Retinal Thickness
Retinal Thickness - Related Videos
08:17
Organotypic Culture of Full-thickness Adult Porcine Retina
0 Views •
Cited by 19 •
2011
Here we describe a cost-effective technique for organotypic culture of adult porcine retina for seven days. Briefly, a sterile filter paper was used to lift the neural retina off from the RPE and place photoreceptor side up on an insert raised by a custom-made stand.
09:17
Using Retinal Imaging to Study Dementia
0 Views •
Cited by 19 •
2017
The retina shares prominent similarities with the brain and thus represents a unique window to study vasculature and neuronal structure in the brain non-invasively. This protocol describes a method to study dementia using retinal imaging techniques. This method can potentially aid in diagnosis and risk assessment of dementia.
07:59
Murine Full-thickness Skin Transplantation
0 Views •
Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
10:00
Techniques for Processing Eyes Implanted with a Retinal Prosthesis for Localized Histopathological Analysis: Part 2 Epiretinal Implants with Retinal Tacks
0 Views •
Cited by 23 •
2015
Here we describe histological techniques for visualising ocular tissue directly adjacent to a metal epiretinal tack and retinal prosthesis.
03:13
Lymphedema Ultrasonography: A Technique to Measure the Change in Thickness of an Affected Tissue
0 Views •
2023
This video utilizes ultrasonography for diagnosis and follow-up tests to determine treatment efficacy of Progressive Resistance Exercise (PRE) in breast cancer-related lymphedema (BCRL). Ultrasonography can be applied effectively to ensure diagnosis and treatment of lymphedema.
FAQs
Optical coherence tomography (OCT) uses reflected light to create high-resolution cross-sectional images, preserving the visible arrangement of retinal layers for measurement. Researchers can assess the full retinal thickness or isolate layers such as the nerve fiber and ganglion cell layers. This layer-resolved approach connects a numerical measurement with a specific part of the neural tissue.
Examining individual layers can reveal changes that a total-thickness value may not identify clearly. Measurements of the nerve fiber and ganglion cell layers, for example, help localize structural differences within the retina. That distinction matters because retinal thickness studies may address neurodegeneration, development, injury, disease, or remodeling in particular tissue regions rather than only overall size.
Changes in retinal thickness may reflect localized tissue loss, swelling, or remodeling. These outcomes represent different forms of structural alteration, so thickness is useful not merely as a single size measurement but as an indicator of retinal organization and health. In neuroscience studies, identifying where such changes occur can support analysis of neural tissue responses.
Researchers can quantify total retinal thickness from an OCT cross-sectional image or measure selected layers separately. The choice depends on whether the study needs an overall structural value or a layer-specific readout, such as one involving the nerve fiber or ganglion cell layer. Both approaches use the same reflected-light imaging basis.
It supports investigations of neurodegeneration, development, injury, and disease by providing structural measurements from neural tissue at the back of the eye. Because OCT supplies high-resolution cross-sectional information, researchers can examine localized loss, swelling, or remodeling within these research contexts rather than relying only on broad descriptions of retinal health.
The retina provides neural tissue that can be assessed structurally without invasive sampling in the measurement approach described. Its thickness and layer-specific changes may therefore offer clues about processes occurring within the retina and may reflect broader changes in the nervous system. This connection gives neuroscience studies a structural measure with relevance beyond the eye alone.