pubmed ID: 29858587
• ASK1/2 Signaling Promotes Inflammation in a Mouse Model of Neutrophilic Dermatosis
  The Journal of Clinical Investigation. May, 2018  |   Pubmed ID: 29629899
• IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation
  Cell. May, 2018  |   Pubmed ID: 29576451
• Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses During Francisella Novicida Infection
  Cell Reports. Mar, 2018  |   Pubmed ID: 29562174
• Food for Training-Western Diet and Inflammatory Memory
  Cell Metabolism. Mar, 2018  |   Pubmed ID: 29514058
• TAK1 Restricts Spontaneous NLRP3 Activation and Cell Death to Control Myeloid Proliferation
  The Journal of Experimental Medicine. Apr, 2018  |   Pubmed ID: 29500178
• ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming
  The American Journal of Pathology. Apr, 2018  |   Pubmed ID: 29353059
• Stressed-out ROS Take a Silent Death Route
  Nature Immunology. Feb, 2018  |   Pubmed ID: 29348507
• Gasdermin D Flashes an Exit Signal for IL-1
  Immunity. Jan, 2018  |   Pubmed ID: 29343431
• IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death During Influenza Virus Infection
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2018  |   Pubmed ID: 29321274
• Function and Regulation of IL-1α in Inflammatory Diseases and Cancer
  Immunological Reviews. Jan, 2018  |   Pubmed ID: 29247991
• Mechanisms and Consequences of Inflammasome Activation
  Journal of Molecular Biology. Jan, 2018  |   Pubmed ID: 29247654
• ZBP1: Innate Sensor Regulating Cell Death and Inflammation
  Trends in Immunology. Feb, 2018  |   Pubmed ID: 29236673
• Triggers a CGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2018  |   Pubmed ID: 29203515
• Pyrin Inflammasome Regulates Tight Junction Integrity To Restrict Colitis and Tumorigenesis
  Gastroenterology. Mar, 2018  |   Pubmed ID: 29203393
• Recent Advances in Inflammasome Biology
  Current Opinion in Immunology. Feb, 2018  |   Pubmed ID: 29128729
• The Absence of NOD1 Enhances Killing of Through Modulation of Dectin-1 Expression
  Frontiers in Immunology. 2017  |   Pubmed ID: 29326692
• Caspase-1 Engagement and TLR-Induced C-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4
  Cell Reports. Dec, 2017  |   Pubmed ID: 29262324
• Inflammasome Activation and Assembly at a Glance
  Journal of Cell Science. Dec, 2017  |   Pubmed ID: 29196474
• CGAMP: A Tale of Two Signals
  The Journal of Experimental Medicine. Dec, 2017  |   Pubmed ID: 29150429
• Inflammatory Cell Death in Intestinal Pathologies
  Immunological Reviews. Nov, 2017  |   Pubmed ID: 29027223
• Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins
  MBio. Oct, 2017  |   Pubmed ID: 28974614
• Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC Via the CGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2017  |   Pubmed ID: 28947539
• Toll-like Receptor 2 Induced Cytotoxic T-lymphocyte-associated Protein 4 Regulates Aspergillus-induced Regulatory T-cells with Pro-inflammatory Characteristics
  Scientific Reports. Sep, 2017  |   Pubmed ID: 28904353
• Inflammatory Bowel Disease and the NLRP3 Inflammasome
  The New England Journal of Medicine. Aug, 2017  |   Pubmed ID: 28813221
• Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components
  Infection and Immunity. Oct, 2017  |   Pubmed ID: 28784930
• War on Viruses: LC3 Recruits GTPases
  Cell Host & Microbe. Jul, 2017  |   Pubmed ID: 28704655
• ZBP1/DAI Ubiquitination and Sensing of Influenza VRNPs Activate Programmed Cell Death
  The Journal of Experimental Medicine. Aug, 2017  |   Pubmed ID: 28634194
• Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance
  Journal of Virology. Sep, 2017  |   Pubmed ID: 28615208
• NLRC3 Regulates Cellular Proliferation and Apoptosis to Attenuate the Development of Colorectal Cancer
  Cell Cycle (Georgetown, Tex.). Jul, 2017  |   Pubmed ID: 28598238
• Mechanisms Governing Inflammasome Activation, Assembly and Pyroptosis Induction
  International Immunology. May, 2017  |   Pubmed ID: 28531279
• Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2017  |   Pubmed ID: 28468974
• Molecular Mechanisms and Functions of Pyroptosis, Inflammatory Caspases and Inflammasomes in Infectious Diseases
  Immunological Reviews. May, 2017  |   Pubmed ID: 28462526
• Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease
  Immunity. Apr, 2017  |   Pubmed ID: 28410990
• Inflammasome Activation by Nucleic Acids and Nucleosomes in Sterile Inflammation… or is It Sterile?
