Cardiovascular Disease Therapy
Cardiovascular Disease Therapy - Related Videos
01:27
Psychoneuroimmunology: Cardiovascular Disease
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2025
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases. A key area of focus in PNI is the relationship between stress and coronary...
23:53
Ole Isacson: Development of New Therapies for Parkinson's Disease
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Cited by 1 •
2007
Ole Isacson gives a concise overview of Parkinsons's disease, its causes, therapeutic strategies, and advances in Parkinson's research.
09:09
In Silico Clinical Trials for Cardiovascular Disease
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Cited by 3 •
2022
This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic outcomes.
15:48
ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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Cited by 1 •
2007
Jeffrey D. Rothstein speaks about the pathology and mechanisms underlying amyotrophic lateral sclerosis or ALS, advances in ALS research, and current strategies towards the development of therapies.
07:25
Isolation and Excision of Murine Aorta; A Versatile Technique in the Study of Cardiovascular Disease
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Cited by 16 •
2014
Pathology of the aorta can lead to severe morbidity and mortality, therefore research of disease progression and potential therapies is warranted. Here, we present a protocol to isolate and excise the murine aorta to aid researchers in their investigation of cardiovascular disease.
FAQs
Bioengineered approaches can direct treatment toward a specific cardiovascular need rather than relying on a single general strategy. Targeted drug delivery systems focus therapeutic agents, while implantable devices and tissue-engineered grafts address structural or flow-related problems. This precision may support more controlled treatment, reduce complications, and help clinicians develop care that better reflects individual disease patterns.
Biomaterials provide an important foundation for devices, delivery systems, and engineered grafts used in cardiovascular care. Their performance must be considered alongside safety and how well the treatment integrates with the body over time. In bioengineering research, biomaterial-based designs therefore help connect the intended therapeutic function with durability and biological compatibility.
Treatments may need to modify an active disease driver, such as abnormal blood pressure, clot formation, or impaired blood flow, while also addressing damage to cardiovascular structures. Focusing on only one aspect may leave the underlying problem or its physical consequences unresolved. Combining these goals can improve circulation, reduce complications, and support restoration when replacement is needed.
Evaluation considers more than whether an intervention produces an immediate therapeutic effect. Researchers examine treatment safety, functional performance, and long-term integration with the body. Bioengineered research models provide structured ways to assess these outcomes before or during development, helping identify whether a device, delivery system, or graft can meet its intended cardiovascular purpose.
Development begins by identifying whether the primary need concerns a disease driver, impaired blood flow, or damaged cardiovascular structure. Researchers then select an appropriate strategy, such as targeted delivery, an implantable device, or a tissue-engineered graft. The candidate is subsequently assessed for safety, performance, and integration, with results guiding refinement and potential personalized use.
The choice depends on the treatment problem being addressed. Targeted delivery systems are suited to directing therapy, implantable devices support intervention through an engineered structure, and tissue-engineered grafts focus on replacing or restoring damaged cardiovascular components. These options represent different bioengineering routes for improving circulation or repairing the cardiovascular system.
Personalized care can use the range of available interventions to match treatment design with a patient’s specific cardiovascular condition. Disease drivers, impaired flow, and structural damage may require different combinations of medical, surgical, or bioengineered strategies. Biomaterials, delivery systems, devices, and grafts expand the options available for tailoring therapy while maintaining attention to safety and integration.