Autoimmune Pancreatitis
Autoimmune Pancreatitis - Related Videos
10:38
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
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Cited by 4 •
2010
This video shows how to induce autoimmune hypophysitis in SJL mice and how to assess its severity by histopathology.
09:03
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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Cited by 31 •
2012
Infection of mice with an Adenovirus expressing the major human autoantigen cytochrome P450 2D6 (hCYP2D6) recognized by sera of patients suffering from type 2 autoimmune hepatitis results in a persistent form of autoimmune-mediated liver disease characterized by extensive hepatitis, fibrosis and generation of a CYP2D6-specific immune response.
04:12
Acute Biliary Pancreatitis Model: A Method to Generate Acute Biliary Pancreatitis Mouse Model via Pancreatic Duct Infusion
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2025
This video describes the procedure for the generation of a mouse model with acute biliary pancreatitis via pancreatic infusion of sodium taurocholate. This model helps study pathophysiological changes induced by sodium taurocholate in the pancreas.
11:54
Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
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Cited by 20 •
2009
Achieving high quality and appropriate quantity of human islets is one of the prominent prerequisites for successful islet transplantation. In this video, we describe step by step the procedures for human pancreatic islet isolation (part I: digestion and collection of pancreatic tissue) using a modified automated method.
05:11
Treatment of Middle-segment Pancreatic Benign Tumor Using Laparoscopic Central Pancreatectomy with End-to-end Pancreatic Duct Reconstruction
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2026
This article presents laparoscopic central pancreatectomy with pancreatic duct end-to-end anastomosis as an important surgical approach for middle-segment pancreatic benign and low-grade malignant tumors.
FAQs
Immune-mediated injury can sustain lymphoplasmacytic inflammation, which promotes pancreatic swelling and fibrosis. As fibrotic tissue develops, the pancreatic duct may become narrowed, disrupting normal pancreatic flow. Ongoing structural damage can impair both digestive and endocrine functions, explaining why patients may develop abdominal discomfort, obstructive jaundice, or diabetes as the disease progresses.
An increased number of IgG4-positive plasma cells can support recognition of a particular inflammatory pattern within the pancreas. Their presence also raises the possibility that the pancreatic process is part of IgG4-related disease, in which inflammation may affect other organs. This finding therefore contributes to broader clinical assessment rather than describing an isolated pancreatic abnormality alone.
Autoimmune Pancreatitis may produce either diffuse or focal pancreatic enlargement and can narrow the pancreatic duct. These structural changes may resemble a pancreatic mass or another obstructing process, creating an important diagnostic challenge. Distinguishing the conditions matters because the diagnosis determines whether clinicians pursue corticosteroid treatment and monitoring for relapse rather than manage the presentation as presumed malignancy.
Evaluation is particularly relevant when pancreatic enlargement or duct narrowing occurs alongside obstructive jaundice, abdominal discomfort, or newly recognized impaired endocrine function such as diabetes. The clinical picture should also raise attention to possible inflammation in other organs. Considering these findings together helps clinicians avoid focusing only on the pancreatic abnormality and supports a more accurate diagnosis.
Once the diagnosis is established, corticosteroid treatment is an important management approach. Care does not end when symptoms or pancreatic abnormalities improve, because the disease can relapse. Ongoing clinical monitoring therefore helps identify recurrent inflammation and reassess pancreatic function, while also allowing clinicians to respond to changes in associated organ involvement when IgG4-related disease is suspected.
Autoimmune Pancreatitis may occur as part of IgG4-related disease, so clinicians need to consider whether inflammation is affecting organs outside the pancreas. This broader assessment can influence diagnosis and follow-up, especially when pancreatic findings coexist with obstructive jaundice, abdominal symptoms, or functional impairment. Monitoring associated organs also helps provide a more complete picture of disease activity and recurrence.