Intrahepatic Jaundice
Intrahepatic Jaundice - Related Videos
01:25
Jaundice
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2026
Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
03:45
Right Hemihepatectomy by Suprahilar Intrahepatic Transection of the Right Hemipedicle using a Vascular Stapler
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Cited by 1 •
2010
This video describes a right hemihepatectomy with intrahepatic transection of the right hemipedicle leaving the hepatoduodenal ligament completely untouched.
10:35
Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice
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Cited by 15 •
2013
Human tumor xenografts in immunodeficient mice are valuable tools to study cancer biology. Specific protocols to generate subcutaneous and intrahepatic xenografts from human hepatocellular carcinoma cells or tumor fragments are described. Liver regeneration induced by partial hepatectomy in recipient mice is presented as a strategy to facilitate intrahepatic engraftment.
07:55
The Influence of Liver Resection on Intrahepatic Tumor Growth
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Cited by 6 •
2016
A high incidence of tumor recurrence after resection of liver metastases remains an unsolved problem. The illustrated mouse model may be useful to investigate the reasons for such recurrences. It combines a liver resection model with intrahepatic tumor cell injection for the first time.
06:41
Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
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Cited by 1 •
2021
Here we present refined surgical procedures on successfully performing intraportal islet transplantation, a clinically relevant but technically challenging surgical procedure, in mice.
FAQs
The central disruptions involve bilirubin uptake, conjugation, and excretion by hepatocytes. Injury to these cells can impair one or several steps, allowing bilirubin to accumulate and produce jaundice. This mechanism explains why intrahepatic disease may reflect direct hepatocellular injury, impaired processing within liver cells, or both, rather than a single uniform biochemical defect.
Inflammation and cholestasis can interfere with bile movement through the liver even when the initiating problem is intrahepatic. Reduced bile flow limits bilirubin excretion and contributes to its accumulation. Recognizing this mechanism is important because impaired flow within the liver differs biologically from obstruction caused by an extrahepatic process, although both can disturb bilirubin handling.
Distinguishing these patterns requires comparing bilirubin fractions with aminotransferases and alkaline phosphatase, then considering the clinical history and imaging findings. The combined pattern helps separate impaired hepatic processing from jaundice related to hemolysis or bile-flow obstruction outside the liver. No single measurement is presented as sufficient for classification in the available information.
These conditions can injure the liver through different clinical contexts while converging on disrupted hepatocyte function or intrahepatic bile flow. Viral hepatitis, drug-induced liver injury, and alcohol-related disease are therefore important causes to consider when evaluating this jaundice pattern. Identifying the relevant context supports interpretation of laboratory and imaging findings and helps guide treatment.
Evaluation begins by assessing bilirubin fractions together with aminotransferases and alkaline phosphatase. Clinicians then incorporate the patient’s clinical history and use imaging to examine the hepatobiliary context. Interpreting these findings together helps distinguish intrahepatic disease from hemolytic or extrahepatic causes, providing a basis for identifying the likely process and guiding treatment.
Bilirubin fractions characterize the disturbance in bilirubin handling, while aminotransferases and alkaline phosphatase add evidence about liver-cell injury and disrupted bile flow. Clinical history can point toward contexts such as viral hepatitis, drug exposure, or alcohol-related disease, and imaging contributes structural information. Their combined interpretation improves classification of the jaundice pattern and supports management decisions.