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Modellering Osteosarcoma bruker Li-Fraumeni syndrom pasient-avledede Induced Pluripotent stamceller

Article DOI: 10.3791/57664-v • 08:52 min • June 13th, 2018
June 13th, 2018 •
1,2, 1, 1,3, 1, 4, 1, 1,2,5,6
1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 2Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, 3Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, 4Women's Health Institute, Cleveland Clinic Foundation, 5Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, 6Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston

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Her presenterer vi en protokoll for generering av indusert pluripotent stamceller (iPSCs) fra Li-Fraumeni syndrom (AKU) pasienten avledede fibroblaster, differensiering av iPSCs via stamceller (MSCs) osteoblasts og modellering i vivo tumorigenesis bruker AKU pasient-avledede osteoblasts.

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Kreftforskning problemet 136 iPSCs Li-Fraumeni syndrom omprogrammering differensiering mesenchymal stamceller osteoblasts osteosarcoma xenograft
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