Mesh-shaped Constructs
Mesh-shaped Constructs - Related Videos
05:05
Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
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Cited by 2 •
2020
The present protocol generates mesh-shaped engineered cardiac tissues containing cardiovascular cells derived from human induced pluripotent stem cells to allow the investigation of cell implantation therapy for heart diseases.
10:32
Transvaginal Mesh Insertion in the Ovine Model
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Cited by 11 •
2017
This protocol describes mesh implantation in the ovine rectovaginal septum using a single vaginal incision technique, with and without the trocar-guided insertion of anchoring arms.
01:20
Mesh Analysis
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2024
Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved. A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
13:43
Fabrication of Myogenic Engineered Tissue Constructs
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Cited by 11 •
2009
Here, we demonstrate fabrication of collagen-based, tissue constructs containing skeletal myoblasts. These 3-D engineered constructs may be used to replace or repair tissues in vivo. For our purposes, we have designed these as an atrioventricular electrical conduit for the repair of complete heart block[1].
03:37
Molecular Shape and Polarity
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2020
Dipole Moment of a Molecule Polar covalent bonds connect two atoms with differing electronegativities, leaving one atom with a partial positive charge (δ+) and the other atom with a partial negative charge (δ–), as the electrons are pulled toward the more electronegative atom. This separation of charge gives rise to a bond dipole moment. The magnitude of a bond dipole moment is represented by the Greek letter mu (µ) and is given by the formula shown here, where Q is the magnitude of the...
FAQs
Mesh size strongly influences the balance between cell access and internal transport. Smaller openings can alter how cells attach and grow, while larger openings may change the movement of nutrients, oxygen, and waste through the construct. In bioengineering, selecting mesh dimensions helps tailor the scaffold to the intended cellular and transport environment.
Material properties determine how the framework supports biological and synthetic components, while degradation rate affects how long that support remains available. These factors must be considered together because a construct may need to maintain organization while cells attach and grow. Matching material behavior with the intended application helps preserve useful structure during bioengineering experiments.
Interconnected fibers and strands create a continuous framework that can guide the placement and growth of cells throughout three dimensions. This organization combines structural support with an open pathway for nutrient, oxygen, and waste movement. Such coordinated architecture is important when researchers aim to reproduce aspects of the physical environment found in living tissues.
A design process begins by relating the intended use to mesh size, material properties, and degradation rate. Researchers then consider whether the construct must prioritize cell attachment, internal transport, structural organization, or a combination of these features. This approach supports more deliberate choices for tissue regeneration, drug delivery, wound repair, or biomimetic model development.
These constructs are useful when a bioengineered material must provide a supportive framework while allowing cells and transported substances to occupy the structure. Their flexibility and interconnected architecture can support research on tissue regeneration and wound repair. Researchers can adjust mesh dimensions and material behavior to study how scaffold design affects cellular organization and tissue-related outcomes.
For drug delivery, the open framework provides a three-dimensional structure in which material organization and transport can be examined together. In biomimetic models, the same architecture helps researchers reproduce selected physical features of living tissues. These applications extend beyond simple structural support by using mesh design to investigate how materials interact with biological environments.