  The FEBS Journal. Aug, 2017  |   Pubmed ID: 28374568
• Differential Roles of Caspase-1 and Caspase-11 in Infection and Inflammation
  Scientific Reports. Mar, 2017  |   Pubmed ID: 28345580
• Regulation and Functions of NLRP3 Inflammasome During Influenza Virus Infection
  Molecular Immunology. Jun, 2017  |   Pubmed ID: 28169000
• Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2017  |   Pubmed ID: 28130494
• Inflammasomes and Cancer
  Cancer Immunology Research. Feb, 2017  |   Pubmed ID: 28093447
• IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever
  The American Journal of Pathology. Feb, 2017  |   Pubmed ID: 27998728
• Interferon-inducible Guanylate-binding Proteins at the Interface of Cell-autonomous Immunity and Inflammasome Activation
  Journal of Leukocyte Biology. Jan, 2017  |   Pubmed ID: 27418355
• Critical Role of Caspase-8-mediated IL-1 Signaling in Promoting Th2 Responses During Asthma Pathogenesis
  Mucosal Immunology. 01, 2017  |   Pubmed ID: 27007676
• NLRC3 is an Inhibitory Sensor of PI3K-mTOR Pathways in Cancer
  Nature. Dec, 2016  |   Pubmed ID: 27951586
• ZBP1/DAI is an Innate Sensor of Influenza Virus Triggering the NLRP3 Inflammasome and Programmed Cell Death Pathways
  Science Immunology. Aug, 2016  |   Pubmed ID: 27917412
• Distinct Role of IL-1β in Instigating Disease in Sharpin Mice
  Scientific Reports. Nov, 2016  |   Pubmed ID: 27892465
• Regulation of Lysosomal Dynamics and Autophagy by CTSB/cathepsin B
  Autophagy. Dec, 2016  |   Pubmed ID: 27786577
• IL-33 Regulates the IgA-microbiota Axis to Restrain IL-1α-dependent Colitis and Tumorigenesis
  The Journal of Clinical Investigation. Dec, 2016  |   Pubmed ID: 27775548
• IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes
  Cell. Oct, 2016  |   Pubmed ID: 27693356
• Rewiring Cellular Metabolism Via the AKT/mTOR Pathway Contributes to Host Defence Against Mycobacterium Tuberculosis in Human and Murine Cells
  European Journal of Immunology. Nov, 2016  |   Pubmed ID: 27624090
• Cathepsin B Modulates Lysosomal Biogenesis and Host Defense Against Francisella Novicida Infection
  The Journal of Experimental Medicine. Sep, 2016  |   Pubmed ID: 27551156
• The Cell Biology of Inflammasomes: Mechanisms of Inflammasome Activation and Regulation
  The Journal of Cell Biology. Jun, 2016  |   Pubmed ID: 27325789
• DOCK2 Confers Immunity and Intestinal Colonization Resistance to Citrobacter Rodentium Infection
  Scientific Reports. Jun, 2016  |   Pubmed ID: 27291827
• Autoinflammatory Skin Disorders: The Inflammasomme in Focus
  Trends in Molecular Medicine. Jul, 2016  |   Pubmed ID: 27267764
• Microbiota and Caspase-1/caspase-8 Regulate IL-1β-mediated Bone Disease
  Gut Microbes. Jul, 2016  |   Pubmed ID: 27148834
• Autophagy Suppresses Host Adaptive Immune Responses Toward Borrelia Burgdorferi
  Journal of Leukocyte Biology. Sep, 2016  |   Pubmed ID: 27101991
• NLRP3 Inflammasome Plays a Redundant Role with Caspase 8 to Promote IL-1β-mediated Osteomyelitis
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016  |   Pubmed ID: 27071119
• DNA-sensing Inflammasomes: Regulation of Bacterial Host Defense and the Gut Microbiota
  Pathogens and Disease. Jun, 2016  |   Pubmed ID: 27056948
• Immune Responses Against Protozoan Parasites: a Focus on the Emerging Role of Nod-like Receptors
  Cellular and Molecular Life Sciences : CMLS. Aug, 2016  |   Pubmed ID: 27032699
• Type I Interferon Keeps IL-1β in Check
  Cell Host & Microbe. Mar, 2016  |   Pubmed ID: 26962937
• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition)
  Autophagy. Jan, 2016  |   Pubmed ID: 26799652
