David J. Marcinek

Publications

• Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes
  Diabetes. Mar, 2024  |   Pubmed ID: 38551899
• Childhood Adverse Life Events and Skeletal Muscle Mitochondrial Function
  Science Advances. Mar, 2024  |   Pubmed ID: 38446898
• Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA)
  Aging Cell. Feb, 2024  |   Pubmed ID: 38332629
• Energetics and Clinical Factors for the Time Required to Walk 400 m: The Study of Muscle, Mobility and Aging (SOMMA)
  Journal of the American Geriatrics Society. Apr, 2024  |   Pubmed ID: 38243364
• Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Apr, 2024  |   Pubmed ID: 38150179
• Lower Muscle Mitochondrial Energetics is Associated with Greater Phenotypic Frailty in Older Women and Men: the Study of Muscle, Mobility and Aging
  GeroScience. Apr, 2024  |   Pubmed ID: 37987886
• Mitochondrial Targeted Interventions for Aging
  Cold Spring Harbor Perspectives in Medicine. Mar, 2024  |   Pubmed ID: 37788882
• Older-aged C57BL/6 Mice Fed a Diet High in Saturated Fat and Sucrose for Ten Months Show Decreased Resilience to Aging
  Aging Pathobiology and Therapeutics. 2023  |   Pubmed ID: 38706773
• Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA)
  MedRxiv : the Preprint Server for Health Sciences. Nov, 2023  |   Pubmed ID: 37986748
• Age-related Changes of Skeletal Muscle Metabolic Response to Contraction Are Also Sex-dependent
  The Journal of Physiology. Sep, 2023  |   Pubmed ID: 37742081
• The Mitochondrially Targeted Peptide Elamipretide (SS-31) Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake Through the Adenine Nucleotide Translocator (ANT)
  GeroScience. Dec, 2023  |   Pubmed ID: 37462785
• A Novel Mitochondrial Complex I ROS Inhibitor Partially Improves Muscle Regeneration in Adult but Not Old Mice
  Redox Biology. Aug, 2023  |   Pubmed ID: 37295159
• Randomized Crossover Clinical Trial of Coenzyme Q10 and Nicotinamide Riboside in Chronic Kidney Disease
  JCI Insight. Jun, 2023  |   Pubmed ID: 37159264
• Skeletal Muscle Mitochondrial Interactome Remodeling is Linked to Functional Decline in Aged Female Mice
  Nature Aging. Mar, 2023  |   Pubmed ID: 37118428
• Age and Sex As Determinants of Acute Domoic Acid Toxicity in a Mouse Model
  Toxins. Apr, 2023  |   Pubmed ID: 37104198
• Intermittent Treatment with Elamipretide Preserves Exercise Tolerance in Aged Female Mice
  GeroScience. Aug, 2023  |   Pubmed ID: 36840897
• ATP and NAD Deficiency in Parkinson's Disease
  Nutrients. Feb, 2023  |   Pubmed ID: 36839301
• From Mitochondria to Cells to Humans: Targeting Bioenergetics in Aging and Disease
  The International Journal of Biochemistry & Cell Biology. Apr, 2023  |   Pubmed ID: 36806357
• The Multi-tissue Landscape of Somatic MtDNA Mutations Indicates Tissue-specific Accumulation and Removal in Aging
  ELife. Feb, 2023  |   Pubmed ID: 36799304
• Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake Through the Adenine Nucleotide Translocator (ANT)
  BioRxiv : the Preprint Server for Biology. Feb, 2023  |   Pubmed ID: 36778398
• The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Oct, 2023  |   Pubmed ID: 36754371
• DATP Elevation Induces Myocardial Metabolic Remodeling to Support Improved Cardiac Function
  Journal of Molecular and Cellular Cardiology. Feb, 2023  |   Pubmed ID: 36470336
• Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Aug, 2023  |   Pubmed ID: 36462195
• Aging Increases Susceptibility to Develop Cardiac Hypertrophy Following High Sugar Consumption
  Nutrients. Nov, 2022  |   Pubmed ID: 36364920
• Elamipretide Effects on the Skeletal Muscle Phosphoproteome in Aged Female Mice
  GeroScience. Dec, 2022  |   Pubmed ID: 36322234
• Long-term Treatment with Elamipretide Enhances Healthy Aging Phenotypes in Mice
  Aging Pathobiology and Therapeutics. 2022  |   Pubmed ID: 36250163
• Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial
  JAMA Network Open. Jan, 2022  |   Pubmed ID: 35050355
• An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice
  Investigative Ophthalmology & Visual Science. Nov, 2021  |   Pubmed ID: 34797906
• Ice Seals As Sentinels for Algal Toxin Presence in the Pacific Arctic and Subarctic Marine Ecosystems
  Marine Mammal Science. Oct, 2021  |   Pubmed ID: 34690417
• A Replication-linked Mutational Gradient Drives Somatic Mutation Accumulation and Influences Germline Polymorphisms and Genome Composition in Mitochondrial DNA
  Nucleic Acids Research. Nov, 2021  |   Pubmed ID: 34614167
• Elamipretide (SS-31) Treatment Attenuates Age-associated Post-translational Modifications of Heart Proteins
  GeroScience. Oct, 2021  |   Pubmed ID: 34480713
• In Vivo Mitochondrial ATP Production is Improved in Older Adult Skeletal Muscle After a Single Dose of Elamipretide in a Randomized Trial
  PloS One. 2021  |   Pubmed ID: 34264994
• Astaxanthin Supplementation Enhances Metabolic Adaptation with Aerobic Training in the Elderly
  Physiological Reports. Jun, 2021  |   Pubmed ID: 34110707
• Are Fat and Sugar Just As Detrimental in Old Age?
