Coaxial Flow Focusing

Coaxial flow focusing is a microfluidic technique that uses concentric fluid streams to precisely control the size and transport of a central flow, making it valuable in bioengineering. An inner fluid passes through a narrow channel while one or more surrounding sheath fluids compress it through hydrodynamic focusing; adjusting flow rates, pressures, and fluid properties controls the focused stream and can promote droplet formation. This approach supports the generation of uniform droplets, particles, fibers, and microcapsules for cell encapsulation, drug delivery, tissue engineering, and biochemical assays. Its reproducibility and fine spatial control enable scalable fabrication of engineered biological materials and model systems.

Coaxial Flow Focusing - Related Videos

Research

JoVE Journal - Bioengineering

Double Emulsion Generation Using a Polydimethylsiloxane (PDMS) Co-axial Flow Focus Device

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Cited by 8 •

2015

Microfluidic double emulsions generation typically involves devices with patterned wettability or custom-fabricated glass components. Here we describe the fabrication and testing of an all polydimethylsiloxane (PDMS) double emulsion generator that does not require surface treatment or complicated fabrication processes, and is capable of producing double emulsions down to 14 µm.

Education

JoVE Core - Physics

Energy Stored In A Coaxial Cable

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2023

A coaxial cable consists of a central copper conductor used for transmitting signals, followed by an insulator shield, a metallic braided mesh that prevents signal interference, and a plastic layer that encases the entire assembly. In the simplest form, a coaxial cable can be represented by two long hollow concentric cylinders in which the current flows in opposite directions. The magnetic field inside and outside the coaxial cable is determined by using Ampère's law. The magnetic field inside...

Research

JoVE Journal - Engineering
Free Sample

Preparation and Use of Photocatalytically Active Segmented Ag|ZnO and Coaxial TiO2-Ag Nanowires Made by Templated Electrodeposition

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Cited by 1 •

2014

Procedures are outlined to prepare segmented and coaxial nanowires via templated electrodeposition in nanopores. As examples, segmented nanowires consisting of Ag and ZnO segments, and coaxial nanowires consisting of a TiO2 shell and a Ag core were made. The nanowires were used in photocatalytic hydrogen formation experiments.

Inducing a Spinal Cord Contusion in a Mouse Model Using a Spinal Cord Injury Coaxial Platform

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2025

Source: Elzat, E. Y. Y., et al., Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique. J. Vis. Exp. (2022).This video demonstrates the method for inducing a contusion injury at the T9 level spinal cord in a mouse model, using a spinal cord injury coaxial platform. A weight is dropped on the T9 level spinal cord that creates a contusion that immediately causes tissue discoloration and swelling.

Real-time Monitoring of High Intensity Focused Ultrasound (HIFU) Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound (HMIFU)

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Cited by 13 •

2015

This article describes real-time monitoring of HIFU ablation in canine liver with high frame rate ultrasound imaging using diverging and plane wave imaging. Harmonic Motion Imaging for Focused Ultrasound is used to image the decrease of acoustic radiation force induced displacement in the ablated region.

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