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Cancer Research

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JoVE Journal Cancer Research
Generering av høy gjennomstrømming tredimensjonale svulst Spheroids for narkotikarelaterte Screening
Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
Journal (Cancer Research)
Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Journal (Cancer Research)
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
 
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Generering av høy gjennomstrømming tredimensjonale svulst Spheroids for narkotikarelaterte Screening

Article DOI: 10.3791/57476-v • 05:54 min • September 5th, 2018
September 5th, 2018 •
1, 1, 2, 2, 2, 2, 2, 1
1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research

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Over en rekke sykdom indikasjoner blir flere fysiologisk relevante modeller utviklet og implementert i stoffet funnet programmer. Den nye modell systemet beskrevet her demonstrerer hvordan tredimensjonale svulst spheroids kan kultivert og vist i en høy gjennomstrømming 1536-vel plate-basert system til å søke etter nye onkologi stoffer.

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Kreftforskning problemet 139 Tumor spheroids tredimensjonale (3D) flere godt plater narkotika sortering høy gjennomstrømning og definerte medium
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