• Converging Roles of Caspases in Inflammasome Activation, Cell Death and Innate Immunity
  Nature Reviews. Immunology. Jan, 2016  |   Pubmed ID: 26655628
• AIM2 Inflammasome in Infection, Cancer, and Autoimmunity: Role in DNA Sensing, Inflammation, and Innate Immunity
  European Journal of Immunology. Feb, 2016  |   Pubmed ID: 26626159
• Gasdermin D: the Long-awaited Executioner of Pyroptosis
  Cell Research. Nov, 2015  |   Pubmed ID: 26482951
• Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation Through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
  Scientific Reports. Sep, 2015  |   Pubmed ID: 26412089
• NLRP12 in Autoimmune Diseases
  Oncotarget. Aug, 2015  |   Pubmed ID: 26343520
• Innate Immunity Against Leishmania Infections
  Cellular Microbiology. Sep, 2015  |   Pubmed ID: 26249747
• Molecular Characterization of LC3-associated Phagocytosis Reveals Distinct Roles for Rubicon, NOX2 and Autophagy Proteins
  Nature Cell Biology. Jul, 2015  |   Pubmed ID: 26098576
• Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
  Cell. Jul, 2015  |   Pubmed ID: 26095253
• Innate Immune Recognition of MtDNA--an Undercover Signal?
  Cell Metabolism. Jun, 2015  |   Pubmed ID: 26039443
• A20 is a Regulator of Necroptosis
  Nature Immunology. Jun, 2015  |   Pubmed ID: 25988900
• NALP3 Inflammasome Upregulation and CASP1 Cleavage of the Glucocorticoid Receptor Cause Glucocorticoid Resistance in Leukemia Cells
  Nature Genetics. Jun, 2015  |   Pubmed ID: 25938942
• The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells
  Immunity. Apr, 2015  |   Pubmed ID: 25888258
• Regulation of Inflammasome Activation
  Immunological Reviews. May, 2015  |   Pubmed ID: 25879280
• The Inflammasome: Firing Up Innate Immunity
  Immunological Reviews. May, 2015  |   Pubmed ID: 25879279
• The Transcription Factor IRF1 and Guanylate-binding Proteins Target Activation of the AIM2 Inflammasome by Francisella Infection
  Nature Immunology. May, 2015  |   Pubmed ID: 25774715
• Inflammasome Control of Viral Infection
  Current Opinion in Virology. Jun, 2015  |   Pubmed ID: 25771504
• Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection Against Aspergillus Infection
  Cell Host & Microbe. Mar, 2015  |   Pubmed ID: 25704009
• An NLRP3 Inflammasome-triggered Th2-biased Adaptive Immune Response Promotes Leishmaniasis
  The Journal of Clinical Investigation. Mar, 2015  |   Pubmed ID: 25689249
• Cutting Edge: SHARPIN is Required for Optimal NLRP3 Inflammasome Activation
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2015  |   Pubmed ID: 25637014
• IL-10 Engages Macrophages to Shift Th17 Cytokine Dependency and Pathogenicity During T-cell-mediated Colitis
  Nature Communications. Jan, 2015  |   Pubmed ID: 25607885
• MHCII-independent CD4+ T Cells Protect Injured CNS Neurons Via IL-4
  The Journal of Clinical Investigation. Feb, 2015  |   Pubmed ID: 25607842
• Flagellin-induced NLRC4 Phosphorylation Primes the Inflammasome for Activation by NAIP5
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2015  |   Pubmed ID: 25605939
• Drak2 is Not Required for Tumor Surveillance and Suppression
  International Immunology. Mar, 2015  |   Pubmed ID: 25568303
• Mitochondria: Diversity in the Regulation of the NLRP3 Inflammasome
  Trends in Molecular Medicine. Mar, 2015  |   Pubmed ID: 25500014
• Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
  The American Journal of Pathology. Jan, 2015  |   Pubmed ID: 25451151
• Cutting Edge: STING Mediates Protection Against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014  |   Pubmed ID: 25320273
