Proximal Tibia
Proximal Tibia - Related Videos
04:00
Isolation and Culture of Bone Marrow Stromal Cells from a Mouse Tibia
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2025
In this video, we demonstrate the isolation and culture of bone marrow stromal cells from the long bones of mice. The isolated adherent BMSCs can be used for further analysis.
01:10
Bones of the Lower Limb: Tibia and Fibula
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2025
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
07:06
Isolation of Primary Human Proximal Tubule Epithelial Cells and Their Use in Creating a Microphysiological Model of the Renal Proximal Tubule
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Cited by 3 •
2025
We present an optimized protocol for processing whole human kidneys to isolate and culture primary renal proximal tubule epithelial cells and the application of these cells in a three-dimensional, microfluidic, microphysiological platform to recapitulate the renal proximal tubule.
03:32
Amplified Luminescent Proximity Homogeneous Assay: A Bead-Based Proximity Assay to Screen Small Molecules Inhibiting Protein-Protein Interactions
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2025
In this video, we demonstrate the amplified luminescent proximity homogeneous assay—a bead-based proximity assay. It utilizes homogeneously-sized acceptor and donor beads, immobilized with two proteins that tend to interact to screen potential small molecules inhibiting protein interactions.
02:08
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
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Cited by 2 •
2024
The placement of implants in a rat model is an essential experimental procedure for clinical research. This study presents a comprehensive surgical protocol for implanting titanium implants into the tibia of rat models with diabetes and osteoporosis.
FAQs
Weight transfer through the proximal tibia depends on coordinated contact between the tibial plateau and femoral condyles. The medial and lateral condyles receive forces from the femur, while the intercondylar region contributes to stability during knee movement. Damage or altered structure in these areas can disrupt load transmission and impair normal mobility and knee function.
The medial and lateral condyles form the principal articular regions connecting the tibia with the femur. Their condition affects how forces pass across the knee and how the joint supports movement. Clinical evaluation therefore considers these regions when investigating fractures, degenerative changes, or other structural problems that may interfere with weight bearing and function.
The tibial plateau provides an important support surface within the knee and participates in transmitting weight from the femur into the leg. Injuries involving this region, particularly tibial plateau fractures, may alter joint support and movement. Recognizing the affected area helps clinicians assess the injury and plan appropriate treatment and rehabilitation.
The intercondylar region contributes to knee stability and movement, so damage there may influence how the joint maintains alignment during activity. Its involvement is clinically relevant when evaluating ligament-related damage and other injuries around the knee. Assessment of this region helps connect structural findings with possible limitations in mobility and knee function.
Evaluation combines physical examination with imaging to identify abnormalities in the proximal tibia and surrounding knee structures. This approach can help detect tibial plateau fractures, growth-plate injuries, degenerative changes, and ligament-related damage. The findings support diagnosis and provide a basis for selecting treatment, fixation, or rehabilitation strategies suited to the condition.
Imaging becomes particularly relevant when clinicians need to investigate suspected fractures, growth-plate injuries, degenerative changes, or ligament-related damage involving the knee region. It complements physical examination by helping identify structural abnormalities that may not be fully characterized clinically. The resulting information can guide treatment planning and decisions about fracture fixation or rehabilitation.