  GeroScience. Aug, 2021  |   Pubmed ID: 34101101
• High Intensity Muscle Stimulation Activates a Systemic Nrf2-mediated Redox Stress Response
  Free Radical Biology & Medicine. Aug, 2021  |   Pubmed ID: 34089788
• Reduction of Elevated Proton Leak Rejuvenates Mitochondria in the Aged Cardiomyocyte
  ELife. Dec, 2020  |   Pubmed ID: 33319746
• Increased Tumour Burden Alters Skeletal Muscle Properties in the KPC Mouse Model of Pancreatic Cancer
  JCSM Rapid Communications. 2020  |   Pubmed ID: 33073264
• SS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts
  Aging Cell. Oct, 2020  |   Pubmed ID: 32779818
• Mitochondrial Protein Interaction Landscape of SS-31
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2020  |   Pubmed ID: 32554501
• Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor
  Toxins. May, 2019  |   Pubmed ID: 31126088
• Improving Mitochondrial Function with SS-31 Reverses Age-related Redox Stress and Improves Exercise Tolerance in Aged Mice
  Free Radical Biology & Medicine. 04, 2019  |   Pubmed ID: 30597195
• Repeated Low Level Domoic Acid Exposure Increases CA1 VGluT1 Levels, but Not Bouton Density, VGluT2 or VGAT Levels in the Hippocampus of Adult Mice
  Harmful Algae. Nov, 2018  |   Pubmed ID: 30420019
• Domoic Acid in California Sea Lion Fetal Fluids Indicates Continuous Exposure to a Neuroteratogen Poses Risks to Mammals
  Harmful Algae. Nov, 2018  |   Pubmed ID: 30420016
• Building Strength, Endurance, and Mobility Using an Astaxanthin Formulation with Functional Training in Elderly
  Journal of Cachexia, Sarcopenia and Muscle. Oct, 2018  |   Pubmed ID: 30259703
• Fatiguing Contractions Increase Protein S-glutathionylation Occupancy in Mouse Skeletal Muscle
  Redox Biology. 07, 2018  |   Pubmed ID: 29857311
• Cyclophosphamide Leads to Persistent Deficits in Physical Performance and in Vivo Mitochondria Function in a Mouse Model of Chemotherapy Late Effects
  PloS One. 2017  |   Pubmed ID: 28700655
• Effect of Contaminants of Emerging Concern on Liver Mitochondrial Function in Chinook Salmon
  Aquatic Toxicology (Amsterdam, Netherlands). Sep, 2017  |   Pubmed ID: 28668760
• Chronic Low-level Exposure to the Common Seafood Toxin Domoic Acid Causes Cognitive Deficits in Mice
  Harmful Algae. Apr, 2017  |   Pubmed ID: 28427569
• Mitochondrial Protein Interactome Elucidated by Chemical Cross-linking Mass Spectrometry
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2017  |   Pubmed ID: 28130547
• Acute and Chronic Dietary Exposure to Domoic Acid in Recreational Harvesters: A Survey of Shellfish Consumption Behavior
  Environment International. Apr, 2017  |   Pubmed ID: 28109640
• The Mitochondrial-targeted Peptide, SS-31, Improves Glomerular Architecture in Mice of Advanced Age
  Kidney International. May, 2017  |   Pubmed ID: 28063595
• Skeletal Muscle Bioenergetics in Aging and Heart Failure
  Heart Failure Reviews. Mar, 2017  |   Pubmed ID: 27815651
• Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through CGMP-Dependent Mechanisms
  Antioxidants & Redox Signaling. Jun, 2017  |   Pubmed ID: 27393340
• NAD+ Repletion Improves Muscle Function in Muscular Dystrophy and Counters Global PARylation
  Science Translational Medicine. Oct, 2016  |   Pubmed ID: 27798264
• Evaluation of in Vivo Mitochondrial Bioenergetics in Skeletal Muscle Using NMR and Optical Methods
  Biochimica Et Biophysica Acta. Apr, 2016  |   Pubmed ID: 26708941
• Age Modifies Respiratory Complex I and Protein Homeostasis in a Muscle Type-specific Manner
  Aging Cell. Feb, 2016  |   Pubmed ID: 26498839
• Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury
  Toxicological Sciences : an Official Journal of the Society of Toxicology. Jan, 2016  |   Pubmed ID: 26494550
• The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function
  Frontiers in Physiology. 2015  |   Pubmed ID: 26635632
• Effect of Omega-3 Fatty Acid Oxidation Products on the Cellular and Mitochondrial Toxicity of BDE 47
  Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2015  |   Pubmed ID: 25659769
