Lesion Progression
Lesion Progression - Related Videos
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
06:43
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Cited by 51 •
2013
We describe procedures to quantify and characterize atherosclerotic lesions in mouse models using precision sectioning of the aortic sinus and ascending aorta combined with histochemical and immunohistochemical analysis.
09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Cited by 13 •
2017
We developed a method to successfully remove, process, section, and stain, for histopathological evaluation, mammary tissue that had originally been fixed on slides as whole mounts. This method may promote the collection and evaluation of mammary gland whole mounts in reproductive and developmental test guideline studies.
05:51
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Cited by 13 •
2014
Atherosclerosis is a chronic inflammatory process. This manuscript illustrates an easy to use ex vivo model to investigate fresh carotid or coronary artery plaques. The ex vivo model allows for the investigation of potential substances on the inflammatory milieu in human atherosclerotic lesions and results can be analyzed by various methods.
09:26
Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies
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Cited by 6 •
2009
Practicing of fine needle aspiration biopsies (FNAB) by trainees is relatively challenging, due to the lack of an easily available, appropriate lesion. Preparation of an AV phantom lesion for practicing the FNAB procedure and mastering proficiency is relatively easy.
FAQs
Whether a lesion resolves or worsens depends on the balance between microbial control and collateral inflammation. The invading organism or antigen interacts with resident cells and recruited leukocytes, while cytokines and vascular changes shape the local response. When tissue injury and inflammatory activity outweigh effective control and repair, progression can include persistence or worsening rather than recovery.
Cellular composition, necrosis, and fibrosis provide complementary information about tissue change over time. Cellular composition reflects the local participation of resident cells and recruited leukocytes, while necrosis and fibrosis identify distinct structural outcomes. Examining these features with lesion size helps researchers evaluate disease mechanisms, tissue injury, and the balance between inflammation and repair.
In infectious disease, an invading organism is a central initiating factor, whereas immune-mediated disease may involve an antigen as the relevant trigger. Despite that difference, both settings can include resident cells, recruited leukocytes, cytokines, vascular changes, and repair responses. Comparing these contributors helps researchers determine how distinct initiating factors produce different patterns of tissue injury.
Researchers can follow progression by comparing lesion size, cellular composition, necrosis, and fibrosis at defined stages or time points. These measurements connect structural change with the underlying host response rather than relying on lesion size alone. The resulting trajectory can indicate healing, persistence, or worsening and provide a framework for disease staging.
Changes in lesion characteristics can help evaluate treatment effects. Researchers may examine whether progression moves toward improved microbial control and tissue repair or continues toward persistence and damage after an intervention. Assessing lesion size, cellular composition, necrosis, and fibrosis links treatment evaluation to both disease mechanisms and measurable tissue outcomes.
Lesion progression provides a tissue-level outcome for studying host resistance and microbial control in vaccine and antimicrobial research. It also supports evaluation of immunomodulatory therapies, where researchers must consider whether changing inflammation alters tissue injury as well as disease control. These applications connect intervention effects with disease staging, repair responses, and collateral inflammatory damage.