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Cancer Research

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JoVE Journal Cancer Research
En preklinisk musmodell av osteosarkom att definiera den extracellulära vesikler-medierad kommunikationen mellan tumör och mesenkymala stamceller
Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System
Journal (Cancer Research)
Analyzing the Communication Between Monocytes and Primary Breast Cancer Cells in an Extracellular Matrix Extract (ECME)-based Three-dimensional System
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Journal (Cancer Research)
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
 
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En preklinisk musmodell av osteosarkom att definiera den extracellulära vesikler-medierad kommunikationen mellan tumör och mesenkymala stamceller

Article DOI: 10.3791/56932-v • 11:15 min • May 6th, 2018
May 6th, 2018 •
*1, *2, 2
1Neuro-oncology Research Group, VU Medical Center, 2Exosomes Research Group, Department of Pathology, VU Medical Center
* These authors contributed equally

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Direktinsprutning av cancer-derived extracellulära blåsor (EVs) leder till omprogrammering av benmärg stödja tumör progression; Det är dock oklart vilka celler medla denna effekt. Häri, beskriver vi ett stegvisa protokoll för att undersöka EV-medierad tumör-mesenkymala stamceller (MSC) interaktioner i vivo, avslöjar en avgörande roll för EV-utbildade MSCs i metastaser.

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Cancerforskning fråga 135 ortotop cancer musmodell mesenkymala stamceller extracellulär blåsor tumör mikromiljö metastaser osteosarkom
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