• In Vivo Metabolic Spectroscopy Identifies Deficits in Mitochondrial Quality and Capacity in Aging Skeletal Muscle
  Clinical Pharmacology and Therapeutics. Dec, 2014  |   Pubmed ID: 25207702
• Chronic Low-level Domoic Acid Exposure Alters Gene Transcription and Impairs Mitochondrial Function in the CNS
  Aquatic Toxicology (Amsterdam, Netherlands). Oct, 2014  |   Pubmed ID: 25033243
• Mitochondrial Oxidative Stress in Aging and Healthspan
  Longevity & Healthspan. 2014  |   Pubmed ID: 24860647
• Targeting Redox Biology to Reverse Mitochondrial Dysfunction
  Aging. Aug, 2013  |   Pubmed ID: 23945201
• Mitochondrial-targeted Peptide Rapidly Improves Mitochondrial Energetics and Skeletal Muscle Performance in Aged Mice
  Aging Cell. Oct, 2013  |   Pubmed ID: 23692570
• Higher Mitochondrial Respiration and Uncoupling with Reduced Electron Transport Chain Content in Vivo in Muscle of Sedentary Versus Active Subjects
  The Journal of Clinical Endocrinology and Metabolism. Jan, 2013  |   Pubmed ID: 23150693
• Defects in Mitochondrial Localization and ATP Synthesis in the Mdx Mouse Model of Duchenne Muscular Dystrophy Are Not Alleviated by PDE5 Inhibition
  Human Molecular Genetics. Jan, 2013  |   Pubmed ID: 23049075
• Impaired Adaptability of in Vivo Mitochondrial Energetics to Acute Oxidative Insult in Aged Skeletal Muscle
  Mechanisms of Ageing and Development. 2012  |   Pubmed ID: 22935551
• A Novel Antibody-based Biomarker for Chronic Algal Toxin Exposure and Sub-acute Neurotoxicity
  PloS One. 2012  |   Pubmed ID: 22567140
• Reduced Coupling of Oxidative Phosphorylation in Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice
  PloS One. 2011  |   Pubmed ID: 22132085
• Mitochondrial Oxidative Stress Mediates Angiotensin II-induced Cardiac Hypertrophy and Galphaq Overexpression-induced Heart Failure
  Circulation Research. Apr, 2011  |   Pubmed ID: 21311045
• Age-dependent Cardiomyopathy in Mitochondrial Mutator Mice is Attenuated by Overexpression of Catalase Targeted to Mitochondria
  Aging Cell. Aug, 2010  |   Pubmed ID: 20456298
• Lactic Acidosis in Vivo: Testing the Link Between Lactate Generation and H+ Accumulation in Ischemic Mouse Muscle
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2010  |   Pubmed ID: 20133437
• Mitochondrial Function in Vivo: Spectroscopy Provides Window on Cellular Energetics
  Methods (San Diego, Calif.). Dec, 2008  |   Pubmed ID: 18930151
• Mice with Mitochondrial Complex I Deficiency Develop a Fatal Encephalomyopathy
  Cell Metabolism. Apr, 2008  |   Pubmed ID: 18396137
• Mitochondrial Dysfunction and Age
  Current Opinion in Clinical Nutrition and Metabolic Care. Nov, 2007  |   Pubmed ID: 18089948
• Wavelength Shift Analysis: a Simple Method to Determine the Contribution of Hemoglobin and Myoglobin to in Vivo Optical Spectra
  Applied Spectroscopy. Jun, 2007  |   Pubmed ID: 17650380
• Mitochondrial Dysfunction: Impact on Exercise Performance and Cellular Aging
  Exercise and Sport Sciences Reviews. Apr, 2007  |   Pubmed ID: 17417049
• Mild Mitochondrial Uncoupling Impacts Cellular Aging in Human Muscles in Vivo
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007  |   Pubmed ID: 17215370
• Mitochondrial Function, Fibre Types and Ageing: New Insights from Human Muscle in Vivo
  Experimental Physiology. Mar, 2007  |   Pubmed ID: 17170059
• Reduced Mitochondrial Coupling in Vivo Alters Cellular Energetics in Aged Mouse Skeletal Muscle
  The Journal of Physiology. Dec, 2005  |   Pubmed ID: 16254011
• Mitochondrial Coupling in Vivo in Mouse Skeletal Muscle
  American Journal of Physiology. Cell Physiology. Feb, 2004  |   Pubmed ID: 14522819
• Oxygen Regulation and Limitation to Cellular Respiration in Mouse Skeletal Muscle in Vivo
  American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2003  |   Pubmed ID: 12775561
• Basal Glycogenolysis in Mouse Skeletal Muscle: in Vitro Model Predicts in Vivo Fluxes
  Molecular Biology Reports. 2002  |   Pubmed ID: 12241044