• Dietary Modulation of the Microbiome Affects Autoinflammatory Disease
  Nature. Dec, 2014  |   Pubmed ID: 25274309
• Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome During Enteric Pathogen Infection
  PLoS Pathogens. Sep, 2014  |   Pubmed ID: 25254654
• Negative Regulation of the NLRP3 Inflammasome by A20 Protects Against Arthritis
  Nature. Aug, 2014  |   Pubmed ID: 25043000
• Nucleotide Oligomerization and Binding Domain 2-dependent Dendritic Cell Activation is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection
  Journal of Virology. Aug, 2014  |   Pubmed ID: 24872587
• Caspase-11 is Expressed in the Colonic Mucosa and Protects Against Dextran Sodium Sulfate-induced Colitis
  Mucosal Immunology. Nov, 2014  |   Pubmed ID: 24850431
• Beyond Canonical Inflammasomes: Emerging Pathways in IL-1-mediated Autoinflammatory Disease
  Seminars in Immunopathology. Sep, 2014  |   Pubmed ID: 24838628
• RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
  Cell. May, 2014  |   Pubmed ID: 24813850
• Fungal Chitin Dampens Inflammation Through IL-10 Induction Mediated by NOD2 and TLR9 Activation
  PLoS Pathogens. Apr, 2014  |   Pubmed ID: 24722226
• Activation of the NLRP1b Inflammasome Independently of ASC-mediated Caspase-1 Autoproteolysis and Speck Formation
  Nature Communications. 2014  |   Pubmed ID: 24492532
• FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2014  |   Pubmed ID: 24453255
• Critical Role for Inflammasome-independent IL-1β Production in Osteomyelitis
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014  |   Pubmed ID: 24395792
• Salmonella Exploits NLRP12-dependent Innate Immune Signaling to Suppress Host Defenses During Infection
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014  |   Pubmed ID: 24347638
• Role of Type I Interferons in Inflammasome Activation, Cell Death, and Disease During Microbial Infection
  Frontiers in Cellular and Infection Microbiology. 2013  |   Pubmed ID: 24273750
• Unsolved Mysteries in NLR Biology
  Frontiers in Immunology. Sep, 2013  |   Pubmed ID: 24062750
• The Expanding Role of NLRs in Antiviral Immunity
  Immunological Reviews. Sep, 2013  |   Pubmed ID: 23947344
• NLRP6 in Infection and Inflammation
  Microbes and Infection. 2013  |   Pubmed ID: 23811097
• RIP1-driven Autoinflammation Targets IL-1α Independently of Inflammasomes and RIP3
  Nature. Jun, 2013  |   Pubmed ID: 23708968
• Receptor Interacting Protein Kinase 2-mediated Mitophagy Regulates Inflammasome Activation During Virus Infection
  Nature Immunology. May, 2013  |   Pubmed ID: 23525089
• Autophagy Modulates Borrelia Burgdorferi-induced Production of Interleukin-1β (IL-1β)
  The Journal of Biological Chemistry. Mar, 2013  |   Pubmed ID: 23386602
• Innate Immune Pathways in Host Defense
  Mediators of Inflammation. 2012  |   Pubmed ID: 23326019
• Murine Borrelia Arthritis is Highly Dependent on ASC and Caspase-1, but Independent of NLRP3
  Arthritis Research & Therapy. Nov, 2012  |   Pubmed ID: 23148704
• IL-1 Family Cytokines Trigger Sterile Inflammatory Disease
  Frontiers in Immunology. 2012  |   Pubmed ID: 23087690
• Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens
  The Journal of Biological Chemistry. Oct, 2012  |   Pubmed ID: 22898816
• Membrane Damage During Listeria Monocytogenes Infection Triggers a Caspase-7 Dependent Cytoprotective Response
  PLoS Pathogens. 2012  |   Pubmed ID: 22807671
• NLRP6 Negatively Regulates Innate Immunity and Host Defence Against Bacterial Pathogens
  Nature. Aug, 2012  |   Pubmed ID: 22763455
• The Role of Inflammasome Modulation in Virulence
  Virulence. May, 2012  |   Pubmed ID: 22546900