Flaccid Hemiplegia

Flaccid hemiplegia is paralysis affecting one side of the body accompanied by markedly reduced muscle tone, usually reflecting disruption of motor pathways in the brain or spinal cord. It commonly appears after an acute upper motor neuron injury, such as a stroke, when interrupted descending signals impair voluntary movement and temporarily reduce reflex activity; spasticity may develop during later recovery. Clinical assessment examines strength, tone, reflexes, sensation, coordination, and associated neurological signs to identify the lesion and guide urgent care. Recognizing this pattern supports differential diagnosis, rehabilitation planning, prevention of contractures and falls, and monitoring of changing motor function over time.

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Research

JoVE Journal - Biology

Isolation and Culture of Adult Mouse Cardiomyocytes for Cell Signaling and in vitro Cardiac Hypertrophy

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Cited by 74 •

2014

We describe a reliable method for isolation of adult mouse cardiomyocytes. This protocol yields a consistent result for the culture of functional adult cardiomyocytes from a variety of genetically modified mice.

Education

JoVE Science Education - Basic Biology

Diagnostic Necropsy and Tissue Harvest

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2016

Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN Many animal experiments rely on final data collection time points that are gathered from the harvesting and testing of organs and tissues. The use of appropriate methods for the collection of organs and tissues can impact the quality of the samples and the analysis of the data that is gleaned for the testing of the tissues. The method of euthanasia of the animal can also impact the quality of...

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